Protective Effect of Cordycepin on Experimental Testicular Ischemia/Reperfusion Injury in Rats

Okur, Mehmet Hanifi; Arslan, Serkan; Aydogdu, Bahattin; Zeytun, Hikmet; Basuguy, Erol; Arslan, Mehmet; İbiloğlu, İbrahim; Kaplan, İbrahim

doi:10.1080/08941939.2016.1246629

Cited by 25 publications

(19 citation statements)

References 28 publications

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“…Importantly, cordycepin has been shown to attenuate age-related oxidative stress and enhances antioxidant capacity in rats 46 . It has also been shown to prevent rat hearts from ischemia/reperfusion injury partially by activating antioxidant defense 47,48 . Cordycepin represents a promising agent for future potential clinical application.…”

Section: Discussionmentioning

confidence: 99%

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

et al. 2019

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The pathological mechanisms of radiation ulcer remain unsolved and there is currently no effective medicine. Here, we demonstrate that persistent DNA damage foci and cell senescence are involved in radiation ulcer development. Further more, we identify cordycepin, a natural nucleoside analogue, as a potent drug to block radiation ulcer (skin, intestine, tongue) in rats/mice by preventing cell senescence through the increase of NRF2 nuclear expression (the assay used is mainly on skin). Finally, cordycepin is also revealed to activate AMPK by binding with the α1 and γ1 subunit near the autoinhibitory domain of AMPK, then promotes p62-dependent autophagic degradation of Keap1, to induce NRF2 dissociate from Keap1 and translocate to the nucleus. Taken together, our findings identify cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents, and activation of AMPK or NRF2 may thus represent therapeutic targets for preventing cell senescence and radiation ulcer.

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Section: Discussionmentioning

confidence: 99%

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

et al. 2019

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“…Among these natural active compounds, cordycepin has been proved to be an important immunomodulatory active compound which affects the actions of immune cells and cytokine network, it could protect against ischemia–reperfusion‐induced testicular injury. Cordycepin inhibits melanoma cell growth in mice with no adverse effects (Okur et al, ; Wang et al, ; Yoshikawa et al, ; Zhou et al, ). CMP could effectively improve the immune function through protection against oxidative stress, and even could have stronger abilities of hypoglycemic effects than Cordyceps sinensis polysaccharide (Liu et al, ; Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of superfine grinding on the properties and qualities of Cordyceps militaris and its spent substrate

Shi

Zhang

Bhandari

et al. 2019

J Food Process Preserv

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The main purpose of this study is to study the effect of superfine grinding (SG) technology on the physicochemical properties of Cordyceps militaris (CM) and its spent substrate (SS). The results showed that the particle size of the sample powder decreased significantly under the SG treatment and reached below 15 μm finally. With the decrease in particle size, the surface tension of materials decreased and water‐holding capacity (WHC) of aqueous solution of CM and its SS powder decreased by 58.72% and 48.36%, while the water soluble index (WSI) increased to 0.73 and 0.44 g/g, respectively, also the hygroscopic property, L* value and DPPH radical scavenging capacity increased significantly. In addition, the cordycepin yield of two materials increased by 9.49% and 14.61% for 4 hr SG treatment, respectively. The results showed that the SG technology could effectively improve the physicochemical properties of CM powder and the extraction of its effective components, in addition, a new idea was opened up for the effective utilization of waste materials such as edible and medicinal fungi culture medium. Practical applicationsThis study investigated the effect of superfine grinding treatments on the physicochemical properties of the powder of Cordyceps militaris (CM) and its spent substrate (SS). The results shows the advances of superfine grinding on the particle size, surface tension, water hydration capacity, color, antioxidant capacity, and the yield of active component. And it could realize the maximum utilization of resources like medical plants and the reutilization of the waste during herb culturing, when treatments like superfine grinding was applied.

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“…Increasing evidences suggest that mTOR is deeply involved in IR injury of various organs and tissues, including heart, brain, kindey, liver and other organ or tissues [12, 85, 114, 146, 147]. The modulation of mTOR expression appears to be a promising strategy for attenuating IR injury.…”

Section: Discussionmentioning

confidence: 99%

“…Simvastatin reduces IR injury through the inhibition of mTOR and activation of mitophagy [72]. Testicular IR injury is usually induced by torsion/detorsion, and inhibition mTOR reduces the apoptosis on IR damage in rat testis [15, 146, 147]. Additionally, attenuating Akt/mTOR/ p70S6K pathway reduces kidney inflammation and apoptosis after hepatic IR [18].…”

Section: The Negative Aspect Of Mtor In Ir Injurymentioning

confidence: 99%

Snapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury

Liu¹,

Xu²,

Zhang³

et al. 2019

Aging and disease

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Aging may aggravate the damage and dysfunction of different components of multiorgan and thus increasing multiorgan ischemia/reperfusion (IR) injury. IR injury occurs in many organs and tissues, which is a major cause of morbidity and mortality worldwide. The kinase mammalian target of rapamycin (mTOR), an atypical serine/threonine protein kinase, involves in the pathophysiological process of IR injury. In this review, we first briefly introduce the molecular features of mTOR, the association between mTOR and aging, and especially its role on autophagy. Special focus is placed on the roles of mTOR during ischemic and IR injury. We then clarify the association between mTOR and conditioning phenomena. Following this background, we expand our discussion to potential future directions of research in this area. Collectively, information reviewed herein will serve as a comprehensive reference for the actions of mTOR in IR injury and may be significant for the design of future research and increase the potential of mTOR as a therapeutic target.

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Protective Effect of Cordycepin on Experimental Testicular Ischemia/Reperfusion Injury in Rats

Abstract: Histological and biochemical findings revealed that cordycepin protected against IR-induced testicular injury.

Cited by 25 publications

References 28 publications

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

Effects of superfine grinding on the properties and qualities of Cordyceps militaris and its spent substrate

Snapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury

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