Protective Effect of Chronic Garlic Intake on Elastic Properties of Aorta in the Elderly

Breithaupt-Grögler, Kerstin; Ling, Michael C; Boudoulas, Harisios; Belz, G. G.

doi:10.1161/01.cir.96.8.2649

Cited by 126 publications

(56 citation statements)

References 36 publications

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“…Previous studies reported that elastic properties of the aorta decrease with age. 23,24 Although the exact mechanisms of progression in patients with IMH remains unclear, decreased distensibility of descending aorta may play an important role in the disease process in patients with IMH. 12,25 One limitation of this study was relatively small sample number for multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Prognosis of Patients With Type B Aortic Intramural Hematoma

et al. 2003

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Background-The long-term clinical course of patients with type B aortic intramural hematoma (IMH) and predictors for progression remains unknown. The difference of aortic pathology may have a different impact on clinical course compared with classic aortic dissection (AD). The purpose of this study was to investigate long-term clinical course and predictors of progression in patients with type B IMH. Methods and Results-Clinical data were compared retrospectively between 53 patients with acute type B IMH (IMH group) and 57 patients with acute type B AD (AD group). All patients were treated initially with medical therapy. Two patients in IMH group and 14 patients in AD group underwent surgical repair because of aortic enlargement. The in-hospital mortality rate in IMH group was significantly lower than that in AD group (0% and 14%, Pϭ0.006). Mean follow-up periods were 53Ϯ43 months, which revealed 3 and 5 late deaths, respectively. Eleven patients with IMH showed progression (development of aortic dissection or aortic enlargement) in follow-up imaging study. The actuarial survival rates in IMH group were 100%, 97%, and 97% at 1, 2, and 5 years, which were significantly higher than those in AD group (83%, 79%, and 79%) (Pϭ0.009). Multivariate analysis identified age Ͼ70 years and new appearance of an ulcerlike projection as the strongest predictors of progression in patients with IMH. Conclusions-Patients

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Section: Discussionmentioning

confidence: 99%

Long-Term Prognosis of Patients With Type B Aortic Intramural Hematoma

et al. 2003

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Section: Anthropometric and Haemodynamic Parametersmentioning

confidence: 99%

“…34 PWV (m Â s À1 ) was calculated as the ratio between the distance travelled by the pulse wave and pulse transmission time. 34 Augmentation index was calculated from pulse waves of the common carotid artery that were recorded by applanation tonometry. 1,10 Data were collected directly into a portable computer; integral software was used to generate an averaged peripheral waveform (SphygmoCor, PWV Medical, Sydney, Australia).…”

Section: Anthropometric and Haemodynamic Parametersmentioning

confidence: 99%

Diastolic blood pressure is an important determinant of augmentation index and pulse wave velocity in young, healthy males

Nürnberger¹,

Dammer²,

Saez

et al. 2003

J Hum Hypertens

118

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Pulse wave velocity (PWV) and augmentation index are widely used measures of arterial stiffness. The purpose of this study was to evaluate the role of blood pressure as a determinant of both indices independent of potentially confounding factors including gender, age and cardiovascular disorders. A total of 77 young, healthy subjects were investigated under resting conditions. Augmentation index was derived by pulse wave analysis using carotid applanation tonometry. PWV was determined from pressure tracing over the carotid and femoral artery. The relations between stiffness markers and haemodynamic parameters were analysed by simple (r) and multiple (b) regression analysis. Using simple regression analysis, augmentation index was correlated to age (r ¼ 0.292, P ¼ 0.0105), diastolic blood pressure (DBP, r ¼ 0.483, Po0.0001), mean arterial blood pressure (MAP, r ¼ 0.381, P ¼ 0.0007), pulse pressure (r ¼ À0.414, P ¼ 0.0002) and total peripheral resistance (r ¼ 0.266, P ¼ 0.0204). After multiple regression analysis, augmentation index remained significantly correlated only to DBP (b ¼ 0.347, P ¼ 0.0051). Using simple regression analysis, PWV was correlated to age (r ¼ 0.304, P ¼ 0.0067), systolic blood pressure (r ¼ 0.280, P ¼ 0.0129). DBP (r ¼ 0.455, Po0.0001), MAP (r ¼ 0.446, Po0.0001) and heart rate (r ¼ 0.348, P ¼ 0.0018). After multiple regression analysis, PWV remained correlated only to age (b ¼ 0.218, P ¼ 0.0422) and DBP (b ¼ 0.4105, P ¼ 0.0316). In summary, DBP is an important determinant of augmentation index and PWV in young, healthy males. Further studies are needed to characterize the impact of blood pressure on arterial stiffness in other populations including females and older subjects.

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“…PWV (m/s) was calculated as the ratio between the distance travelled by the pulse wave and pulse transmission time. 19 Pulse wave analysis was performed in 72 subjects (CC, n ¼ 30; TC&TT, n ¼ 42), as previously described by our laboratory. 16,20 Central haemodynamics were calculated from radial pulse waves that were recorded by applanation tonometry.…”

Section: Anthropometric and Haemodynamic Parametersmentioning

confidence: 99%

The T-allele of the C825T polymorphism is associated with higher arterial stiffness in young healthy males

et al. 2004

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Protective Effect of Chronic Garlic Intake on Elastic Properties of Aorta in the Elderly

Abstract: Chronic garlic powder intake attenuated age-related increases in aortic stiffness. These data strongly support the hypothesis that garlic intake had a protective effect on the elastic properties of the aorta related to aging in humans.

Cited by 126 publications

References 36 publications

Long-Term Prognosis of Patients With Type B Aortic Intramural Hematoma

Long-Term Prognosis of Patients With Type B Aortic Intramural Hematoma

Diastolic blood pressure is an important determinant of augmentation index and pulse wave velocity in young, healthy males

The T-allele of the C825T polymorphism is associated with higher arterial stiffness in young healthy males

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