2012
DOI: 10.1007/s11418-012-0663-x
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Protective effect of Chresta martii extract against indomethacin-induced gastric lesions in mice

Abstract: Chresta martii (Asteraceae) is a plant found in the Xingó region (semi-arid area) in Northeastearn Brazil, and is recognized by the local population as a traditional herb used to treat gastric diseases. This is the first report of the chemical composition, acute toxicity, and gastroprotective effect in mice of the hydroalcoholic extract (HAE) from the aerial parts (leaves and flowers) of Chresta martii. Animals received HAE doses from 10 to 2000 mg/kg, i.p. or 50 to 3000 mg/kg, p.o.) and were observed over 48 … Show more

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Cited by 8 publications
(10 citation statements)
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“…A previous study using a hydroalcoholic extract of aerial parts of C. martii (100 or 400 mg/kg; p.o.) showed significant gastroprotective activity in an ulcer model induced by indomethacin, with inhibition indices of 54.66 and 81.30, respectively [ 14 ]. Our results demonstrate superior gastroprotective activity with EACm (100 or 200 mg/kg; p.o.)…”
Section: Resultsmentioning
confidence: 99%
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“…A previous study using a hydroalcoholic extract of aerial parts of C. martii (100 or 400 mg/kg; p.o.) showed significant gastroprotective activity in an ulcer model induced by indomethacin, with inhibition indices of 54.66 and 81.30, respectively [ 14 ]. Our results demonstrate superior gastroprotective activity with EACm (100 or 200 mg/kg; p.o.)…”
Section: Resultsmentioning
confidence: 99%
“…(79.89% and 80.83%, resp.) taking into consideration the fact that the second dose of EACm was 50% less than the highest dose used by Silva et al [ 14 ]. The best performance observed in our work was due to the extractive process and choice of solvent.…”
Section: Resultsmentioning
confidence: 99%
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