Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats

Yeşil, Süleyman; Ozdemir, Cagri; Arslan, Mustafa; Gündoğdu, Ayşe; Kavutçu, Mustafa; Atan, Ali

doi:10.3892/etm.2022.11700

Cited by 10 publications

(11 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apoptosis happens when this apoptosome activates the initiator caspase-9 and the effector caspase-3 [32,33]. Furthermore, it has been demonstrated that lupeol downregulates caspase-3 in the experimental cerebral IR model through the PI3K/Akt signaling pathway [17,30].…”

Section: Discussionmentioning

confidence: 99%

Effects of Lupeol On Experimental Testicular Ischemia/Reperfusion Damage in Rats

Azzam,

Karabulut,

Kaya

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective Infertility and organ loss are possible outcomes of testicular torsion, a urological emergency. We sought to demonstrate the impact of lupeol on testicular ischemia reperfusion damage in this investigation.Methods 30 adult male Spraque Dawley rats were randomized and divided as Control(C), Lupeol(L), Ischemia(I), Treatment 1(T1) and Treatment 2(T2) groups. In the study groups, detorsion was applied to the left testicles by creating 720 degree testicular torsion for 2 hours. While 100 mg/kg Lupeol was injected intraperitoneally in the T1 and T2 groups 30 min. before and immediately after testicular detorsion. At the sixth hour, samples of blood and testicular tissue were obtained from every rat. Measurements were taken of serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) tissue glutathione (GSH), malondialdehyde (MDA), and caspase 3. Histopathological analysis was used to evaluate the Johnsen Tubular Biopsy Score (JTBS).Results It was observed that Caspase 3, MDA, IL-6 and TNF-ɑ values, which increased in Group I compared to the Group C, decreased more significantly in both treatment groups and especially in the GroupT1 group (p = 0.001, only p = 0.768 for TNF-ɑ). GSH levels was decreased in Group I, increased more significantly in both treatment groups and especially in the GroupT1 group. JTBS improvement was observed in both treatment groups (p = 0.001).Conclusion In this study, where Lupeol was used for the first time in an experimental testicular torsion model, its antioxidant, anti-inflammatory and anti-apoptotic effects, as well as its histopathological damage-reducing and protective effects, were demonstrated.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Lupeol On Experimental Testicular Ischemia/Reperfusion Damage in Rats

Azzam,

Karabulut,

Kaya

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Pre-adolescent patients sometime present late due to shyness regarding conveying their condition to parents. The protective effect of cerium oxide (CeO 2 ) on testicular function is being explored in experimental studies [ 21 ]. CeO 2 reduces oxidative stress, cell trauma, and death in testis tissue in experimental rats.…”

Section: Discussionmentioning

confidence: 99%

“…CeO 2 reduces oxidative stress, cell trauma, and death in testis tissue in experimental rats. In this study rats in the CeO2 group demonstrated significantly milder tissue lesions compared with those in the control group [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Acute Scrotum in Children: A Retrospective Study of Cases With Review of Literature

Chanchlani¹,

Acharya²

2023

Cureus

View full text Add to dashboard Cite

Background: Testicular pain or swelling, often referred to as acute scrotum, can have a number of causes and presentations. Testicular torsion is an emergency condition requiring early diagnosis and surgery to salvage the involved testis in order to preserve testicular fertility. The study is aimed to know the incidence, aetiology, and management of acute scrotal conditions with a particular focus on testicular torsion. Epididymorchitis, trauma, and scrotal cellulitis are other causes of acute scrotum which are managed conservatively after proper investigations.Material and methods: The authors retrospectively reviewed 10-year epidemiological data of all children age under 14 years admitted to the tertiary care hospital with the diagnosis of acute scrotum. Data were collected about the clinical history, physical examination, biochemical investigations, Doppler ultrasound, and management done.Results: 133 children aged between 0 days and 14 years (mean age, 7.5 years) were found to have acute scrotum out of which 67 (50.37%) patients had epididymitis, 54 (40.60%) patients presented with Torsion testis, three (2.25%) had torsion of testicular appendages, eight (6.01%) had scrotal cellulitis and one (0.75%) presented with a strangulated hernia. Due to late presentation, testis could be salvaged in only eight of the 54 patients with torsion testis. The testicular loss was seen more in bigger children and those with signs of infection in blood reports and colour Doppler showing no blood flow in the testis. Conclusion:The study results indicate that non-recognition of the severity of paediatric acute scrotum results in late presentation leading to testicular loss. Timely diagnosis will require sensitization of the parents, primary care providers, and paediatricians for this grave condition which leads to permanent testicular loss.

show abstract

“…The animals were fed a standard pellet diet and allowed to drink water ad libitum. The dose of ketamine and Rompun administered to the rats was in accordance with the study by Yesil et al (15).…”

Section: Methodsmentioning

confidence: 96%

Effect of fullerenol C60 on lung and renal tissue in lower extremity ischemia‑reperfusion injury in sevoflurane‑treated rats

Arpaci,

Köksal,

Yiğman

et al. 2024

Mol Med Rep

Self Cite

View full text Add to dashboard Cite

The aim of the present study was to examine the effect of fullerenol C60 on lung and kidney tissue in sevoflurane-treated rats with lower extremity ischemia-reperfusion (IR) injury. A total of 30 Wistar albino rats weighing 225-275 g were used and were equally divided into five groups (n=6/group): i) Sham; ii) IR; iii) IR-fullerenol C60 (IR-FUL); iv) IR-sevoflurane; and v) IR-fullerenol C60-sevoflurane (IR-FUL-SEVO). Fullerenol C60 was administered intraperitoneally prior to lower extremity IR induction and sevoflurane was administered during the IR injury. Subsequently, lung and kidney histopathological examinations, and serum biochemical analyses were performed. Lung tissue showed markedly increased congestion and neutrophil infiltration in the IR group compared with in the sham group, and notable decreases in congestion and neutrophil infiltration were observed in the treatment groups compared with in the IR group. In the histopathological evaluation of the kidney samples, vacuolization, loss of brush border in tubular epithelial cells, tubular epithelial loss and varying degrees of tubular damage were observed in all groups that underwent IR. There was a significant increase in the mean renal tubule injury score in all IR groups compared with that in the sham group. In addition, the mean kidney injury score was significantly lower in the IR-FUL and IR-FUL-SEVO groups than that in the IR group.It was observed that the expression levels of tumor necrosis factor-α, interleukin 1β and intercellular adhesion molecule 1 in the lung and kidney tissues were increased following IR, and were decreased in the groups treated with fullerenol C60 and sevoflurane. Notably, it was determined that the reduction in cytokine expression was greatest in the IR-FUL group. When the oxidant status parameters in the lungs and kidneys were examined, thiobarbituric acid reactive substances levels, and catalase and glutathione S-transferase enzyme activities were significantly different in the groups receiving sevoflurane or fullerenol C60 treatment compared with those in the IR group. The present study demonstrated the protective effects of fullerenol C60 on the lung and kidney tissues of rats under sevoflurane anesthesia after establishment of lower extremity IR. The results of the present study showed that fullerenol C60 can reduce oxidative and histopathological damage in the lungs and kidneys following IR of the lower extremities.

show abstract

Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats

Cited by 10 publications

References 88 publications

Effects of Lupeol On Experimental Testicular Ischemia/Reperfusion Damage in Rats

Effects of Lupeol On Experimental Testicular Ischemia/Reperfusion Damage in Rats

Acute Scrotum in Children: A Retrospective Study of Cases With Review of Literature

Effect of fullerenol C60 on lung and renal tissue in lower extremity ischemia‑reperfusion injury in sevoflurane‑treated rats

Contact Info

Product

Resources

About