Protective effect of CeO&lt;sub&gt;2&lt;/sub&gt; nanoparticles on photo-induced oxidative damage of DNA

Fujita, Naoko; Kamada, Kei

doi:10.2109/jcersj2.122.141

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…For instance, zholobak et al [15] reported that CNPs prevented the decrease in cell viability of mouse fibroblasts (L929) and fibroblast-like cells of African Green monkey (VERO) exposed to UV. Fujita and Kamada [16] demonstrated that CNPs decreased oxidized DNA under UV light. Zholobak et al [17] reported that panthenol-stabilized CNPs protect human epidermoid cancer cells (Hep-2) and the diploid epithelial swine testicular cell line (ST-cells) from ROS and UV irradiation.…”

Section: Introductionmentioning

confidence: 99%

Cerium Oxide Nanoparticles Conjugated with Tannic Acid Prevent UVB-Induced Oxidative Stress in Fibroblasts: Evidence of a Promising Anti-Photodamage Agent

et al. 2023

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Exposure to ultraviolet radiation induces photodamage towards cellular macromolecules that can progress to photoaging and photocarcinogenesis. The topical administration of compounds that maintain the redox balance in cells presents an alternative approach to combat skin oxidative damage. Cerium oxide nanoparticles (CNPs) can act as antioxidants due to their enzyme-like activity. In addition, a recent study from our group has demonstrated the photoprotective potential of tannic acid (TA). Therefore, this work aimed to synthesize CNPs associated with TA (CNP-TA) and investigate its photoprotective activity in L929 fibroblasts exposed to UVB radiation. CNP conjugation with TA was confirmed by UV–Vis spectra and X-ray photoelectron spectroscopy. Bare CNPs and CNP-TA exhibited particle sizes of ~5 and ~10 nm, superoxide dismutase activity of 3724 and 2021 unit/mg, and a zeta potential of 23 and −19 mV, respectively. CNP-TA showed lower cytotoxicity than free TA and the capacity to reduce the oxidative stress caused by UVB; supported by the scavenging of reactive oxygen species, the prevention of endogenous antioxidant system depletion, and the reduction in oxidative damage in lipids and DNA. Additionally, CNP-TA improved cell proliferation and decreased TGF-β, metalloproteinase-1, and cyclooxygenase-2. Based on these results, CNP-TA shows therapeutic potential for protection against photodamage, decreasing molecular markers of photoaging and UVB-induced inflammation.

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Section: Introductionmentioning

confidence: 99%

Cerium Oxide Nanoparticles Conjugated with Tannic Acid Prevent UVB-Induced Oxidative Stress in Fibroblasts: Evidence of a Promising Anti-Photodamage Agent

et al. 2023

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“…NCD and water-soluble unmodified C60 fullerene exhibit radioprotective properties and can strongly reduce the harmful effects of ionizing radiation 16,17 . Cerium dioxide nanoparticles also have a photoprotective effect to the cells against ultraviolet light 18,19 . There are some reported data that nanoparticles of unmodified C60 fullerene protect skeletal muscles from ischemic lesions 20,21 , have a stabilizing effect on ISSN: 2250-1177 [2] CODEN (USA): JDDTAO enzymes, protecting them from thermal and oxidative inactivation 22 .…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles of Cerium Dioxide and Pristine (Unmodified) Fullerene C60 Protect Living Cells against Adverse Environmental Exposure: Does it Work?

Falko

Chizhevskiy²,

Klochkov³

et al. 2022

J. Drug Delivery Ther.

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We believe that unmodified hydrated C60 fullerene (C60FWS) and nanocrystalline cerium dioxide (NCD) are promising for biological research. It is knowns that these nanoparticles protect living cells from damaging environmental factors such as radioactive and ultraviolet radiation, temperature, hypoxia, toxic substances, etc. However, little attention has been paid in scientific reports to the use and study of these nanoparticles as possible adaptogens. In our studies, we tried to protect the culture of cyanobacteria Spirulina platensis with C60 and NCD from adverse conditions. The choice of Spirulina platensis is due to its sensitivity to adverse environmental factors. The results obtained show that the absence of toxic effects of C60 and NCD of selected concentrations on the Spirulina platensis culture has been found. Nanoparticles C60 and NCD maintained the culture of Spirulina platensis for at least 4 weeks in the absence of nutrients, light, low pH storage conditions and low temperature. Cyanobacteria stored for 1–4 weeks in distilled water with nanoparticles showed increased proliferative activity compared to samples stored at the same time in the standard Zarrouk’s nutrient medium. Keywords: fullerene C60, nanocrystalline cerium dioxide, Spirulina platensis, adaptogens.

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Enzyme-Mimetic Activity of Ce-Intercalated Titanate Nanosheets

Kamada

Soh

2015

J. Phys. Chem. B

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Colloidal solutions of Ce-doped titanate nanosheets (Ce-TNS) with tiny dimensions (<10 nm) were fabricated through a hydrolysis reaction of titanium tetraisopropoxide and Ce(NO3)3, and their annihilation activity for reactive oxygen species (ROS) was investigated. The obtained Ce-TNS had an akin crystal structure to layered tetratitanate (Ti4O9(2-)) and Ce ions occupied interlayer space between the host layers with a negative charge. The Ce-TNS possessed a superoxide dismutase (SOD) mimetic activity for disproportionation of superoxide anion radicals (O2(-)) as target ROS. It was explained that the annihilation of O2(-) caused a valence fluctuation of Ce ions existing in the interlayer. Moreover, the activity of Ce-TNS exceeded that of CeO2 nanoparticles recently attracting much attention as an inorganic SOD mimic. The superior performance was explained mainly by a high dispersion stability of the Ce-TNS bringing about a huge reaction area. Moreover, the Ce-TNS protected DNA molecules from ultraviolet light induced oxidative damage, demonstrating effectiveness as one of the new inorganic protecting agents for biomolecules and tissues.

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Protective effect of CeO<sub>2</sub> nanoparticles on photo-induced oxidative damage of DNA

Cited by 3 publications

References 14 publications

Cerium Oxide Nanoparticles Conjugated with Tannic Acid Prevent UVB-Induced Oxidative Stress in Fibroblasts: Evidence of a Promising Anti-Photodamage Agent

Cerium Oxide Nanoparticles Conjugated with Tannic Acid Prevent UVB-Induced Oxidative Stress in Fibroblasts: Evidence of a Promising Anti-Photodamage Agent

Nanoparticles of Cerium Dioxide and Pristine (Unmodified) Fullerene C60 Protect Living Cells against Adverse Environmental Exposure: Does it Work?

Enzyme-Mimetic Activity of Ce-Intercalated Titanate Nanosheets

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