Protective effect of carvacrol on acetic acid-induced colitis

Souza, Marília Trindade de Santana; Teixeira, Daniela Cabral Pizzi; Oliveira, Janaíne P.; Oliveira, Alan Santos; Quintans‐Júnior, Lucindo José; Corrêa, Cristiane Bani; Camargo, Enilton A.

doi:10.1016/j.biopha.2017.10.017

Cited by 26 publications

(10 citation statements)

References 51 publications

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“…These findings indicate that the administration of carvacrol acted by reducing inflammatory, nociceptive, and oxidative damage in the model studied [55].…”

Section: Carvacrolsupporting

confidence: 51%

“…Pretreatment with all doses of carvacrol reduced abdominal hyperalgesia, colon myeloperoxidase (MPO) activity, lipid peroxidation, and levels of TNF-α and IL-1β. The authors observed a reduction in macroscopic and microscopic damage (p < 0.05) at doses of 50 or 100 mg/kg and an increase in sulfhydryl groups (100 mg/kg) [55]. Studies demonstrated a significant infiltration of neutrophils by humans with UC, with a consequent increase in MPO activity [57,58].…”

Section: Carvacrolmentioning

confidence: 95%

“…Pretreatment with carvacrol in doses (25, 50 or 100 mg/kg, p.o.) was performed every 12 h for three days before induction [55].…”

Section: Carvacrolmentioning

confidence: 99%

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Intestinal Anti-Inflammatory Activity of Terpenes in Experimental Models (2010–2020): A Review

et al. 2020

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Inflammatory bowel diseases (IBDs) refer to a group of disorders characterized by inflammation in the mucosa of the gastrointestinal tract, which mainly comprises Crohn’s disease (CD) and ulcerative colitis (UC). IBDs are characterized by inflammation of the intestinal mucosa, are highly debilitating, and are without a definitive cure. Their pathogenesis has not yet been fully elucidated; however, it is assumed that genetic, immunological, and environmental factors are involved. People affected by IBDs have relapses, and therapeutic regimens are not always able to keep symptoms in remission over the long term. Natural products emerge as an alternative for the development of new drugs; bioactive compounds are promising in the treatment of several disorders, among them those that affect the gastrointestinal tract, due to their wide structural diversity and biological activities. This review compiles 12 terpenes with intestinal anti-inflammatory activity evaluated in animal models and in vitro studies. The therapeutic approach to IBDs using terpenes acts basically to prevent oxidative stress, combat dysbiosis, restore intestinal permeability, and improve the inflammation process in different signaling pathways.

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“…These findings indicate that the administration of carvacrol acted by reducing inflammatory, nociceptive, and oxidative damage in the model studied [55].…”

Section: Carvacrolsupporting

confidence: 51%

Section: Carvacrolmentioning

confidence: 95%

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Intestinal Anti-Inflammatory Activity of Terpenes in Experimental Models (2010–2020): A Review

et al. 2020

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“…They were lost or distorted in most areas. Similar findings were recorded in acetic acid-induced colitis of previous studies (Sen et al 2017;De Santana Souza et al 2017;Abdel Mohsen and Ahmed 2019;Malago and Sangu 2015). Also, Sharma et al (2021) reported the presence of intermittent areas of epithelial losses after acute exposure of mice (1 week) to nicotine-containing e-cig aerosols, while the inflammatory infiltrates within the colonic submucosa were enormous in chronic exposure (3 months).…”

Section: Discussionsupporting

confidence: 86%

Impact of e-cigarettes on colonic mucosa and the role of recovery: involvement of oxidative and inflammatory pathway

Mohammed

El-Din

Farag

2021

Environ Sci Pollut Res

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Electronic cigarettes (e-cigarettes) (EC) are often advertised as a safer alternative to conventional cigarettes. Its widespread use has led to increased interest in its adverse health effects, thanks to few restrictions and a lack of regulatory guidelines. The study aimed to evaluate the influence of exposure to e-cigarette aerosol inhalation in rat colon model and conduct a follow-up after cessation of exposure. The experiment included 30 male adult Albino rats. The animals were divided into three groups: group I (control), non-exposed animals; group II (exposed), was exposed to electronic cigarette liquid vapor for four consecutive weeks; and group III (recovery), was followed up for another 4 weeks after exposure to an e-cigarette as exposed group and for the same duration. In the exposed group, malondialdehyde (MDA) and total nitric oxide (NO) increased significantly in colonic tissue, while superoxide dismutase (SOD) decreased. On histological examination, colonic mucosa showed distortion and loss of its epithelial lining with heavy inflammatory cell infiltration. Also, there was a significant decrease in periodic acid-Schiff-positive goblet cells and area percent of proliferating cell nuclear antigen expression. Tumor necrosis factor-alpha (TNFα) expression significantly increased in colonic mucosa. After 4 weeks of EC cessation, the colonic mucosal histological structure showed recovery with downregulated TNFα immunoexpression and restored oxidant/antioxidant balance. In conclusion, the usage of electronic cigarettes resulted in marked pathological alterations in the colonic mucosa, which could be attributed to oxidative and inflammatory stresses. In contrast, the cessation of exposure led to recovery.

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“…The classical method was used here to induce colitis [15]. Mice were anesthetized by ether after fasting for 24 h. Next, a flexible catheter (3.5 F) was inserted into the colon with a depth of approximately 3 cm away from the anus.…”

Section: Methodsmentioning

confidence: 99%

Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response

Wang

Shi

et al. 2019

Oxidative Medicine and Cellular Longevity

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Ulcerative colitis (UC) is an inflammation-related disease involved in uncontrolled inflammation and oxidative stress and is characterized by high recurrence and relapse risk. As a rising star in gas medicine, methane owns the properties of anti-inflammation, antioxidation, and antiapoptosis. Based on the possible mechanism, we aimed to investigate the effect of methane on UC. Methane-rich saline (MRS) was introduced here, and UC was induced by acetic acid. All the C57BL/6 mice were allocated into groups as follows: control group, colitis model group, colitis treated with salazosulfapyridine (SASP) group, and colitis treated with MRS (1 or 10 ml/kg) groups. Tissue damage, the degree of inflammation, oxidative stress, and apoptosis were evaluated in the study, as well as the TLR4/NF-κB/MAPK and IL-10/JAK1/STAT3 signaling pathways for further exploration of the potential mechanism. The results showed that MRS (1) alleviated tissue damage caused by acetic acid, (2) controlled acetic acid-induced inflammation, (3) inhibited acetic acid-caused oxidative stress, (4) reduced colonic cell apoptosis due to acetic acid, (5) suppressed the TLR-4/NF-κB/MAPK signaling pathway, and (6) activated IL-10/JAK1/STAT3 anti-inflammatory response to improve the injury induced by acetic acid. We conclude that MRS has a protective effect on acetic acid-induced ulcerative colitis in mice via blocking the TLR4/NF-κB/MAPK signaling pathway and promoting the IL-10/JAK1/STAT3-mediated anti-inflammatory response.

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Protective effect of carvacrol on acetic acid-induced colitis

Cited by 26 publications

References 51 publications

Intestinal Anti-Inflammatory Activity of Terpenes in Experimental Models (2010–2020): A Review

Intestinal Anti-Inflammatory Activity of Terpenes in Experimental Models (2010–2020): A Review

Impact of e-cigarettes on colonic mucosa and the role of recovery: involvement of oxidative and inflammatory pathway

Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response

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