Protective effect of Capparis spinosa on chondrocytes

Panico, Annamaria; Cardile, Venera; Garufi, F.; Puglia, Carmelo; Bonina, Francesco; Ronsisvalle, Giuseppe

doi:10.1016/j.lfs.2004.12.051

Cited by 110 publications

(71 citation statements)

References 25 publications

(22 reference statements)

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“…CS is an antioxidant source against oxidative stress due to its flavonoid content. Some flavonoids (kaempferol and quercetin derivatives) and hydrocinnamic acids in extracts exerting their protective effects are may be possible mechanism (Panico et al 2005). In vitro antioxidant and in vivo photoprotective effects of a lyophilized CS buds (LECS) were also investigated and it was found that LECS showed a significant in vivo protection against UVB lightinduced skin erythema in healthy human volunteers and strong antioxidant effect (Bonina et al 2002).…”

Section: Discussionmentioning

confidence: 99%

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Genotoxic and Antimutagenic Effects ofCapparis spinosaL. on theAllium cepaL. Root Tip Meristem Cells

Sultan

Çelik

2009

Caryologia

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Section: Discussionmentioning

confidence: 99%

“…et al 2002;Germanò et al 2002), and the potential use in oxidative stress-based pathological conditions has been suggested (Bonina. et al 2002;Panico et al 2005). On the other hand, the antioxidative potential of the edible caper is less known.…”

Section: Genotoxic and Antimutagenic Effects Of Capparis Spinosa L Omentioning

confidence: 99%

Genotoxic and Antimutagenic Effects ofCapparis spinosaL. on theAllium cepaL. Root Tip Meristem Cells

Sultan

Çelik

2009

Caryologia

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“…It is used for arteriosclerosis, as a diuretic, kidney disinfectant and vermifuge (Soyler and Khawar 2007). In more recent investigations, aqueous extracts of C. spinosa exhibited several pharmacological activities, including antifungal (Ali-Shtayeh and Abu Ghdeib 1999), anti-Leishmania (Jacobson and Schlein 1999), antibacterial (Mahasneh 2002), anti-hyperglycaemic (Eddouks et al 2004), chondrocyte-protective (Panico et al 2005), hypolipidaemic (Eddouks et al 2005), anti-allergenic, anti-histaminic (Trombetta et al 2005), antiviral and immuno-modulatory (Arena et al 2008) activities.…”

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confidence: 99%

Potential anthelmintic effect of Capparis spinosa (Capparidaceae) as related to its polyphenolic content and antioxidant activity

Akkari¹,

B’chir²,

Hajaji³

et al. 2016

Vet. Med. - Czech

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ABSTRACT:Capparis spinosa is cultivated for several proprieties and the different parts of the plant (flower buds, fruits, leaf and seeds) have been employed in drugs, foods and cosmetics. This study aimed to explore the antioxidant potential effect and to assess the anthelmintic efficacy of an aqueous extract of Capparis spinosa. In vitro antioxidant activity of aqueous extracts from the fresh leaves and flower buds of C. spinosa was measured by determining free radical-scavenging activity against DPPH and ABTS radical cations. In vitro anthelmintic activities against eggs and adult worms of Haemonchus contortus from sheep were investigated in comparison to albendazole. DPPH and ABTS activities of both aqueous extracts increased in a dose dependent manner. The IC 50 values of aqueous extracts from fresh leaves, flowers buds and ascorbic acid in the DPPH radical scavenging assay were 101.40; 70.40 and 57.56 μg/ml, respectively. The IC 50 values of aqueous extracts fresh leaves, flowers buds and ascorbic acid in the ABTS radical scavenging assay were 110; 87.89 and 58.17 μg/ml, respectively. Both plant extracts showed ovicidal activity at all tested concentrations. The aqueous extract from flower buds (IC 50 = 2.76 mg/ml) showed higher inhibitory effects (P < 0.05) than aqueous extract from leaves (IC 50 = 8.54 mg/ml) in the egg hatching assay. The aqueous extract from flower buds inhibited more worms than the aqueous extract from leaves at all tested concentrations. After 6 h of exposure, the highest tested concentrations of aqueous extracts from flower buds and leaves induced 100 and 41.66% inhibition of motility, respectively. These results show for the first time that C. spinosa possesses in vitro anthelmintic properties which may be related to its high content of phenolic compounds such as flavonoids and tannins. Keywords: Capparis spinosa; free radical-scavenging ability; anthelmintic; Haemonchus contortusList of abbreviations ABTS = 2,2'-azinobis-[3-ethylbenzthiazoline-6-sulfonic acid]; DMSO = dimethyl sulfoxide; DPPH = 2,2-diphenyl-1-picrylhydrazyl; HPLC/MS = chromatography/mass spectrometry; PBS = phosphate-buffered saline Parasite infestations of livestock species are especially prevalent in developing countries due to poor management practices and inadequate control measures (Dhar et al. 1982). The main control measures for parasitic diseases largely rely on the repeated use of anthelmintics. However, resistance to various groups of anthelmintics is constantly increasing in worm populations, especially those found in small ruminants (Waller 1997;Van Wyk et al. 1999). In addition, the increasing pressure from consumers to limit the use of chemical substances in livestock industry merits consideration. These two issues underpin the current search for alternatives or rather complementary solutions to chemotherapy to control gastrointestinal parasitism in sheep and goats. There is an increasing body of evidence that stockowners rely on ethno-veterinary medicine as an alternative and as a sustain-

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“…According to ethnopharmacological data collected in the southeastern region of Morocco, CS is alleged to possess a hypoglycaemic effect, which has been experimentally demonstrated [7,8] . Furthermore, it has been reported that some species of the genus Capparis possess molluscicidal activity [9] , chonroprotective effect [10] and in vitro antitumour effect [11] . Nevertheless, there is no scientific report on the in vitro vascular effect of CS.…”

Section: Pharmacologicalmentioning

confidence: 99%

Cardiovascular Effect of Capparis spinosa Aqueous Extract. Part VI: In vitro Vasorelaxant Effect

Zeggwagh¹,

Michel²,

Eddouks³

2007

American J. of Pharmacology and Toxicology

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Abstract:The aim of this study was to investigate the in vitro vasorelaxanteffect of Capparis spinosa Aqueous Extract (CSAE) at a dose of 10 mg mL −1 . Aortic rings isolated from normal wistar rats were used. The addition of CSAE during the plateau phase of contraction, induced by noradrenaline and KCl, produced a rapid relaxation. Incubation of aortic ring with CSAE during 30 min shifted the noradrenaline induced dose response curve (p<0.001) and the maximum response (p<0.001) was attenuated indicating that antagonist effect of the α1 adrenoreceptors was non-competitive. However, endothelium remove significantly reduced the vasorelaxant effect of CSAE (p<0.01). Furthermore, nitric oxide inhibition reduced the vasorelaxant effect of CSAE. However, cyclo-oxygenase inhibition did not affect the vasorelaxant effect of CSAE (p<0.05). Inhibition of L-type voltage dependent Ca2+ channels did not reduce the observed CSAE vasorelaxant effect (p<0.05). We conclude that CSAE at a dose of 10 mg mL −1 possess in vitro vasorelaxant effect which may by mediated via an α1 adrenoreceptors antagonism and/or modulation of nitric oxide synthesis.

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Protective effect of Capparis spinosa on chondrocytes

Cited by 110 publications

References 25 publications

Genotoxic and Antimutagenic Effects ofCapparis spinosaL. on theAllium cepaL. Root Tip Meristem Cells

Genotoxic and Antimutagenic Effects ofCapparis spinosaL. on theAllium cepaL. Root Tip Meristem Cells

Potential anthelmintic effect of Capparis spinosa (Capparidaceae) as related to its polyphenolic content and antioxidant activity

Cardiovascular Effect of Capparis spinosa Aqueous Extract. Part VI: In vitro Vasorelaxant Effect

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