Protective effect of boric acid against carbon tetrachloride–induced hepatotoxicity in mice

İnce, Sinan; Keleş, Hikmet; Erdoğan, Metin; Hazman, Ömer; Küçükkurt, İ̇smail

doi:10.3109/01480545.2011.607825

Cited by 64 publications

(29 citation statements)

References 46 publications

(39 reference statements)

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“…From the previous studies, serum AST activity was decreased by 100, 200 and 400 mg boron/kg feed supplementation in layer hens (Eren and Uyanik, 2007). The AST in rats (Hunt and Herbel, 1991) and both AST activities in mice (Ince et al, 2012) were also decreased by Boron. According to Hunt and Herbel (1991) and Ince et al (2012), the decreases in AST and ALT enzymes activities by Boron supplementation may result from the protective effects of the Boron on normal liver metabolism.…”

Section: Blood Biochemical Constituentsmentioning

confidence: 99%

“…The AST in rats (Hunt and Herbel, 1991) and both AST activities in mice (Ince et al, 2012) were also decreased by Boron. According to Hunt and Herbel (1991) and Ince et al (2012), the decreases in AST and ALT enzymes activities by Boron supplementation may result from the protective effects of the Boron on normal liver metabolism. The same finding was found by Eren et al (2012) when they fed broiler chicks on 500, 750 and 1000 mg boron/kg feed.…”

Section: Blood Biochemical Constituentsmentioning

confidence: 99%

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Dietary Boron Supplementation and its Impact on Semen Characteristics and Physiological Status of Adult Male Rabbits

Elkomy¹,

El-Hady²,

Elghalid³

2015

Asian J. of Poultry Science

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This study was carried out to assess the effect of Boron supplementation on male rabbit's reproductive performance. A total of 20 V. Line (V.L) adult rabbit bucks were divided into four equal experimental groups (5 bucks for each). Groups 2, 3 and 4 were fed rations supplemented with 17.5, 35 and 70 mg boron/kg feed in the form of boric acid (100, 200 and 400 mg boric acid, respectively) over 8 weeks. The first group was served as a control group. Results obtained by the Boron groups revealed that adding Boron to rabbit bucks rations at any tested doses resulted in a non-significant increase in the ejaculate volume of male rabbit by approximately 25% above the control group. Adding Boron at any dose exhibited a significant increase (p#0.01) in sperm concentration, total sperm output, sperm motility, live sperm and normal sperm compared to the control group and the high Boron dose had the highest effect on previous measurements compared to the low and medium Boron doses. Opposite trend was shown in the reaction time (libido) and seminal plasma fructose concentration which showed a significant decrease in these parameters in the Boron treated groups compared to the control. Plasma total protein, glucose, total lipids and triglycerides concentration were boosted in the Boron groups compared to the control (p#0.01) for glucose and triglycerides measurements. On the contrary, treated male rabbits with Boron at any tested doses resulted in a significant reduction in plasma cholesterol concentration. Blood and seminal plasma AST and ALT enzymes activities showed a tendency to decrease by Boron treatments compared to the control group. Treating bucks by different Boron doses resulted in a significant increase (p#0.01) in Total Antioxidant Capacity (TAC) to reach 110, 128 and 163% of blood plasma and 114, 121 and 122% of seminal plasma compared to the control value. On the other side, adding Boron to bucks rations did not affect the activity of seminal plasma alkaline phosphatase enzyme. Blood testosterone hormone had a tendency to increase in the Boron groups compared to the control group but this increase was not significant. It could be concluded that feeding rabbit bucks on rations containing the studied Boron doses results in a significant improvement in semen quality characteristics and had a positive effect on their physiological status.

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Section: Blood Biochemical Constituentsmentioning

confidence: 99%

Section: Blood Biochemical Constituentsmentioning

confidence: 99%

Dietary Boron Supplementation and its Impact on Semen Characteristics and Physiological Status of Adult Male Rabbits

Elkomy¹,

El-Hady²,

Elghalid³

2015

Asian J. of Poultry Science

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“…It has been definitely proved that the antioxidant system of the rats is altered after IR treatment. These enzymes work together to eliminate active oxygen species, and small deviations in physiological concentrations may have a dramatic effect on the resistance of cellular lipids, proteins and DNA to oxidative damage (Ince et al, 2012). As a result, the activity of these antioxidant enzymes is essential for protection against oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Myocardium Protective Function of Salvianolic Acid B in Ischemia Reperfusion Rats

Qiao

2016

Afr J Tradit Complement Altern Med

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Background: Salvia miltiorrhiza (SM) Bunge is one of the widely-used Chinese medicinal herbs. Salvianolic acid B (Sal B), a bioactive compound isolated from the Chinese herb Radix Salviae Miltiorrhizae, has been reported to exhibit anti-inflammatory and anti-oxidantive effects. Material and method: To study the cardioprotective effects of salvianolic acid B (Sal B) on acute myocardial ischemia reperfusion (MIR) injury rats, on the basis of this investigation, the possible mechanism of salvianolic acid B was elucidated. Male Sprague-Dawley rats (200-220 g) were randomly divided into five groups: sham-operated, MIR, MIR + Sal B (10 mg/kg/day, orally), MIR + Sal B (20 mg/kg/day, orally) and MIR + Sal B (30 mg/kg/day, orally). Before operation, the foregoing groups were pretreated with homologous drug once a day for 7 days, respectively. After twelve hours in MIR, the cardioprotective effects of SPJ were evaluated by infarct size, biochemical values, and the antioxidative and antiapoptotic relative gene expressions. Results: Sal B significantly improved heart function and decreased infarct size; remarkably decreased levels of serum TNF-α and IL-1β levels, increased contents of myocardium antioxidant enzymes activities; western blot results showed that Sal B ameliorate the increased Bax and caspase-3 protins expressions and decreased Bcl-2 proteins expression and ratios of Bcl-2 to Bax. Conclusion: In ischemic myocardium, oxidative stress caused the overgeneration and accumulation of reactive oxygen species (ROS), which was central of cardiac ischemic injury. Sal B exerted beneficially cardioprotective effects on myocardial ischemia injury rats, mainly scavenging oxidative stress-triggered overgeneration and accumulation of ROS, alleviating myocardial ischemia injury and cardiac cell death.

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“…It has been shown that CCl 4 administration increases cholesterol and triglycerides levels [1,[49][50][51] . In the current investigation, an increase in triglyceride level was observed only in the vehicle group in that olive oil was given to the rats.…”

Section: Discussionmentioning

confidence: 99%

Salgı

Karaman¹,

Özen²,

Dağ³

et al. 2016

Kafkas Univ Vet Fak Derg

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Omega-3 is a polyunsaturated fatty acid known to have immunomodulatory functions. In the present study, ameliorative potential of omega-3 in experimental carbon tetrachloride (CCl4) toxicity was investigated. Total of 40 adult male Wistar albino rats were allocated into five groups and were subcutaneously given once every two days for 6 weeks the followings: Group 1 (Control): 0.5 ml/kg serum physiologic, Group 2 (Omega): 0.5 g/kg omega-3, Group 3 (Vehicle): 0.5 ml/kg pure olive oil, Group 4 (CCl4): 0.5 ml/kg CCl4, Group 5 (CCl4 + Omega): 0.5 ml/kg CCl4 plus 0.5 g/kg omega-3. At the end of the treatments, blood samples were collected and necropsy was performed for collection of liver tissues. Serum AST, AlT, GGT, TAC, TOC, triglyceride, and visfatin levels were detected. liver morphology and immunoreactivities against TGF-α, TGF-β, PPAR-α, and PPAR-γ were assessed. Serum AST, AlT, GGT, and TOC levels significantly increased while TAC level decreased in CCl4 given animals as compared to the control group. No significant changes were observed in triglyceride and visfatin levels. Immunohistochemical staining revealed increased TGF-α and TGF-β expressions and decreased PPAR-α and PPAR-γ expressions in liver of CCl4 given animals. Omega-3 supplementation has prominent effects in correcting the biochemical and immunohistochemical parameters studied as well as the tissue morphology. The results of the investigation indicated that omega-3 has ameliorative effects on the oxidative tissue degeneration and inflammatory processes induced by CCl4 treatment in rats. Keywords: CCl4, Omega-3, TGF-α, TGF-β, PPAR-α, PPAR-γ Karbon Tetraklorür Toksikasyonunda Omega-3'ün Koruyucu Etkisi ÖzetOmega-3 bağışıklığı düzenleyici fonksiyonları olduğu bilinen çoklu doymamış bir yağ asididir. Bu çalışmada, deneysel karbon tetraklorür (CCl4) toksikasyonunda omega-3'ün koruyucu potansiyel etkisi araştırılmıştır. Toplam 40 adet ergin erkek Wistar albino rat eşit beş gruba ayrıldı ve 6 hafta süresince her iki günde bir olmak üzere subkutan yolla deneklere tarif edilen uygulamalar yapıldı; Grup 1 (kontrol): 0.5 ml/kg serum fizyolojik, Grup 2 (Omega): 0.5 g/kg omega-3, Grup 3 (Taşıt): 0.5 ml/kg saf zeytin yağı, Grup 4 (CCl4): 0.5 ml/kg CCl4, Grup 5 (CCl4 + Omega): 0.5 ml/kg CCl4 artı 0.5 g/kg omega-3. Araştırma süresinin sonunda, kan örnekleri alınan deneklere karaciğer doku örneklerinin toplanması amacıyla nekropsi uygulandı. Serum AST, AlT, GGT, TAC, TOC, trigliserid ve visfatin seviyeleri belirlendi. Karaciğer morfolojisi incelendi ve TGF-α, TGF-β, PPAR-α ve PPAR-γ immunreaktiviteleri tespit edildi. Kontrol grubu ile karşılaştırıldığında CCl4 verilen hayvanlarda serum AST, AlT, GGT ve TOC seviyelerinin anlamlı derecede arttığı, TAC seviyesinin ise azaldığı gözlemlendi. Trigliserid ve visfatin seviyelerinde anlamlı bir değişikliğin olmadığı belirlendi. İmmunohistokimyasal boyamalarda CCl4 verilen hayvanlarda TGF-α ve TGF-β immunreaktiviteleri artarken PPAR-α ve PPAR-γ immunreaktivitelerinde azalma dikkati çekti. Omega-3 takviyesinin incel...

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Protective effect of boric acid against carbon tetrachloride–induced hepatotoxicity in mice

Cited by 64 publications

References 46 publications

Dietary Boron Supplementation and its Impact on Semen Characteristics and Physiological Status of Adult Male Rabbits

Dietary Boron Supplementation and its Impact on Semen Characteristics and Physiological Status of Adult Male Rabbits

Myocardium Protective Function of Salvianolic Acid B in Ischemia Reperfusion Rats

Salgı

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