Protective effect of binaphthyl diselenide, a synthetic organoselenium compound, on 2‐nitropropane‐induced hepatotoxicity in rats

Ibrahim, Mohammad; Prigol, Marina; Hassan, Waseem; Nogueira, Cristina W.; Rocha, João Batista Teixeira da

doi:10.1002/cbf.1645

Cited by 25 publications

(13 citation statements)

References 42 publications

(72 reference statements)

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“…Studies have suggested that organoselenium compounds could be considered potential antioxidant and neuroprotective compounds 6–8. Our research group has demonstrated the neuroprotective properties of different organoselenium compounds against some models of neural injury 9–12.…”

Section: Introductionmentioning

confidence: 90%

Neuroprotector effect of p,p'‐methoxyl‐diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism

Pinton

Rocha

Gai

et al. 2011

Cell Biochemistry & Function

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The present study investigated whether the antioxidant activity of p,p'-methoxyl-diphenyl diselenide [(MeOPhSe)(2)] is involved in its protective effect against cognitive impairment induced by streptozotocin (STZ) in a model of sporadic dementia of Alzheimer's type (SDAT). Swiss mice were treated with STZ or vehicle [2 µl of 2·5 mg ml(-1) solution; intracerebroventricularly (i.c.v.)] twice, 48 h apart. (MeOPhSe)(2) (25 mg kg(-1)) or vehicle was orally administered 30 min prior to each STZ treatment. Neuroprotector effect of (MeOPhSe)(2) on the behavioral performance of mice on spatial recognition memory consolidation was investigated in the Y-maze test. After that, mouse brains were removed for measuring antioxidant parameters. (MeOPhSe)(2) protected against the impairment in learning and memory caused by i.c.v. administration of STZ in mice. (MeOPhSe)(2) protected against the increase in reactive species and the reduction of glutathione levels, as well as, the increase in superoxide dismutase and glutathione S-transferase activities caused by STZ in whole brain. These results suggest that antioxidant property is involved, at least in part, in the neuroprotective effect of (MeOPhSe)(2) on SDAT induced by STZ in mice.

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Section: Introductionmentioning

confidence: 90%

Neuroprotector effect of p,p'‐methoxyl‐diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism

Pinton

Rocha

Gai

et al. 2011

Cell Biochemistry & Function

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“…Adding a second phenyl group to diphenyl selenide, converting it in binaphthyl diselenide ( 14 ), revealed that it showed a significant antioxidant activity [ 58 ]. Compound 14 could exert a protective action against 2-nitropropane (2-NP)-induced hepatoxicity in rats.…”

Section: Selenides and Diselenides With Therapeutic Perspectivementioning

confidence: 99%

Selenides and Diselenides: A Review of Their Anticancer and Chemopreventive Activity

et al. 2018

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Selenium and selenocompounds have attracted the attention and the efforts of scientists worldwide due to their promising potential applications in cancer prevention and/or treatment. Different organic selenocompounds, with diverse functional groups that contain selenium, have been reported to exhibit anticancer and/or chemopreventive activity. Among them, selenocyanates, selenoureas, selenoesters, selenium-containing heterocycles, selenium nanoparticles, selenides and diselenides have been considered in the search for efficiency in prevention and treatment of cancer and other related diseases. In this review, we focus our attention on the potential applications of selenides and diselenides in cancer prevention and treatment that have been reported so far. The around 80 selenides and diselenides selected herein as representative compounds include promising antioxidant, prooxidant, redox-modulating, chemopreventive, anticancer, cytotoxic and radioprotective compounds, among other activities. The aim of this work is to highlight the possibilities that these novel organic selenocompounds can offer in an effort to contribute to inspire medicinal chemists in their search of new promising derivatives.

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“…Several reviews from our laboratory have focused on this topic [159-161]. Briefly, organoselenium compounds have been shown to possess glutathione peroxidase-mimetic activity [162-166], lipid peroxidation/radical-scavenging/peroxynitrite-scavenging activity [167-171], thioredoxin reductase-like activity [172-176], antiinflammatory and antinociceptive activity [177-181], antinociceptive activity [182-186], hepatoprotective activity [187-191], gastroprotective activity [192-196], nephroprotective activity [197-201], cardioprotective activity [202-206], insulin-mimetic activity [207-211], and neuro-protective activity [212-218] (Scheme 3 ).…”

Section: Future Directionsmentioning

confidence: 99%

Association of Oxidative Stress to the Genesis of Anxiety: Implications for Possible Therapeutic Interventions

Hassan¹,

Silva²,

Mohammadzai³

et al. 2014

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Oxidative stress caused by reactive species, including reactive oxygen species, reactive nitrogen species, and unbound, adventitious metal ions (e.g., iron [Fe] and copper [Cu]), is an underlying cause of various neurodegenerative diseases. These reactive species are an inevitable by-product of cellular respiration or other metabolic processes that may cause the oxidation of lipids, nucleic acids, and proteins. Oxidative stress has recently been implicated in depression and anxiety-related disorders. Furthermore, the manifestation of anxiety in numerous psychiatric disorders, such as generalized anxiety disorder, depressive disorder, panic disorder, phobia, obsessive-compulsive disorder, and posttraumatic stress disorder, highlights the importance of studying the underlying biology of these disorders to gain a better understanding of the disease and to identify common biomarkers for these disorders. Most recently, the expression of glutathione reductase 1 and glyoxalase 1, which are genes involved in antioxidative metabolism, were reported to be correlated with anxiety-related phenotypes. This review focuses on direct and indirect evidence of the potential involvement of oxidative stress in the genesis of anxiety and discusses different opinions that exist in this field. Antioxidant therapeutic strategies are also discussed, highlighting the importance of oxidative stress in the etiology, incidence, progression, and prevention of psychiatric disorders.

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Protective effect of binaphthyl diselenide, a synthetic organoselenium compound, on 2‐nitropropane‐induced hepatotoxicity in rats

Cited by 25 publications

References 42 publications

Neuroprotector effect of p,p'‐methoxyl‐diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism

Neuroprotector effect of p,p'‐methoxyl‐diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism

Selenides and Diselenides: A Review of Their Anticancer and Chemopreventive Activity

Association of Oxidative Stress to the Genesis of Anxiety: Implications for Possible Therapeutic Interventions

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