Protective effect of bacillopeptidase CFR5 from Bacillus subtilis CFR5 on cerulein-induced pancreatitis

Sharmila, G.R.; Venkateswaran, G.

doi:10.1016/j.bbrc.2017.07.054

Cited by 5 publications

(1 citation statement)

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“…Several tight junction-related proteins have been identified, and zonula occludens (ZO)-1 is the most widely used structural marker for tight junctions. It has been shown that the expression of ZO-1 is downregulated in AP and the expression of ZO-1 is negatively correlated with the degree of inflammation ( Sharmila and Venkateswaran, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway

Liu

Tian

et al. 2022

Front. Cell Dev. Biol.

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Ubiquitin-specific protease 25 (USP25) plays an important role in inflammation and immunity. However, the role of USP25 in acute pancreatitis (AP) is still unclear. To evaluate the role of USP25 in AP, we conducted research on clinical AP patients, USP25wild-type(WT)/USP25 knockout (USP25−/−) mice, and pancreatic acinar cells. Our results showed that serum USP25 concentration was higher in AP patients than in healthy controls and was positively correlated with disease severity. AP patients’ serum USP25 levels after treatment were significantly lower than that at the onset of AP. Moreover, USP25 expression was upregulated in cerulein-induced AP in mice, while USP25 deficiency attenuates AP and AP-related multiple organ injury. In vivo and in vitro studies showed that USP25 exacerbates AP by promoting the release of pro-inflammatory factors and destroying tight junctions of the pancreas. We showed that USP25 aggravates AP and AP-related multiple organ injury by activating the signal transducer and activator of transcription 3 (STAT3) pathway. Targeting the action of USP25 may present a potential therapeutic option for treating AP.

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Section: Introductionmentioning

confidence: 99%