Protective effect of B.clasuii on sepsis

Abstract

Aim: Sepsis is a clinical problem that still has high mortality and morbidity despite advances in supportive care in intensive care. The study's aim was to investigate the protective effect of Bacillus clausii, an important probiotic with a strengthening effect on the gastrointestinal barrier, on septicemia. Material and Method: Twenty-four rats were divided into three randomized and double-blind groups, as Group 1 (control group, n=8), Group 2 (sepsis group, n=8), and Group 3 (sepsis+probiotic group, n=8). Lipopolysaccharide extracted from serotypes (0111:B4) of Escherichia coli (E.coli ) was injected intraperitoneally to all group for sepsis model at a dose of 15 mg/kg and rats were sacrificed at 48 hours. Serum oxidant and antioxidant parameters were measured. Results:

The Protective Role of Probiotics in Sepsis Induced Rats

“…creased permeability in sepsis is considered one of the most important factors that worsen the situation and probiotics are believed to be protective. [7] Lactobacillus rhamnosus GG (LGG) is one of the most studied probiotics on this subject. [8] Investigating the protective effect of LGG, which is an important probiotic with gastrointestinal barrier strengthening effect on sepsis in prophylactic use, was this study's aim.…”