Protective effect of aspirin following acute coronary artery occlusion

Reiser, Joseph; Gough, William B.; Anderson, Gary J.

doi:10.1016/0002-9149(80)90806-1

Cited by 2 publications

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“…Aspirin has been shown to be antiarrhythmic in dogs subjected to non-thrombotic coronary occlusion (Moschos, Haider, De La Cruz, Lyons & Regan, 1978;Reiser, Gough & Anderson, 1980;Coker, Ledingham, Parratt & Zeitlin, 198 lb). These results are in agreement with those described here.…”

Section: Discussionmentioning

confidence: 99%

THE EFFECTS OF PROSTAGLANDINS E₂, F_2α, PROSTACYCLIN, FLURBIPROFEN AND ASPIRIN ON ARRHYTHMIAS RESULTING FROM CORONARY ARTERY LIGATION IN ANAESTHETIZED RATS

Coker

Parratt

1981

British J Pharmacology

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1 Various prostaglandins and inhibitors of prostaglandin synthesis were administered prior to acute coronary artery ligation in anaesthetized rats and their effects were assessed on the number and severity of the resulting early arrhythmias (ventricular ectopic activity; incidence and duration of ventricular tachycardia and of ventricular fibrillation). 2 Prostaglandin E2 (PGE2), PGF2c and prostacyclin all showed antiarrhythmic activity; in contrast flurbiprofen increased the incidence of ventricular fibrillation and mortality. 3 Both the number of ventricular ectopic beats and the incidence of ventricular fibrillation were reduced by aspirin.4 The results suggest that the release of endogenous PGE2, PGF2", and prostacyclin could reduce early post-infarction ventricular arrhythmias whilst the protective effect of aspirin in this model adds further support for the hypothesis that thromboxane release is involved in the genesis of these arrhythmias.

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Section: Discussionmentioning

confidence: 99%

THE EFFECTS OF PROSTAGLANDINS E₂, F_2α, PROSTACYCLIN, FLURBIPROFEN AND ASPIRIN ON ARRHYTHMIAS RESULTING FROM CORONARY ARTERY LIGATION IN ANAESTHETIZED RATS

Coker

Parratt

1981

British J Pharmacology

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Early Ventricular Arrhythmias Arising from Acute Myocardial Ischaemia; Possible Involvement of Prostaglandins and Thromboxanes

Coker¹

1982

Early Arrhythmias Resulting From Myocardial Ischaemia

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Protective effect of aspirin following acute coronary artery occlusion

Cited by 2 publications

References 0 publications

THE EFFECTS OF PROSTAGLANDINS E₂, F_2α, PROSTACYCLIN, FLURBIPROFEN AND ASPIRIN ON ARRHYTHMIAS RESULTING FROM CORONARY ARTERY LIGATION IN ANAESTHETIZED RATS

THE EFFECTS OF PROSTAGLANDINS E₂, F_2α, PROSTACYCLIN, FLURBIPROFEN AND ASPIRIN ON ARRHYTHMIAS RESULTING FROM CORONARY ARTERY LIGATION IN ANAESTHETIZED RATS

Early Ventricular Arrhythmias Arising from Acute Myocardial Ischaemia; Possible Involvement of Prostaglandins and Thromboxanes

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Protective effect of aspirin following acute coronary artery occlusion

Cited by 2 publications

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THE EFFECTS OF PROSTAGLANDINS E2, F2α, PROSTACYCLIN, FLURBIPROFEN AND ASPIRIN ON ARRHYTHMIAS RESULTING FROM CORONARY ARTERY LIGATION IN ANAESTHETIZED RATS

THE EFFECTS OF PROSTAGLANDINS E2, F2α, PROSTACYCLIN, FLURBIPROFEN AND ASPIRIN ON ARRHYTHMIAS RESULTING FROM CORONARY ARTERY LIGATION IN ANAESTHETIZED RATS

Early Ventricular Arrhythmias Arising from Acute Myocardial Ischaemia; Possible Involvement of Prostaglandins and Thromboxanes

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THE EFFECTS OF PROSTAGLANDINS E₂, F_2α, PROSTACYCLIN, FLURBIPROFEN AND ASPIRIN ON ARRHYTHMIAS RESULTING FROM CORONARY ARTERY LIGATION IN ANAESTHETIZED RATS

THE EFFECTS OF PROSTAGLANDINS E₂, F_2α, PROSTACYCLIN, FLURBIPROFEN AND ASPIRIN ON ARRHYTHMIAS RESULTING FROM CORONARY ARTERY LIGATION IN ANAESTHETIZED RATS