Protective effect of Arbutus unedo aqueous extract in carrageenan-induced lung inflammation in mice

Mariotto, Sofia; Esposito, Emanuela; Paola, Rosanna Di; Ciampa, Anna Rosa; Mazzon, Emanuela; Prati, Alessandra Carcereri de; Darra, Elena; Vincenzi, Simone; Cucinotta, G.; Caminiti, Rocco; Suzuki, Hisanori; Cuzzocrea, Salvatore

doi:10.1016/j.phrs.2007.12.005

Cited by 69 publications

(43 citation statements)

References 40 publications

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“…There are few reports in the literature regarding the anti-inflammatory properties of the six tested plant extracts on cytokine release; all these studies reported anti-inflammatory responses [8,20,21,[39][40][41][42][43]. Our results were consistent with previous studies demonstrating that all of the six plant extracts tested showed an inhibitory effect on IL-6 production while most of them attenuated the release of IL-10, but relatively with variable responses and in a dosedependent manner.…”

Section: Discussionsupporting

confidence: 91%

Antimicrobial and anti-inflammatory potential therapy for opportunistic microorganisms

Assaf

Amro

Mashallah

et al. 2016

J Infect Dev Ctries

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Introduction: Methanolic extracts of six plants (Arbutus andrachne, Chrysanthemum coronarium, Inula viscosa, Origanum syriacum, Punica granatum, and Rosmarinus officinalis) used in traditional medicine for the treatment of bacterial and fungal infections were evaluated. The present study was conducted to evaluate the antimicrobial and anti-inflammatory activity of some medicinal plants in lowering the risk of opportunistic infections of the oral cavity caused by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Extracts were evaluated separately and in a mixture. Methodology: The methanolic plant extracts were tested against three opportunistic microorganisms by determining the minimum inhibitory concentration (MIC). They were also evaluated for their ability to suppress the release of the pro-inflammatory cytokine IL-6 while not suppressing the release of the anti-inflammatory cytokine IL-10 from peripheral blood mononuclear cells using ELISA. Results: All extracts showed both antimicrobial and anti-inflammatory activities. However, O. syriacum exhibited the highest antimicrobial activity for the three microorganisms among all of the tested extracts (MIC S. aureus: 1 mg/mL; P. aeruginosa: 2 mg/mL; and C. albicans: 1 mg/mL). The extracts inhibited the expression of the pro-inflammatory cytokine IL-6 with apparent dose-dependent responses while they attenuated the secretion of the anti-inflammatory cytokine IL-10. The mixture of O. syriacum and R. officinalis showed an anti-inflammatory effect, with a synergistic antimicrobial effect. Conclusion: These findings support the idea that a diet rich in plants and herbs may contribute to the reduction of inflammation and microbial growth and may also be preventive against various infections, including those related to the oral cavity.

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Section: Discussionsupporting

confidence: 91%

Antimicrobial and anti-inflammatory potential therapy for opportunistic microorganisms

Assaf

Amro

Mashallah

et al. 2016

J Infect Dev Ctries

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“…unedo, an evergreen wild shrub that grows in the Mediterranean region (10), contains many pharmacologically relevant polyphenols and one of its main phenolic compounds is arbutin (1,11). A. unedo leaf infusions are known to have diuretic, astringent, and uroantiseptic properties and are used in folk medicine for treatment of hypertension, diabetes, and inflammation (12)(13)(14)(15). As phenolic compounds have powerful antioxidative activity, the identification of individual compounds in leaves responsible for pharmacological activity has been the focus of interest in recent years.…”

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confidence: 99%

Quantitative analysis of arbutin and hydroquinone in strawberry tree (Arbutus unedo L., Ericaceae) leaves by gas chromatography-mass spectrometry / Kvantitativna analiza arbutina i hidrokinona u listovima obične planike (Arbutus unedo L., Ericaceae) plinskokromatografskom metodom uz detekciju masenim spektrometrom

Jurica

Karačonji

Šegan

et al. 2015

Archives of Industrial Hygiene and Toxicology

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The phenolic glycoside arbutin and its metabolite with uroantiseptic activity hydroquinone occur naturally in the leaves of various medicinal plants and spices. In this study, an extraction procedure coupled with gas chromatography-mass spectrometry (GC-MS) was developed to determine arbutin and hydroquinone content in strawberry tree (Arbutus unedo L., Ericaceae) leaves. The method showed good linearity (R 2 >0.9987) in the tested concentration range (0.5-200 µg mL), as well as good precision (RSD<5 %), analytical recovery (96.2-98.0 %), and sensitivity (limit of detection=0.009 and 0.004 µg mL -1 for arbutin and hydroquinone, respectively). The results obtained by the validated GC-MS method corresponded well to those obtained by high performance liquid chromatography (HPLC) method. The proposed method was then applied for determining arbutin and hydroquinone content in methanolic leaf extracts. The amount of arbutin in the leaves collected on the island of Koločep (6.82 mg g -1 dry weight) was found to be higher (t paired =43.57, t c =2.92) in comparison to the amount of arbutin in the leaves collected on the island of Mali Lošinj (2.75 mg g -1 dry weight). Hydroquinone was not detected in any of the samples. The analytical features of the proposed GC-MS method demonstrated that arbutin and hydroquinone could be determined alternatively by gas chromatography. Due to its wide concentration range, the method could also be suitable for arbutin and hydroquinone analysis in leaves of other plant families (Rosaceae, Lamiaceae, etc.).

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“…In Oriental Morocco, A. unedo is commonly used in the traditional medicine for the treatment of hypertension and diabetes (Ziyyat et al 1997). It is reported that the leaves of the plant are used as a diuretic, urinary antiseptic, antidiarrheal, anti-inflammatory, antioxidant, astringent and depurative (Pabuçcuoglu et al, 2003;Mariotto et al, 2008;Oliveira et al, 2009). Previous studies have shown that the aqueous extract of A. unedo exhibited vasorelaxant, antidiabetic and antiaggregant actions Mekhfi et al, 2004;Bnouham et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Anti-platelet aggregation effects of extracts from Arbutus unedo leaves

Haouari

Mekhfi

2017

Plant Sci. Today

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It is well known that platelet hyperactivity is a risk factor for cardiovascular diseases such as atherosclerosis, stroke and myocardial infarction. This study aimed to examine the effects of extracts enriched in flavonoids obtained from Arbutus unedo leaves on platelet aggregation. Rat platelets were prepared and incubated in vitro with different doses of the tested extracts, and aggregation was trigged by physiological agonists. Platelet treatment with increasing concentrations (0.1 -1 mg/ml) of diethyl ether extract (genins = free flavonoids) or ethyl acetate extract (hetrosidic flavonoids) inhibited platelet aggregation evoked by thrombin in a concentration-dependant manner. The IC50 values were 0.22 ± 0.03 and 0.36 ± 0.05 mg/ml for genins and heterosidic flavonoids respectively. Treatment with Arbutus unedo extracts also significantly reduced the initial rate of platelet aggregation. At 1 mg/ml, the rate inhibition was 97.8 ± 0.74 and 90.8 ± 1.55 % for genins and heterosidic flavonoids respectively. In addition, flavonoids significantly inhibited platelet aggregation induced by ADP, collagen or epinephrine. We conclude that Arbutus unedo extracts show antiaggregant effects due mainly to flavonoids. These results may partly explain the traditional use of Arbutus unedo leaves for the treatment of cardiovascular disorders such as hypertension.

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Protective effect of Arbutus unedo aqueous extract in carrageenan-induced lung inflammation in mice

Cited by 69 publications

References 40 publications

Antimicrobial and anti-inflammatory potential therapy for opportunistic microorganisms

Antimicrobial and anti-inflammatory potential therapy for opportunistic microorganisms

Anti-platelet aggregation effects of extracts from Arbutus unedo leaves

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