Protective effect of aqueous seed extract of Vitis Vinifera against oxidative stress, inflammation and apoptosis in the pancreas of adult male rats with diabetes mellitus

Adam, Siti Hajar; Giribabu, Nelli; Kassim, Normadiah M.; Kilari, Eswar Kumar; Brahmayya, Manuri; Arya, Aditya; Salleh, Naguib

doi:10.1016/j.biopha.2016.04.032

Cited by 36 publications

(13 citation statements)

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“…Caftaric acid, quercetin-3-O-glucoside and kaempferol-3-O-glucoside were the most abundant phenols present in the hydro-alcoholic extracts; in particular, caftaric acid ranged between 24.92±1.50 µg/g (C1) and 74.93±2.27 µg/g (C2). These results are consistent with other studies, reporting that, if compared with fresh grapes, raisins show higher levels of some flavonoids (such as organic acids and flavonols), due to the removal of water during drying [4,17]. It is noteworthy that Portuguese sample was particularly rich in quercetin-3-O-glucoside (21.68±0.91 µg/g) and kaempferol-3-O-glucoside (16.81±0.49 µg/g).…”

Section: High Performance Liquid Chromatography (Hplc)supporting

confidence: 91%

Phenolic profile and antioxidant activity of different raisin (Vitis viniferaL.) samples

et al. 2016

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Abstract. In the last years, the interest in non-alcoholic grape products, aa potential alternative sources of phenolic compounds, has considerably increased. Raisins are dried grapes largely consumed in the Mediterranean area for the positive pattern of nutrients, and for recent data describing potential benefits on human health. Among the health-promoting substances contained in raisins, flavonoids seem the most interesting. The aim of this study was the application of in vitro methods for the characterization of the phenolic fraction of five samples of raisins, and, in parallel, the evaluation of their antioxidant activity. The methods were: 1) Folin-Cocalteau's assay for the quantification of total polyphenol content; 2) vanillin assay for the measure of flavan-3-ols content; 3) DPPH (1,1,-diphenil-2-picrylhydrazyl) spectrophotometric assay for the assessment of radical scavenging activity; 4) High Performance Thin Layer Chromatography for separation of phenolic substances and assessment of their antioxidant activity; 5) chromatographic separation and quantification of main active substances was performed by HPLC-DAD. Although raisins showed a high variability in their composition, they can be considered as a promising source of phenolic compounds with a significant antioxidant activity for the human diet.

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Section: High Performance Liquid Chromatography (Hplc)supporting

confidence: 91%

Phenolic profile and antioxidant activity of different raisin (Vitis viniferaL.) samples

et al. 2016

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“…Applying phytochemicals as antidiabetic drugs was reported. Adam et al () reported that Vitis Vinifera seed aqueous extract expressed a protective role in the pancreas against oxidative stress, inflammation as well as apoptosis‐caused damage, while conserving pancreatic functions in diabetes. El‐Hadary and Ramadan (, ) reported that cold‐pressed oils showed protective effects against carbon tetrachloride‐induced hepatotoxicity in rats.…”

Section: Discussionmentioning

confidence: 99%

“…The participation of aromatic plants and herbs is enormous to disease prevention (Adam et al, 2016;Almuaigel, Seif, Albuali, Alharbi, & Alhawash, 2017;Assiri, Elbanna, Abulreesh, & Ramadan, 2016;Chahdoura et al, 2017;Rahimi-Madiseh et al, 2017). According to WHO, more than 150 herbs and plants are utilized to treat DM (Hebi, Farid, Ajebli, & Eddouks, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Adam et al (2016) reported that Vitis Vinifera seed aqueous extract expressed a protective role in the pancreas against oxidative stress, inflammation as well as apoptosis-caused damage, while conserving pancreatic functions in diabetes. Ramadan (2016a, 2016b) reported that cold-pressed oils showed protective effects against carbon tetrachloride-induced hepatotoxicity in rats.Chahdoura et al (2017) investigated the hepatoprotective impacts of Opuntia microdasys flowers against induced type 2 diabetes in rats.…”

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confidence: 99%

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Ameliorative impact of cold‐pressedRosmarinus officinalisoil against liver toxicity and genotoxic effects in streptozotocin‐induced diabetic rats and their offspring

et al. 2019

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Diabetes mellitus (DM) is a chronic, lifelong condition threatening human health. Rosmarinus officinalis oil (RO) could have a future role in DM therapy. This study evaluated the composition and antioxidative potential of RO. Antidiabetic traits of RO in streptozotocin (STZ)‐induced diabetic rats was also studied considering the ameliorative impact against embryogenesis defects using in vitro and in vivo biochemical, histological, and genetic assays. RO was investigated for fatty acids and bioactive compounds (tocols and total phenolic compounds), and antiradical potential against DPPH• radicals. The genetic effects were investigated using comet assay and DNA fragmentation test. DM was induced to albino rats by injecting 60 mg/kg of STZ, while RO (100 mg/kg b.w.) was administered. The pregnant animals were divided into four groups; control (C), RO‐treated (RO), diabetic (D), and combined diabetic with RO‐treated (D‐RO). The study was conducted for 180 days. In RO, the contents of polyunsaturated fatty acids, monounsaturated fatty acids, and saturated fatty acids were 42.3%, 41.7%, and 15.8%, respectively. The levels of α‐, β‐, γ‐, and δ‐tocopherols were 280, 20, 1,025, and 35 mg/100 g RO, respectively. RO contained 7.2 mg GAE/g of total phenolic compounds (TPC), while RO quenched 70% of DPPH• radicals. While glucose levels reached the highest in DM rats, treating STZ‐induced diabetic animals with RO‐resoluted serum glucose levels. RO reduced the highest levels of serum chemistry parameters were recorded in DM animals. Histological photographs of maternal and fetus liver exhibited degenerated hepatic cells and congestion central vein. Comet cells and DNA fragments were significantly decreased in D‐RO group comparing to the DM group. RO exhibited antidiabetic capabilities, and thus, it could be utilized as a functional ingredient in novel foods, nutraceuticals, and dietary supplements for diabetic patients. Practical applications RO is rich in bioactive phytochemicals (tocols and phenolic compounds) with antiradical and antihyperglycemic capabilities. Tocols and phenolics are active in radical scavenging of reactive nitrogen species (i.e., peroxynitrite and nitrogen dioxide), and in the prevention of DNA bases nitration. Our results demonstrated that RO could improve the disturbed metabolism of carbohydrate in STZ‐diabetic animals. The potential mode of action of bioactive compounds in RO most likely encompasses the intracellular pathway involved in glucose homeostasis or insulin signaling. In addition, the suppression of oxidative stress by phenolic compounds could provide to the antidiabetic impacts of RO. Our data supported that RO could be utilized to ameliorate DM. Protection with RO directed high protection of the maternal organs and offspring against the oxidative stress of diabetes due to the antihyperlipidemic effects and the antioxidant capabilities of RO.

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“…Grape seed proanthocyanidins were also effective in rat pancreas intoxicated with cadmium [39]. The treatment with grape seed proanthocyanidins reduced blood glucose level, increased plasma insulin and mitigated oxidative stress-related markers [39,40]. Grape seed proanthocyanidins also protected pancreatic tissue by anti-inflammatory action and inhibiting apoptosis [39,41].…”

Section: Pancreasmentioning

confidence: 99%

Are Grapes Able to Mitigate the Noxious Effects Induced by Cadmium Exposure in Different Tissues and/or Organs? A Mini Review

et al. 2018

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Grapes are fruits that grow in clusters and can be crimson, black, dark blue, yellow, green, orange, and pink. Cadmium is a non-essential metal toxic to living organisms and the environment. Recently, health professionals, food scientists, and consumers have paid much attention to grapes for their health-promoting effects. To the best of our knowledge, there are no reviews describing the ability of grapes to mitigate the toxic effects induced by cadmium exposure in different tissues and/or organs. Herein, the aim of this review is to present the effects of grapes following cadmium exposure on the number of papers published in the scientific literature. The results showed that grapes are able to mitigate the harmful activities induced by exposure to cadmium in several tissues and organs. The main actions are closely related to tissue regeneration as a result of the reestablishment of morphology and antioxidant activity. However, further studies are welcomed in order to elucidate new biological pathways regarding the outcomes promoted by grapes in this context, specially related to inflammation, tissue regeneration and cellular death.

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Protective effect of aqueous seed extract of Vitis Vinifera against oxidative stress, inflammation and apoptosis in the pancreas of adult male rats with diabetes mellitus

Cited by 36 publications

References 36 publications

Phenolic profile and antioxidant activity of different raisin (Vitis viniferaL.) samples

Phenolic profile and antioxidant activity of different raisin (Vitis viniferaL.) samples

Ameliorative impact of cold‐pressedRosmarinus officinalisoil against liver toxicity and genotoxic effects in streptozotocin‐induced diabetic rats and their offspring

Are Grapes Able to Mitigate the Noxious Effects Induced by Cadmium Exposure in Different Tissues and/or Organs? A Mini Review

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