Protective effect of aqueous Curry leaf (Murraya koenigii) extract against cadmium-induced oxidative stress in rat heart

Mitra, Elina; Ghosh, Arnab; Ghosh, Dibyajyoti; Mukherjee, Dilip; Chattopadhyay, Aindrila; Dutta, Santanu; Pattari, Sanjib; Bandyopadhyay, Debasish

doi:10.1016/j.fct.2012.01.048

Cited by 88 publications

(54 citation statements)

References 61 publications

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“…Protective mechanisms against Cd‐induced oxidative stress of aqueous curry leaf ( Murraya koenigii ) extract, with a higher flavonol profile, may include chelation with Cd (Fig. ) …”

Section: Mechanism Of Dietary Flavonoids Against Cd‐induced Toxicitymentioning

confidence: 97%

“…demonstrated that naringenin and isoquercitrin had nephroprotective effects in Cd‐induced renal damage via its antioxidant and metal‐chelating properties. Coadministration of naringenin with Cd considerably increased the levels of the renal antioxidant defense system (total sulfhydryl groups, SOD, CAT, GPx, GST, GR, and G6PD) in Cd‐treated rats . Wen et al .…”

Section: Mechanism Of Dietary Flavonoids Against Cd‐induced Toxicitymentioning

confidence: 99%

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Cytoprotective effects of dietary flavonoids against cadmium‐induced toxicity

Jiang

Sun

et al. 2017

Annals of the New York Academy of Sciences

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Cadmium (Cd) damages the liver, kidney, bones, reproductive system, and other organs. Flavonoids, such as anthocyanins and flavonols, which are commonly found in plant foods, have shown protective effects against Cd-induced damage. The cytoprotective effects of flavonoids against Cd-induced diseases are mainly attributable to three mechanisms. First, flavonoids clear reactive oxygen species, thereby reducing lipid peroxide production and improving the activity of antioxidation enzymes. Second, flavonoids chelate Cd, thus reducing the accumulation of Cd and altering the levels of other essential metal ions in vivo. Third, flavonoids reduce DNA damage and inhibit apoptosis. In addition, flavonoids were found to inhibit inflammation and fibrosis and improve glycometabolism and the secretion of reproductive hormones. We introduce the daily dosage and absorption rate of flavonoids and then focus on their bioactive effects against Cd-induced toxicity and reveal the underlying metabolic pathway, which provides a basis for further study of the nutritional prevention of Cd-induced injury. In particular, a better understanding is needed of the structure-activity relationship of flavonoids against Cd toxicity, which has not yet been reported.

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“…Protective mechanisms against Cd‐induced oxidative stress of aqueous curry leaf ( Murraya koenigii ) extract, with a higher flavonol profile, may include chelation with Cd (Fig. ) …”

Section: Mechanism Of Dietary Flavonoids Against Cd‐induced Toxicitymentioning

confidence: 97%

Section: Mechanism Of Dietary Flavonoids Against Cd‐induced Toxicitymentioning

confidence: 99%

Cytoprotective effects of dietary flavonoids against cadmium‐induced toxicity

Jiang

Sun

et al. 2017

Annals of the New York Academy of Sciences

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“…As free radical scavengers, GR, TRX, and SOD1 play very important roles in eliminating kinds of ROS and RNS induced by Cd and maintain the redox balance [9][10][11]. And as a transcription factor, Nrf-2 regulates the transcription of its downstream antioxidant (such as CAT, TRX) or phase II detoxifying enzyme genes [12], thus protecting cells from oxidative stress or other toxic substances [13][14][15].…”

Section: Cdcl 2 Abated the Tacs Of Serum And Placenta Tissuementioning

confidence: 99%

Increased Oxidative DNA Damage in Placenta Contributes to Cadmium-Induced Preeclamptic Conditions in Rat

Zhang

Lin

et al. 2015

Biol Trace Elem Res

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To explore the possible mechanisms of cadmium (Cd)-induced preeclamptic conditions in rats. In the present study, we introduced the in vivo model of preeclampsia by giving intraperitoneal injections of cadmium chloride (CdCl2) to pregnant rats from gestational day (GD) 4 to 19. Maternal body weights were recorded on GD 0, 14, and 20, while their systolic blood pressures (SBPs) monitored on GD 3, 11, and 18. On GD 20, rats were sacrificed and the specimens were collected. The morphological changes of placenta and kidney tissues of pregnant rats were examined by hematoxylin and eosin staining assay. Blood Cd level was detected by inductively coupled plasma mass spectrometry. Total antioxidant capacity (TAC) was evaluated using FRAP method and total nitrite (NOx) was detected with Griess reagent. Antioxidative factors and DNA damage/repair biomarkers were measured by real-time qPCR, western blot or immunohistochemistry study. The current results showed that CdCl2-treated pregnant rats developed preeclampsia (PE)-like manifestations, such as hypertension, albuminuria, with decreased TAC and increased blood Cd level, and pro-oxidative/antioxidative or DNA damage/repair biomarkers. Our study demonstrated that increased oxidative DNA damage in placenta could contribute to Cd-induced preeclamptic conditions in rat.

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“…The aqueous leaf extract of M. koenigii has been shown to reduce lipid peroxidation and to decrease cellular damage, thereby protecting the liver from ethanol-induced toxicity [7]. A recent study has reported that the aqueous extract of M. koenigii protects rat cardiac tissue against cadmium-induced oxidative stress possibly through its antioxidant activity [8]. Another study has demonstrated that hydroethanolic leaf extract of M. koenigii possesses hepatoprotective potential [9].…”

Section: Introductionmentioning

confidence: 97%