Protective effect of apigenin on ovariectomy-induced bone loss in rats

Park, Jeong A; Ha, Sang Keun; Kang, Tong Ho; Oh, Myung Sook; Cho, Min Hyoung; Lee, Soo Yeol; Park, Ji-Ho; Kim, Sun Yeou

doi:10.1016/j.lfs.2008.03.021

Cited by 70 publications

(49 citation statements)

References 52 publications

(50 reference statements)

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“…Decreased BMD is one of the major factors jeopardizing bone strength, resulting in increased susceptibility to fractures (30). The present study revealed that OVX reduced BMD in the dis tal femurs of female SD rats, which are rich in trabecular bone, whilst treatment with icariin prevented these decreases in BMD.…”

Section: Discussionsupporting

confidence: 50%

Effect of icariin on fracture healing in an ovariectomized rat model of osteoporosis

Cao

Zhang

Qian

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Osteoporosis is frequently asymptomatic, presenting a significant clinical and economic burden, particularly following an osteoporosis-associated fracture. Icariin has been reported to inhibit osteoporosis in vitro, and the present study investigated whether icariin also promoted bone fracture healing in ovariectomized osteoporotic (OVX) rats in vivo. A total of 30 female rats were randomly divided into three groups (n=10 per group): i) Sham surgery; ii) OVX; and iii) OVX with icariin (OVX + ICA) groups. At 3 months after the ovariectomy, a unilateral cross-tibia fracture was made at the proximal right tibia. Animals were then sacrificed after 5 weeks of oral treatment. X-rays were taken at 1 week, 3 weeks and 5 weeks of treatment, and dual energy X-ray absorptiometry was used to measure the bone mineral density (BMD). Changes to the osteocalcin (BGLAP), alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP) and estradiol levels in blood were measured. Callus formation and bone union were observed, the BMD was significantly higher and the BGLAP, ALP and TRAP levels were reduced, but no significant increase was observed in the blood estradiol level in the OVX + ICA group compared with the OVX group. The present findings indicate that icariin has potential as a novel alternative therapeutic agent for fracture healing in postmenopausal osteoporosis.

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Section: Discussionsupporting

confidence: 50%

Effect of icariin on fracture healing in an ovariectomized rat model of osteoporosis

Cao

Zhang

Qian

et al. 2017

Experimental and Therapeutic Medicine

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“…Therefore, it would be useful to study the interaction between C. wilfordii and ERs. Bone loss is a major factor jeopardizing bone integrity, resulting in reduced bone strength and increased susceptibility to fracturing [34]. BMD is the gold standard for evaluating individuals who are at risk for osteoporosis because it best predicts the fracture risk in people without previous fractures [35].…”

Section: Discussionmentioning

confidence: 99%

Bone regenerative effect of aqueous Cynanchum wilfordii extract in receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation and estrogen deficiency-induced osteoporosis

Jun

Choi

Lee

et al. 2017

ijpm

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A b s t r a c tOsteoporosis increases with age, most frequently in postmenopausal women because of reduced ovarian hormone levels. Furthermore, estrogen deficiency impairs trabecular metaphyseal bone. Although estrogen herbal therapies maybe safer alternatives. Therefore, the aim of this study the effects of aqueous extracts factor mediated osteoporosis tartrate cells. We investigated the osteoprotective effect of CWW in an ovariectomized (OVX) Sprague Dawley rat model doses (100, 200, and 400 mg/kg). After a 24 were not affected except in the OVX/E2 group. Additionally, bone mineral density (BMD) and histological analyses significantly higher group rats. collagen type I C results show that compar the OVX model. Taken together, CWW exhibited inhibitory effects on osteoclastogenesis vitro,

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“…Decreased BMD is one of the major factors jeopardizing bone strength, resulting in increased susceptibility to fractures [26]. Thus, BMD measurement can best predict fracture risk [27].…”

Section: Discussionmentioning

confidence: 99%

<i>Caulis Lonicerae</i> Japonicae extract shows protective effect on osteoporosis in rats

Li¹,

Mu²

2017

Trop. J. Pharm Res

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Protective effect of apigenin on ovariectomy-induced bone loss in rats

Cited by 70 publications

References 52 publications

Effect of icariin on fracture healing in an ovariectomized rat model of osteoporosis

Effect of icariin on fracture healing in an ovariectomized rat model of osteoporosis

Bone regenerative effect of aqueous Cynanchum wilfordii extract in receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation and estrogen deficiency-induced osteoporosis

<i>Caulis Lonicerae</i> Japonicae extract shows protective effect on osteoporosis in rats

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