Protective Effect of Antioxidant Ebselen (PZ51) on the Cerebral Cortex of Stroke-Prone Spontaneously Hypertensive Rats

Sui, Hui; Wang, Wen; Wang, Pei He; Liu, Lisheng

doi:10.1291/hypres.28.249

Cited by 24 publications

(15 citation statements)

References 34 publications

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“…Phenolic compounds such as resveratrol are potent antioxidants and have been reported to be protective against neuronal apoptosis associated with the pathogenesis of Alzheimer's disease (72). Experimental and clinical studies showed that ebselen (PZ51), a GPX mimetic that can inhibit lipid peroxidation and decrease iNOS expression, was shown to suppress cell death of cortical neurons and prevent cerebral ischemia (stroke) in clinical trials (290,337). Mitochondria-targeted antioxidants such as MitoQ and MitoVitamin E were developed as pharmaceutical products for prevention of stroke and cardiovascular disease (321).…”

Section: Antioxidants For Prevention Of Degenerative Diseasesmentioning

confidence: 99%

Redox Regulation of Cell Survival

Trachootham

Ogasawara

et al. 2008

Antioxidants & Redox Signaling

1,529

1,177

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Section: Antioxidants For Prevention Of Degenerative Diseasesmentioning

confidence: 99%

Redox Regulation of Cell Survival

Trachootham

Ogasawara

et al. 2008

Antioxidants & Redox Signaling

1,529

1,177

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“…The ultrastructure of the myocardial cell was observed with a transmission electron microscope as described previously (14). For electron microscopic examination, following fixation in glutaraldehyde, the sample was refixed in 1% osmium tetroxide, embedded in epoxy resin, sectioned at 0.1-µm and double-stained with uranium acetate and lead citrate.…”

Section: Immunohistochemistry Analysis Of Membrane Cx43 In the Differmentioning

confidence: 99%

Ischemic postconditioning improves the expression of cellular membrane connexin 43 and attenuates the reperfusion injury in rat acute myocardial infarction

Zhao

et al. 2015

Biomedical Reports

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Abstract.To investigate the effects of cellular membrane connexin 43 (Cx43) and the potential details in ischemic postconditioning (IPOC)-induced cardioprotection, ischemia/reperfusion (IR) models were generated in 8-week-old male Sprague-Dawley rats by ligating the left coronary artery anterior descending branch. The serum levels of myocardial creatases, nitric oxide (NO) and malondialdehyde (MDA) levels, infarct size, arrhythmia events, expression and distribution of Cx43, ultrastructure and apoptosis in the myocardium in different treatments with IR, IR + IPOC, IR + diazoxide or IR + IPOC + 5-hydroxydecanoate acid (5-HD) were investigated. Consequently, IPOC decreased infarct size (10.9 vs. 43.3%, P<0.01) and the levels of myocardial creatases, NO and MDA, and improved the expression (16.8 vs. 25.2% and 6.4 vs. 32.8%, after 1-and 3-h reperfusion, respectively; P<0.01) and distribution of Cx43, ultrastructure and apoptosis (19.2 vs. 42.9%, P<0.01) significantly. Diazoxide partly simulated the effects, and 5-HD attenuated but not completely abolished the effects of IPOC. In addition, the phosphorylated Cx43 (p-Cx43) level in the IR + IPOC group was lower than that in the IR + diazoxide group after 1-h reperfusion (26.1 vs. 29.4%, P>0.05); however, it was reversed after 3-h reperfusion and the p-Cx43 level in the IR + IPOC group was significantly higher than that in the IR + diazoxide group (32.8 vs. 18.7%, P<0.01). In conclusion, cell membrane Cx43 is also involved in the process of IPOC-induced cardioprotection and the improvement of membrane Cx43 is more dependent on mitochondrial K ATP in the earlier phase of IPOC compared to the late phase of IPOC.

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“…This compound is most useful in mitigating the effects of ischemia and has found use in poststroke models. A few studies have shown the beneficial effects of ebselen in inhibiting endothelial dysfunction and vascular remodeling, but most have shown no bloodpressure effects (175,313). Ebselen is readily available commercially.…”

Section: Antioxidantsmentioning

confidence: 99%