Protective effect of antigen delivery using monoolein-based liposomes in experimental hematogenously disseminated candidiasis

Carneiro, Catarina; Correia, Alexandra; Lima, Tânia; Vilanova, Manuel; Pais, Célia; Gomes, Andreia C.; Oliveira, M. Elisabete; Sampaio, Paula

doi:10.1016/j.actbio.2016.05.001

Cited by 22 publications

(16 citation statements)

References 75 publications

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“…More recently, Carneiro et al ( 2015 , 2016 ) employed dimethyldioctadecylammonium bromide (DODAB) monoolein-based liposomes for delivery of C. albicans wall proteins. In the first study, prophylactic vaccination using the NPs in BALB/c mice stimulated humoral and cellular immune response with production of IgG antibodies against two specific proteins found in the cell wall, Cht3p and Xog1p.…”

Section: Current Scenario Of Nanotechnology In the Treatment And Vaccmentioning

confidence: 99%

Therapies and Vaccines Based on Nanoparticles for the Treatment of Systemic Fungal Infections

Kischkel

Rossi

Santos

et al. 2020

Front. Cell. Infect. Microbiol.

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Treatment modalities for systemic mycoses are still limited. Currently, the main antifungal therapeutics include polyenes, azoles, and echinocandins. However, even in the setting of appropriate administration of antifungals, mortality rates remain unacceptably high. Moreover, antifungal therapy is expensive, treatment periods can range from weeks to years, and toxicity is also a serious concern. In recent years, the increased number of immunocompromised individuals has contributed to the high global incidence of systemic fungal infections. Given the high morbidity and mortality rates, the complexity of treatment strategies, drug toxicity, and the worldwide burden of disease, there is a need for new and efficient therapeutic means to combat invasive mycoses. One promising avenue that is actively being pursued is nanotechnology, to develop new antifungal therapies and efficient vaccines, since it allows for a targeted delivery of drugs and antigens, which can reduce toxicity and treatment costs. The goal of this review is to discuss studies using nanoparticles to develop new therapeutic options, including vaccination methods, to combat systemic mycoses caused by Candida sp., Cryptococcus sp., Paracoccidioides sp., Histoplasma sp., Coccidioides sp., and Aspergillus sp., in addition to providing important information on the use of different types of nanoparticles, nanocarriers and their corresponding mechanisms of action.

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Section: Current Scenario Of Nanotechnology In the Treatment And Vaccmentioning

confidence: 99%

Therapies and Vaccines Based on Nanoparticles for the Treatment of Systemic Fungal Infections

Kischkel

Rossi

Santos

et al. 2020

Front. Cell. Infect. Microbiol.

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“…The combinations of DODAB and monoolein improved the fusion of the liposomes with cell membranes, thereby allowing their use for mammalian cell transfection [ 81 ] and in vitro gene silencing [ 82 ]. These combinations also induced strong humoral and cell-mediated immune responses, producing antibodies (IgGs) against specific cell wall proteins of Candida albicans (CWSP) useful for fighting fungus infections [ 77 , 83 ]. Figure 4 illustrates the use and activity of DODAB/monoolein vesicles as adjuvants as reproduced from reference [ 77 ].…”

Section: Assemblies From Cationic Lipids and Surfactantsmentioning

confidence: 99%

Cationic Nanostructures for Vaccines Design

Carmona-Ribeiro

Betancourt

2020

Biomimetics

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Subunit vaccines rely on adjuvants carrying one or a few molecular antigens from the pathogen in order to guarantee an improved immune response. However, to be effective, the vaccine formulation usually consists of several components: an antigen carrier, the antigen, a stimulator of cellular immunity such as a Toll-like Receptors (TLRs) ligand, and a stimulator of humoral response such as an inflammasome activator. Most antigens are negatively charged and combine well with oppositely charged adjuvants. This explains the paramount importance of studying a variety of cationic supramolecular assemblies aiming at the optimal activity in vivo associated with adjuvant simplicity, positive charge, nanometric size, and colloidal stability. In this review, we discuss the use of several antigen/adjuvant cationic combinations. The discussion involves antigen assembled to 1) cationic lipids, 2) cationic polymers, 3) cationic lipid/polymer nanostructures, and 4) cationic polymer/biocompatible polymer nanostructures. Some of these cationic assemblies revealed good yet poorly explored perspectives as general adjuvants for vaccine design.

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“…Recently, cationic liposomes studies incorporated cell wall surface proteins (CWSPs) of C. albicans and their immunostimulatory properties analyzed during subcutaneous administration [ 111 , 112 ]. Both studies employed DDA:monooleoylglycerol (MO) at 33:67 molar ratio.…”

Section: Liposomal-based Vaccines In Fungal Infection Treatmentmentioning

confidence: 99%

Liposomal vaccine formulations as prophylactic agents: design considerations for modern vaccines

Serrano

Burkhart

2017

J Nanobiotechnol

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Vaccinology is one of the most important cornerstones in modern medicine, providing better quality of life. The human immune system is composed of innate and adaptive immune processes that interplay when infection occurs. Innate immunity relies on pathogen-associated molecular patterns which are recognized by pathogen recognition receptors localized in antigen presenting cells. After antigen processing and presentation, CD4+ T cell polarization occurs, further leading to B cell and CD8+ activation and humoral and cell-mediated adaptive immune responses. Liposomes are being employed as vaccine technologies and their design is of importance to ensure proper immune responses. Physicochemical parameters like liposome size, charge, lamellarity and bilayer fluidity must be completely understood to ensure optimal vaccine stability and efficacy. Liposomal vaccines can be developed to target specific immune cell types for the induction of certain immune responses. In this review, we will present promising liposomal vaccine approaches for the treatment of important viral, bacterial, fungal and parasitic infections (including tuberculosis, TB). Cationic liposomes are the most studied liposome types due to their enhanced interaction with the negatively charged immune cells. Thus, a special section on the cationic lipid dimethyldioctadecylammonium and TB is also presented.

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Protective effect of antigen delivery using monoolein-based liposomes in experimental hematogenously disseminated candidiasis

Cited by 22 publications

References 75 publications

Therapies and Vaccines Based on Nanoparticles for the Treatment of Systemic Fungal Infections

Therapies and Vaccines Based on Nanoparticles for the Treatment of Systemic Fungal Infections

Cationic Nanostructures for Vaccines Design

Liposomal vaccine formulations as prophylactic agents: design considerations for modern vaccines

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