2016
DOI: 10.1016/j.actbio.2016.05.001
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Protective effect of antigen delivery using monoolein-based liposomes in experimental hematogenously disseminated candidiasis

Abstract: This work describes the immunomodulation capacity of the previously validated antigen delivery system (ADS) composed by dioctadecyldimethylammonium bromide (DODAB) and monoolein (MO) lipids incorporating the cell wall surface proteins (CWSP) from C. albicans. Here, we not only present the ability of this system in facilitating antigen uptake by DCs in vitro, but also that this system induces higher levels of pro-inflammatory cytokines and opsonizing specific IgG antibodies in serum of mice immunized subcutaneo… Show more

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Cited by 22 publications
(16 citation statements)
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References 75 publications
(99 reference statements)
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“…More recently, Carneiro et al ( 2015 , 2016 ) employed dimethyldioctadecylammonium bromide (DODAB) monoolein-based liposomes for delivery of C. albicans wall proteins. In the first study, prophylactic vaccination using the NPs in BALB/c mice stimulated humoral and cellular immune response with production of IgG antibodies against two specific proteins found in the cell wall, Cht3p and Xog1p.…”
Section: Current Scenario Of Nanotechnology In the Treatment And Vaccmentioning
confidence: 99%
“…More recently, Carneiro et al ( 2015 , 2016 ) employed dimethyldioctadecylammonium bromide (DODAB) monoolein-based liposomes for delivery of C. albicans wall proteins. In the first study, prophylactic vaccination using the NPs in BALB/c mice stimulated humoral and cellular immune response with production of IgG antibodies against two specific proteins found in the cell wall, Cht3p and Xog1p.…”
Section: Current Scenario Of Nanotechnology In the Treatment And Vaccmentioning
confidence: 99%
“…The combinations of DODAB and monoolein improved the fusion of the liposomes with cell membranes, thereby allowing their use for mammalian cell transfection [ 81 ] and in vitro gene silencing [ 82 ]. These combinations also induced strong humoral and cell-mediated immune responses, producing antibodies (IgGs) against specific cell wall proteins of Candida albicans (CWSP) useful for fighting fungus infections [ 77 , 83 ]. Figure 4 illustrates the use and activity of DODAB/monoolein vesicles as adjuvants as reproduced from reference [ 77 ].…”
Section: Assemblies From Cationic Lipids and Surfactantsmentioning
confidence: 99%
“…Recently, cationic liposomes studies incorporated cell wall surface proteins (CWSPs) of C. albicans and their immunostimulatory properties analyzed during subcutaneous administration [ 111 , 112 ]. Both studies employed DDA:monooleoylglycerol (MO) at 33:67 molar ratio.…”
Section: Liposomal-based Vaccines In Fungal Infection Treatmentmentioning
confidence: 99%