Protective effect of andrographolide against STZ induced Alzheimer’s disease in experimental rats: possible neuromodulation and Aβ(1–42) analysis

Patel, Royal; Kaur, Karamjeet; Singh, Shamsher

doi:10.1007/s10787-021-00843-6

Cited by 20 publications

(9 citation statements)

References 43 publications

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“…Many natural ingredients of TCM can not only restore hormone levels, but also have antiinflammatory and antioxidant features. This exactly corresponds precisely to the role TCM played in cutting off the vicious cycle in AD (17). Flavonoids are rich in many TCMs.…”

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confidence: 60%

Roles of traditional chinese medicine regulating neuroendocrinology on AD treatment

et al. 2022

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The incidence of sporadic Alzheimer’s disease (AD) is increasing in recent years. Studies have shown that in addition to some genetic abnormalities, the majority of AD patients has a history of long-term exposure to risk factors. Neuroendocrine related risk factors have been proved to be strongly associated with AD. Long-term hormone disorder can have a direct detrimental effect on the brain by producing an AD-like pathology and result in cognitive decline by impairing neuronal metabolism, plasticity and survival. Traditional Chinese Medicine(TCM) may regulate the complex process of endocrine disorders, and improve metabolic abnormalities, as well as the resulting neuroinflammation and oxidative damage through a variety of pathways. TCM has unique therapeutic advantages in treating early intervention of AD-related neuroendocrine disorders and preventing cognitive decline. This paper reviewed the relationship between neuroendocrine and AD as well as the related TCM treatment and its mechanism. The advantages of TCM intervention on endocrine disorders and some pending problems was also discussed, and new insights for TCM treatment of dementia in the future was provided.

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confidence: 60%

Roles of traditional chinese medicine regulating neuroendocrinology on AD treatment

et al. 2022

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“…Our study is the rst to report an improvement in short-term recognition memory by ANDRO in the ICV-STZ model of sAD. In a recent report, it was observed that ANDRO (15, 30, and 60 mg/kg, 14 days) protected rats against STZ-induced learning and memory impairment (Patel et al 2021). However, cognition was assessed 21 days after STZ infusion in the Morris Water Maze Test and in a modi ed version of the Elevated Plus Maze Test, which measures spatial longterm memory.…”

Section: Discussionmentioning

confidence: 97%

Andrographolide Attenuates Short-Term Spatial and Recognition Memory Impairment and Neuroinflammation Induced by a Streptozotocin Rat Model of Alzheimer’s Disease

et al. 2022

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Alzheimer's disease (AD) is a neurodegenerative disorder clinically manifested by a gradual cognitive decline. Intracerebroventricular injection (ICV) of streptozotocin (STZ), a model of Sporadic AD (sAD), shows many aspects of sAD abnormalities (i.e., neuroin ammation, oxidative stress, protein aggregation) resulting in memory impairment. Andrographolide (ANDRO), a natural diterpene lactone, has numerous bioactivities including anti-in ammatory and antioxidant properties. Studies in rodents revealed that ANDRO has neuroprotective properties and restores cognitive impairment. In the present study, we investigated the effects of ANDRO in the ICV-STZ model relative to short-term spatial memory (Object location test (OLT) and Y maze test), short-term recognition memory (Object recognition test (ORT)), locomotor activity (Open eld test (OFT)), expression of amyloid precursor protein (APP), and activation of astrocytes (glial brillary acidic protein (GFAP) expression) and microglia (ionized calcium-binding adapter molecule-1 (Iba-1) immunohistochemistry) in the prefrontal cortex (PFC) and hippocampus (HIP).Wistar rats were injected ICV with STZ (3 mg/kg) or vehicle and treated with ANDRO (2 mg/kg, i.p.; three times per week). After four weeks, ANDRO attenuated the impairments of the Y maze and ORT performances, and the increase of the astrocyte activation in the PFC induced by the ICV-STZ model. In addition, ANDRO decreased the number of activated microglia cells in the HIP of STZ-injected rats. The APP expression was not altered, neither by the STZ nor ANDRO. ANDRO showed a bene cial effect on memory impairment and neuroin ammation in the STZ model of AD.

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“…In contrast, the pathophysiology of the ICV-STZ animal model is similar to that of AD patients [ 47 ]. Furthermore, ICV-STZ has now been found to induce cognitive impairment and neuron damage [ 48 ], oxidative stress [ 49 ] and glucose/energy metabolism damage in the brain [ 50 ], insulin resistance in the brain [ 51 , 52 ], and finally lead to Tau hyperphosphorylation and Aβ deposition [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway

Huang

Chen

et al. 2022

Brain Sciences

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Alzheimer’s disease is the most common form of neurodegenerative disease, and increasing evidence shows that insulin signaling has crucial roles in AD initiation and progression. In this study, we explored the effect and underlying mechanism of SQW, a representative formula for tonifying the kidney and promoting yang, on improving the cognitive function in a streptozotocin-induced model of AD rats. We investigated memory impairment in the AD rats by using the Morris water test. HE and Nissl staining were employed to observe the histomorphological changes in the hippocampal. Expression levels of NeuN and proteins related to Tau and apoptosis were measured using immunohistochemistry and Western blotting, respectively. Additionally, we performed RNA sequencing, and the selected hub genes were then validated by qRT-PCR. Furthermore, the protein expression levels of PI3K/AKT pathway-related proteins were detected by Western blot. We found that SQW treatment significantly alleviated learning and memory impairment, pathological damage, and apoptosis in rats, as evidenced by an increased level of NeuN and Bcl-2, and decreased phosphorylation of Tau, Bax, and Caspase-3 protein expression. SQW treatment reversed the expression of insulin resistance-related genes (Nr4a1, Lpar1, Bdnf, Atf2, and Ppp2r2b) and reduced the inhibition of the PI3K/AKT pathway. Our results demonstrate that SQW could contribute to neuroprotection against learning and memory impairment in rats induced by STZ through activation of the PI3K/AKT pathway.

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Protective effect of andrographolide against STZ induced Alzheimer’s disease in experimental rats: possible neuromodulation and Aβ(1–42) analysis

Cited by 20 publications

References 43 publications

Roles of traditional chinese medicine regulating neuroendocrinology on AD treatment

Roles of traditional chinese medicine regulating neuroendocrinology on AD treatment

Andrographolide Attenuates Short-Term Spatial and Recognition Memory Impairment and Neuroinflammation Induced by a Streptozotocin Rat Model of Alzheimer’s Disease

Shen Qi Wan Ameliorates Learning and Memory Impairment Induced by STZ in AD Rats through PI3K/AKT Pathway

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