Protective Effect of <i>Gingo biloba</i> Extract on Carbendazim-Induced Hepatotoxicity in Albino Rats

Abstract

Carbendazim is a broad spectrum carbamate fungicide used in the control of various fungal pathogens. The present work studied the effect of carbendazim on the liver of albino rats and the possible protective role of Ginko biloba extract (EGB). Liver of carbendazim-treated animals showed histopathological and histochemical alterations. The histopathological changes include hepatic tissue impairment, cytoplasmic vacuolization of the hepatocytes, and congestion of blood vessels, leucocytic infiltrations and fatty infiltration. Histochemical results showed reduction of carbohydrates and total proteins in hepatic tissues. Moreover, liver function enzymes (ALT, AST) were elevated in sera of carbendazim-treated animals. Coadministration of EGB with Carbendazim improved the hisological and histochemical changes observed in animals treated with carbendazim. In addition, EGB treatment leads to a significant decrease in ALT and AST. According to the present results, it is concluded that EGB can improve the hepatotoxicity of carbendazim and this effect may be attributed to antioxidant properties of Ginko biloba extract.

Mitigating potential ofGinkgo bilobaextract and melatonin against hepatic and nephrotoxicity induced by Bisphenol A in male rats

“…Also, it induced degeneration of proximal tubules' epithelial cells [60,61]. In the present study, co-administration of GBE and/or Mel in combination with BPA revealed remarkable improvement in the liver and kidney tissues compared to BPA-treated group [62]. They demonstrated that the histopathological score of fibrosis together with liver function were improved in rats treated with CCl 4 plus GBE.…”

Alleviation of carbendazim toxicity effect by Moringa oleifera oil and Linum usitatissimum L. oil on testes of male rats: Physiological, histological and in silico study

“…Various plants and their oils have been previously used to treat the toxicity of CBZ on animals, such as olive ( Olea europaea) leaves Zari and Al-Attar, (2011) , licorice ( Glycyrrhiza glabra ), Fenugreek ( Trigonella foenum-graecum Linn .) seeds extract Lamfon (2012) , Gingo bilola extract Mahboub and Lamfon, (2013) , Ginger ( Zingiber officinale ) Salihu et al (2016) , Jaft internal layer of Quercus brantii Mirzaei et al (2015) , Nigella sativa oil Hashem et al (2018) , Quercetin Abou Zaid et al (2018) , Nigella sativa and Foeniculum vulgar seeds extracts Alghamdi, (2020) , Vitamin C ( Lalhriatpuia et al, 2021 , Kiran, 2022 ), and banana peel ( Abdel-Rahman et al, 2022 ).…”

Protective Effects of Ginkgo biloba on Acrylamide -Induced Rats Hepatotoxicity

“…Chemicals: Acrylamide (ACR) from Sigma Chemical Company was made just before usage by dissolving it in distilled water [9] . It was purchased by Amriya Company (Egypt) for Pharmaceutical Industries under license from Beaufour Ipsen International, Paris, France [10] . GB extract was used as Tanakan 761 (EGB).…”