Protective Effect of Alcoholic Extract of Garden Cress Seeds on the Histopathological Changes of the Ventral Prostate in Streptozotocin Diabetic Rats

Abstract

KAMANI, M.; MHABADI, J. A.; ATLASI, M. A.; SEYEDI, F.; KAMANI, E. & NIKZAD, H.Protective effect of alcoholic extract of garden cress seeds on the histopathological changes of the ventral prostate in streptozotocin diabetic rats. Int. J. Morphol., 35(3):1178Morphol., 35(3): -1184Morphol., 35(3): , 2017. SUMMARY:Diabetes mellitus is a common serious metabolic illness occurring worldwide that may lead to male infertility. Various plants have been used in the treatment of diabetes. In this study, the effect of garden cress (Lepidium sativum) seed extract on fasting blood sugar is assessed for its protective effect on histopathological changes in the ventral prostate gland of streptozotocine-induced diabetic rats. Fifty adult male Wistar rats were randomly selected into five groups. Group 1 was the control placebo group where rats received only 0.1 mL normal saline via gastric gavages. Rats in Group 2 received an intraperitoneal injection of STZ 60 mg/kg body weight and those with FBS >250 mg/dL were considered diabetic. In Group 3, diabetic rats received insulin (3 U/100 g body weight) while in Groups 4 and 5 diabetic rats received 0.1 ml of 200 and 400 mg/kg respectively of an ethanol extract of Lepidium sativum seeds by gavage daily. The prostate was removed and weighed before transfer to Bouin's solution for histological studies. Administration of the 200 and 400 mg/kg doses of Lepidium sativum seed extract increased epithelium height and decreased interstitial volume density and fibromuscular thickness of the prostate significantly. Also, the volume density of the epithelium, fibro muscular, lumen, and interstitial tissues were changed significantly. The results suggest that Lepidium sativum seed extract has beneficial effects as a protective agent against the detrimental effects of diabetes on the reproductive system of diabetic male rats.

The potential protective role of flaxseed extract on ventral prostate in a rat model of streptozotocin-induced diabetes: A histological and immunohistochemical study

“…Administration of flaxseed extract to diabetic rats protected the prostate tissue and partially prevented most of the epithelial and stromal changes appearing more or less as control group. These results coincided with previous studies indicating that Streptozotocin-induced DM suppressed the reproductive activity due to hyperglycaemia-induced oxidative stress and structural alterations in the testes [3,5,27] . Moreover, other study reported that the prostate structural changes observed in diabetic animals were identical to those observed in castrated animals [28] .…”

The Potential Therapeutic Role of Ginkgo Biloba Extracts on the Prostate in a Rat Model of Streptozotocin-Induced Diabetes: A Histomorphometric Study

“…Cells had irregular nuclei. These results synchronized with previous studies which indicating that Streptozotocin-induced DM suppressed the reproductive activity due to structural alterations in the testes and hyperglycemiainduced oxidative stress (19)(20)(21)(22)(23).…”

Assessment of the Protective Effect ofLepidium sativumagainst Aluminum-Induced Liver and Kidney Effects in Albino Rat

“…This hypolipidemic effect of LS might be attributed to its possible inhibitory effect on the endogenous synthesis of lipids. In a more recent study, both hypoglycemic and hypolipidemic effects of LS seeds extract administrated at a dose of 20 mg/k were reported by Kamani et al and they attributed these effects to the antioxidant activity of LS [29].…”