Protective effect of adenosine triphosphate against sunitinib-related skin damage in rats

Abstract

Cutaneous side effects associated with sunitinib use are a major problem in patients receiving cancer treatment. The aim of this study was to investigate the protective effect of adenosine triphosphate (ATP) against possible skin damage resulting from sunitinib use in rats. Thirty Albino Winstar rats were divided into the following three groups: healthy controls (HCs, n = 10), sunitinib (SUN, n = 10), and sunitinib + ATP (SAT, n = 10). ATP was injected intraperitoneally at a dose of 2 mg/kg. One hour subsequent to the administration of ATP and 0.9% NaCl, the SAT and SUN groups were orally administered a dose of 25 mg/kg sunitinib to the stomach. Macroscopic evaluation of the skin indicated lower levels of skin damage in the SAT group than in the SUN group. As an indicator of oxidative stress, malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) levels were significantly higher in the SUN group than in the HC group, while total glutathione (tGSH) and total antioxidant status (TAS) levels were significantly lower. However, MDA, TOS, and OSI levels were significantly lower in the SAT group than in the SUN group, while tGSH and TAS levels were significantly higher. Histopathological examination revealed keratin plugs with edema, vasopathology, and inflammatory cell infiltration in the SUN group. The SAT group showed less necrotic epithelium, keratin plugs, edema, and vasopathology than the SUN group. ATP can be effective in preventing skin damage caused by sunitinib use by reducing oxidative stress.

Effect of adenosine triphosphate, benidipine and their combinations on bevacizumab-induced kidney damage in rats

“…11 A recent study by Yıldırım et al also reports that ATP heals oxidative dermal damage induced by sunitinib, a target-driven anticancer drug. 27 It has also been found that VEGF inhibition is accountable for the oxidative heart and dermal damage associated with tyrosine kinase inhibitors (target-driven anticancer drugs), and that this damage was minimized by the administration of ATP. 28,29 The current biochemical and histopathological results show that the oxidative renal damage associated with bevacizumab is also suppressed by benidipine.…”

P2X7 receptor antagonist improves gastrointestinal disorders in spontaneously hypertensive rats

“…In SHR groups, the feed was removed, and, after 5-min, the groups were treated with BBG (50 mg/kg, sc ), a P2X7 antagonist ( 14 ). Thirty minutes after BBG, 2 separate groups received ANG II (100 μg/kg, ip ) ( 15 ) or ATP (2 mg/kg, ip ) ( 16 ). Ninety minutes after the treatments, the rats were sacrificed by an overdose of sodium thiopental (100 mg/kg, ip ).…”

Molecular mechanism of the protective effect of adenosine triphosphate against paracetamol-induced liver toxicity in rats

“…One possible mechanism could be the activation of A1 and A3 adenosine receptors, which play a role in triggering a cardioprotective effect against ischemia-reperfusion injury, a phenomenon known as ischemic preconditioning (Kudo et al 2002;Hochhauser et al 2007). A recent study reported that ATP protects oral mucosal tissues from oxidative damage by preventing an increase in malondialdehyde (MDA) and decreasing the amount of total glutathione (tGSH) (Yıldırım et al 2020). This also suggests that ATP may help treat the hepatotoxicity of paracetamol.…”