Protective Effect of a Lignan-enriched Extract ofFructus schisandraeon Physical Exercise Induced Muscle Damage in Rats

Ko, Kam Ming; Mak, Duncan H.; Li, Pui Chun; Poon, Michel Kwong Tat; Ip, Siu‐Po

doi:10.1002/(sici)1099-1573(199608)10:5<450::aid-ptr872>3.0.co;2-p

Cited by 7 publications

(2 citation statements)

References 4 publications

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“…Whereas the ex vivo antioxidant activity produced by Chinese tonifying herbs, as assessed by measuring the extent of the enhancement of hepatic GRC, may reflect their beneficial effect on hepatic glutathione antioxidant status in vivo. Previous studies from our laboratory have demonstrated that the enhancement of glutathione antioxidant system could protect against oxidative damage induced in hepatic, myocardial as well as skeletal muscle tissues in rodents (Ko et al, 1995b(Ko et al, , 1996Yim et al, 1998). The hepatic GRC promoting action produced by Chinese tonifying herbs may represent a generalized in vivo antioxidant action that can counteract the increased formation of free radicals, as in the case of agingrelated disorders.…”

Section: Discussionmentioning

confidence: 94%

Antioxidant and Immunomodulatory Activities of Chinese Tonifying Herbs

Yim

2002

Pharmaceutical Biology

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In an effort to investigate the pharmacological basis for the health promoting actions of Chinese tonifying herbs in four main categories (Qi-invigorating, blood-enriching, Yinnourishing and Yang-promoting), antioxidant and immunomodulatory activities of the methanol extracts prepared from 36 tonifying herbs were examined by both in vitro and ex vivo assay systems. The results indicated that the tested herbs showed in vitro (~40%) and ex vivo (~30%) antioxidant activities. Among the herbs, almost 60% of the Yangpromoting herbs showed in vitro antioxidant activity. The overall correlation between in vitro and ex vivo antioxidant activities was poor, except for the Yang-promoting herbs. In regard to immunomodulatory activity, the Qi-invigorating herbs (60%) and Yin-nourishing herbs (75%) showed in vitro immunostimulatory activity, whereas 56% of the Yangpromoting herbs showed in vitro immunosuppressive activity. About half (44%) of all tested herbs showed ex vivo immunostimulatory activity and 6% showed ex vivo immunosuppressive activity. The overall correlation between in vitro and ex vivo immunostimulatory activities was apparent, particularly for the Yin-nourishing and Yang-promoting herbs. The measurement of antioxidant and immunomodulatory activities may serve as a means for functionally relevant quality assessment of Chinese herbs and their related health products.

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Section: Discussionmentioning

confidence: 94%

Antioxidant and Immunomodulatory Activities of Chinese Tonifying Herbs

Yim

2002

Pharmaceutical Biology

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“…As the main active components of Fructus Schisandrae, lignans have been shown in various studies to have diverse effects, such as pretreatment on physical exercise-induced muscle damage [27], anti-proliferative effects on tumor cells [28], [29] and anti-hepatitis B virus (HBV) activity in vitro [30]. This is in addition to their well-studied influence on the liver [31]–[33].…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Deoxyschizandrin and Schisantherin A against Myocardial Ischemia–Reperfusion Injury in Rats

Chang

Yang

et al. 2013

PLoS ONE

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BackgroundOur previous studies suggested that deoxyschizandrin (DSD) and schisantherin A (STA) may have cardioprotective effects, but information in this regard is lacking. Therefore, we explored the protective role of DSD and STA in myocardial ischemia–reperfusion (I/R) injury.Methodology/Principal FindingsAnesthetized male rats were treated once with DSD and STA (each 40 µmol/kg) through the tail vein after 45 min of ischemia, followed by 2-h reperfusion. Cardiac function, infarct size, biochemical markers, histopathology and apoptosis were measured and mRNA expression of gp91phox in myocardial tissue assessed by RT-PCR. Neonatal rat cardiomyocytes were pretreated with DSD and STA and then damaged by H2O2. Cell apoptosis was tested by a flow cytometric assay. Compared with the I/R group: (i) DSD and STA could significantly reduce the abnormalities of LVSP, LVEDP, ±dp/dtmax and arrhythmias, thereby showing their protective roles in cardiac function; (ii) DSD and STA could significantly attenuate the infarct size and MDA release while increasing SOD activity, suggesting a role in reducing myocardial injury; (iii) tissue morphology and myocardial textual analysis revealed that DSD and STA mitigated changes in myocardial histopathology; (iv) DSD and STA decreased apoptosis (33.56±2.58% to 10.28±2.80% and 10.98±1.99%, respectively) and caspase-3 activity in the myocardium (0.62±0.02 OD/mg to 0.38±0.02 OD/mg and 0.32±0.02 OD/mg, respectively), showing their protective effects upon cardiomyocytes; and (v) DSD and STA had similar protective effects on I/R injury as those seen with the positive control metoprolol. In vitro, DSD and STA could significantly decrease the apoptosis of neonatal cardiomyocytes.Conclusions/SignificanceThese data suggest that DSD and STA can protect against myocardial I/R injury. The underlining mechanism may be related to their role in inhibiting cardiomyocyte apoptosis.

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Novel antioxidant activities in shengmai san"Equation missing" used for treatment of coronary heart diseaseused for treatment of coronary heart disease

Che

1997

CJIM

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Protective Effect of a Lignan-enriched Extract ofFructus schisandraeon Physical Exercise Induced Muscle Damage in Rats

Cited by 7 publications

References 4 publications

Antioxidant and Immunomodulatory Activities of Chinese Tonifying Herbs

Antioxidant and Immunomodulatory Activities of Chinese Tonifying Herbs

Protective Role of Deoxyschizandrin and Schisantherin A against Myocardial Ischemia–Reperfusion Injury in Rats

Novel antioxidant activities in shengmai san"Equation missing" used for treatment of coronary heart diseaseused for treatment of coronary heart disease

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