Protective effect of ((4-<i>tert</i>-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide, a novel unsymmetrical divinyl sulfide, on an oxidative stress model induced by sodium nitroprusside in mouse brain: involvement of glutathione peroxidase activity

Ianiski, Francine R.; Alves, Catiane B.; Bassaco, Mariana M.; Silveira, Cláudio C.; Luchese, Cristiane

doi:10.1111/jphp.12300

Cited by 10 publications

(1 citation statement)

References 60 publications

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“…Functionalized divinyl sulfides and (4-tert-butylcyclohexylidene)methyl styryl sulfides, show antioxidant, antinociceptive, and glutathione peroxidase-like properties (Figure 1) [43,44]. The potential of vinyl sulfides with respect to biological activity can be demonstrated by the example of a cyclic peptide with the vinyl sulfide group (Figure 1), which is an angiotensin II analog, exhibiting high affinity and agonist activity at the AT1 receptor [45].…”

Section: Introductionmentioning

confidence: 99%

Efficient Regioselective Synthesis of Novel Ensembles of Organylselanyl-Functionalized Divinyl Sulfides and 1,3-Thiaselenoles under Phase Transfer Catalysis Conditions

Filippov,

Amosova,

Makhaeva

et al. 2023

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Efficient regioselective synthesis of novel ensembles of organylselanyl-functionalized 1,3-thiaselenoles and divinyl sulfides in high yields under phase transfer catalysis conditions was developed. The methodology is based on the generation of sodium [(Z)-2-(vinylsulfanyl)ethenyl]selenolate and 1,3-thiaselenol-2-ylmethylselenolate, which were involved in a nucleophilic addition reaction with activated alkenes such as acrylonitrile, acrylamide, methyl vinyl ketone, methyl, and ethyl acrylates. In the case of methyl vinyl ketone, the reaction was accompanied by the hydrogenation of the carbonyl group. Methylene chloride was involved in the nucleophilic substitution reaction with sodium [(Z)-2-(vinylsulfanyl)ethenyl]selenolate and 1,3-thiaselenol-2-ylmethylselenolate to afford new polyunsaturated compounds with several sulfur and selenium atoms.

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Section: Introductionmentioning

confidence: 99%

Efficient Regioselective Synthesis of Novel Ensembles of Organylselanyl-Functionalized Divinyl Sulfides and 1,3-Thiaselenoles under Phase Transfer Catalysis Conditions

Filippov,

Amosova,

Makhaeva

et al. 2023

Catalysts

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A Convenient Wittig‐Horner Mediated Synthesis of 3‐Vinylsulfide Derivatives of Indoles

et al. 2022

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A simple and robust coupling protocol is reported to provide the previously unknown indole derivatives carrying vinylsulfide motifs attached to C−3 of the heterocycle. The developed strategy involved a Wittig‐Horner reaction with different phosphinoxide derivatives. The reaction conditions were optimized and its scope and limitations were assessed. The target compounds, including 3‐arylvinylsulfides as well as symmetric and dissymmetric bis‐vinylsulfides, were obtained in a straightforward way, as mixtures of geometric isomers, in good to excellent yields.

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Antinociceptive property of vinyl sulfides in spite of their weak antioxidant activity

et al. 2017

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Protective effect of ((4-tert-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide, a novel unsymmetrical divinyl sulfide, on an oxidative stress model induced by sodium nitroprusside in mouse brain: involvement of glutathione peroxidase activity

Abstract: In conclusion, ((4-tert-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide protected against oxidative damage caused by SNP in mouse brain. GPx activity is involved, at least in part, in the cerebral antioxidant action of this compound.

Cited by 10 publications

References 60 publications

Efficient Regioselective Synthesis of Novel Ensembles of Organylselanyl-Functionalized Divinyl Sulfides and 1,3-Thiaselenoles under Phase Transfer Catalysis Conditions

Efficient Regioselective Synthesis of Novel Ensembles of Organylselanyl-Functionalized Divinyl Sulfides and 1,3-Thiaselenoles under Phase Transfer Catalysis Conditions

A Convenient Wittig‐Horner Mediated Synthesis of 3‐Vinylsulfide Derivatives of Indoles

Antinociceptive property of vinyl sulfides in spite of their weak antioxidant activity

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