Protective effect and mechanism of <i>Lycium ruthenicum</i> polyphenols against acrylamide-induced neurotoxicity

Pang, Yu-Fei; Chen, Jingxin; Yang, Jianjun; Xue, Yanzhong; Gao, Hua; Gao, Qing‐Han

doi:10.1039/d3fo00623a

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…LR extract (LRE) decreased the contents of lipid peroxidation and malondialdehyde (MDA) in serum and brain, accompanied by increased activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX), in D-galactose induced aging mice ( Cui et al, 2023 ). Polyphenols in LRE had neuroprotective effects against acrylamide-induced neurotoxicity ( Pang et al, 2023 ). Polysaccharides in LRE protected cortical neurons against oxygen-glucose deprivation/reperfusion in neonatal hypoxic-ischemic encephalopathy ( Deng et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Lycium ruthenicum water extract preserves retinal ganglion cells in chronic ocular hypertension mouse models

Liu,

Zhou,

et al. 2024

Front. Pharmacol.

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Lycium ruthenicum Murray (LR), known as “black goji berry” or “black wolfberry”, is widely utilized in chinese herbal medicine. LR fruit showed its antioxidant and/or anti-inflammation activity in treating cardiac injury, experimental colitis, nonalcoholic fatty liver disease, fatigue, and aging. Glaucoma is the leading cause of irreversible blindness. Besides elevated intraocular pressure (IOP), oxidative stress and neuroinflammation were recognized to contribute to the pathogenesis of glaucoma. This study investigated the treatment effects of LR water extract (LRE) on retinal ganglion cells (RGCs) threatened by sustained IOP elevation in a laser-induced chronic ocular hypertension (COH) mouse model and the DBA/2J mouse strain. The antioxidation and anti-inflammation effects of LRE were further tested in the H2O2-challenged immortalized microglial (IMG) cell line in vitro. LRE oral feeding (2 g/kg) preserved the function of RGCs and promoted their survival in both models mimicking glaucoma. LRE decreased 8-hydroxyguanosine (oxidative stress marker) expression in the retina. LRE reduced the number of Iba-1+ microglia in the retina of COH mice, but not in the DBA/2J mice. At the mRNA level, LRE reversed the COH induced HO-1 and SOD-2 overexpressions in the retina of COH mice. Further in vitro study demonstrated that LRE pretreatment to IMG cells could significantly reduce H2O2 induced oxidative stress through upregulation of GPX-4, Prdx-5, HO-1, and SOD-2. Our work demonstrated that daily oral intake of LRE can be used as a preventative/treatment agent to protect RGCs under high IOP stress probably through reducing oxidative stress and inhibiting microglial activation in the retina.

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Section: Introductionmentioning

confidence: 99%

Lycium ruthenicum water extract preserves retinal ganglion cells in chronic ocular hypertension mouse models

Liu,

Zhou,

et al. 2024

Front. Pharmacol.

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Electrospun Pullulan/Hemp Protein Nanohybrids for Sustained Release of Phenylethanoid Glycosides

Jarić,

Petrović,

Jurašin

et al. 2024

Food Bioprocess Technol

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Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus

Wang,

He,

et al. 2024

Phytomedicine

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Protective effect and mechanism of Lycium ruthenicum polyphenols against acrylamide-induced neurotoxicity

Abstract: This study aimed to investigate the potential neuroprotective effects of Lycium ruthenicum polyphenols (LRP) against acrylamide (ACR)-induced neurotoxicity and the mechanism of action in vitro and in vivo. LRP treatment...

Cited by 3 publications

References 61 publications

Lycium ruthenicum water extract preserves retinal ganglion cells in chronic ocular hypertension mouse models

Lycium ruthenicum water extract preserves retinal ganglion cells in chronic ocular hypertension mouse models

Electrospun Pullulan/Hemp Protein Nanohybrids for Sustained Release of Phenylethanoid Glycosides

Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus

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