Protective effect against focal cerebral ischemia injury in acute phase of a novel invasive device for regional hypothermia

Chang, Ya-Pei; Liao, Pen-Ting; Shen, Ein‐Yiao; Liu, I-Hsuan

doi:10.1016/j.jcma.2014.07.009

Cited by 2 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These protective mechanisms have been covered in less detail in LH studies compared to those using systemic TH, but encouraging initial evidence suggests that these targets are similarly affected by LH application after stroke. So far, neuroprotective mechanisms validated by both LH and systemic TH stroke studies include modulation of immune function and activity (Kurisu et al, 2016; Liu et al, 2016, 2018), cell death processes (Chang et al, 2015; Liu et al, 2016; Sun et al, 2015; Wu et al, 2017), BBB permeability (Sun et al, 2013, 2015), edema (Gao et al, 2015; Kurisu et al, 2016; Zhao et al, 2013), as well as up‐regulation of cell survival pathways and neurogenesis (Corey et al, 2019).…”

Section: Focal Versus Systemic Th Treatment: a Brief Mechanistic Comparisonmentioning

confidence: 99%

Targeting focal ischemic and hemorrhagic stroke neuroprotection: Current prospects for local hypothermia

Liddle

Kalisvaart

Abrahart

et al. 2021

Journal of Neurochemistry

View full text Add to dashboard Cite

Therapeutic hypothermia (TH) has applications dating back millennia. In modern history, however, TH saw its importation into medical practice where investigations have demonstrated that TH is efficacious in ischemic insults, notably cardiac arrest and hypoxic‐ischemic encephalopathy. As well, studies have been undertaken to investigate whether TH can provide benefit in focal stroke (i.e., focal ischemia and intracerebral hemorrhage). However, clinical studies have encountered various challenges with induction and maintenance of post‐stroke TH. Most clinical studies have attempted to use body‐wide cooling protocols, commonly hindered by side effects that can worsen post‐stroke outcomes. Some of the complications and difficulties with systemic TH can be circumvented by using local hypothermia (LH) methods. Additional advantages include the potential for lower target temperatures to be achieved and faster TH induction rates with LH. This systematic review summarizes the body of clinical and preclinical LH focal stroke studies and raises key points to consider for future LH research. We conclude with an overview of LH neuroprotective mechanisms and a comparison of LH mechanisms with those observed with systemic TH. Overall, whereas many LH studies have been conducted preclinically in the context of focal ischemia, insufficient work has been done in intracerebral hemorrhage. Furthermore, key translational studies have yet to be done in either stroke subtype (e.g., varied models and time‐to‐treat, studies considering aged animals or animals with co‐morbidities). Few clinical LH investigations have been performed and the optimal LH parameters to achieve neuroprotection are unknown.

show abstract

Section: Focal Versus Systemic Th Treatment: a Brief Mechanistic Comparisonmentioning

confidence: 99%

Targeting focal ischemic and hemorrhagic stroke neuroprotection: Current prospects for local hypothermia

Liddle

Kalisvaart

Abrahart

et al. 2021

Journal of Neurochemistry

View full text Add to dashboard Cite

show abstract

“…lower than that in the control group, which indicated a certain inhibitory effect of mild hypothermia on brain inflammation. At the same time, associated animal experiments indicated that local hypothermia treatment may reduce the area of cerebral infarction(27,28). With the continuous improvement of scientific research, an increasing number of studies…”

mentioning

confidence: 99%

Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL‑1β, IL‑6, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and clinical significance

Zhao

et al. 2022

Exp Ther Med

View full text Add to dashboard Cite

The present study aimed to explore the effects and clinical importance of serum interleukin (IL) IL-1β, IL-6, C-reactive protein (CRP), intercellular adhesion molecule (ICAM)-1 and matrix metalloproteinase (MMP)-2 in patients with acute cerebral infarction undergoing intravenous thrombolysis during simultaneous hypothermia therapy. A total of 80 patients with acute cerebral infarction who were treated at our hospital were randomly selected. They were divided into groups A and B. The two groups were treated with intravenous thrombolysis, while group B received sub-hypothermia treatment. Prior to treatment and at 7 days after treatment, 5 ml of venous blood was collected and stored in a freezer at -80˚C. IL-1β, IL-6, CRP, ICAM-1 and MMP-2 levels were detected by ELISA and compared between the groups and time-points. The results were as follows: i) At 7 days after treatment, the levels of IL-1β, IL-6, CRP, ICAM-1 and MMP-2 in group B were significantly decreased compared with those in group A (P<0.05), while there was no significant difference of these levels between group A and B before treatment (P>0.05). The incidence of adverse reactions in group A and group B was 35 and 20% respectively, and the mortality rate was 10 and 5%, respectively. There were no significant differences in adverse events and mortality between the two groups (P>0.05). In addition, a positive correlation of the level of IL-1β, IL-6, CRP, ICAM-1 and MMP-2 with the National Institutes of Health Stroke Scale score was determined in the patients prior to treatment. In conclusion, mild hypothermia treatment in addition to intravenous thrombolysis significantly reduced the levels of IL-1β, IL-6, CRP, ICAM-1 and MMP-2 in patients with acute cerebral infarction and reduced inflammation, and should therefore be incorporated in clinical practice.

show abstract

Protective effect against focal cerebral ischemia injury in acute phase of a novel invasive device for regional hypothermia

Abstract: Our findings indicated that the device can effectively achieve regional hypothermia and could be beneficial for patients with cerebral ischemia during the acute phase.

Cited by 2 publications

References 48 publications

Targeting focal ischemic and hemorrhagic stroke neuroprotection: Current prospects for local hypothermia

Targeting focal ischemic and hemorrhagic stroke neuroprotection: Current prospects for local hypothermia

Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL‑1β, IL‑6, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and clinical significance

Contact Info

Product

Resources

About