Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms

Ahmadi, Ali; Mortazavi, Zoha; Mehri, Soghra; Rahbardar, Mahboobeh Ghasemzadeh

doi:10.1007/s40199-022-00443-x

Cited by 6 publications

(3 citation statements)

References 125 publications

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“…It mainly contains flavonoids, glycosides, terpenoids, volatile oils, and other components. It has many protective effects for the body, especially for the digestive system, cardiovascular system, and nervous system, among others (Ahmadi et al, 2022). Baicalin is the main and important active component of scutellarin.…”

Section: Discussionmentioning

confidence: 99%

Baicalin Inhibits VSMC Phenotypic Transition and Ameliorates Atherosclerosis via GSK3β-TCF21 Signaling Pathway

Huo,

Lin,

et al. 2024

Pharmacognosy Magazine

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Background: Atherosclerosis (AS) is the pathological basis of acute myocardial infarction, acute stroke, and other acute critical illnesses. Vascular smooth muscle cell (VSMC) phenotypic transformation plays a remarkable role in the occurrence and development of AS. Previous studies have found that GSK3β-TCF21 is a key signaling pathway regulating VSMC phenotypic transformation. Baicalin is an important herbal monomer for cardiovascular protection, but whether it can regulate the GSK3β-TCF21 signaling pathway and VSMC phenotypic transformation remains unclear. Purpose: The study aimed to explore the role of Baicalin in AS and VSMC phenotypic transformation and whether the GSK3β-TCF21 signaling pathway participates in this process. Materials and Methods: In this study, through the AS mouse model and ox-LDL-induced VSMC phenotypic transformation model in vitro, the effect of Baicalin on the GSK3β-TCF21 signaling pathway and VSMC phenotypic transformation was investigated. Results: Pathological staining showed that the AS plaque area of the Baicalin group decreased significantly ( p < .001). The expression of the marker gene (TAGLN, ACTA2, CNN1, and MYH11) of VSMC phenotypic transformation was significantly increased ( p < .001) after Baicalin treatment. Baicalin could activate GSK3β and increase the expression of TCF21 significantly ( p < .001) to inhibit VSMC phenotypic transition. Inhibiting the GSK3β-TCF21 signaling pathway was able to reduce the effects of Baicalin on reducing VSMC phenotypic transition and protecting AS. Conclusion: Our study indicates that Baicalin is protective in inhibiting VSMC phenotypic transformation and ameliorating AS by regulating GSK3β-TCF21.

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Section: Discussionmentioning

confidence: 99%

Baicalin Inhibits VSMC Phenotypic Transition and Ameliorates Atherosclerosis via GSK3β-TCF21 Signaling Pathway

Huo,

Lin,

et al. 2024

Pharmacognosy Magazine

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“…Different studies demonstrated that baicalin, baicalein, and SB could act as potential antidotes or protective agents against the damage induced by natural toxins and physical factors through the alleviation of oxidative stress and inflammation [78]. The authors of the review presented the molecular mechanisms of their antitoxic effects and concluded that cytoprotective properties of baicalin and baicalein in vivo and in vitro are the most potent when they are introduced into the culture medium or animal prior to toxic compounds.…”

Section: Protective Agentmentioning

confidence: 99%

“…factors through the alleviation of oxidative stress and inflammation [78]. The authors of the review presented the molecular mechanisms of their antitoxic effects and concluded that cytoprotective properties of baicalin and baicalein in vivo and in vitro are the most potent when they are introduced into the culture medium or animal prior to toxic compounds.…”

Section: Protective Agentmentioning

confidence: 99%

Baicalin—Current Trends in Detection Methods and Health-Promoting Properties

et al. 2023

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Baicalin (7-D-glucuronic acid-5,6-dihydroxyflavone) belongs to natural flavonoids extracted from the roots of Scutellaria baicalensis, the plant used in traditional Chinese medicine. It has been proven that baicalin has various pharmacological activities, such as antioxidant, anti-inflammatory, anticancer, antibacterial, and anti-apoptotic ones. However, it is essential not only to determine the medical usefulness of baicalin, but also to find and develop the most effective methods for its extraction and detection. Therefore, the aim of this review was to summarize the current methods of detection and identification of baicalin and to present the medical applications of baicalin and the underlying mechanisms of its action. Based on the review of the latest literature, it can be concluded that liquid chromatography alone or together with mass spectrometry is the most commonly used method for the determination of baicalin. Recently, also new electrochemical methods have been established, e.g., biosensors with fluorescence, which have better detection limits, sensitivity, and selectivity.

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Designing green and recyclable switchable supramolecular deep eutectic solvents for efficient extraction of flavonoids from Scutellariae Radix and mechanism exploration

Zhang,

Li,

Hai

et al. 2024

Journal of Chromatography A

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Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms

Cited by 6 publications

References 125 publications

Baicalin Inhibits VSMC Phenotypic Transition and Ameliorates Atherosclerosis via GSK3β-TCF21 Signaling Pathway

Baicalin Inhibits VSMC Phenotypic Transition and Ameliorates Atherosclerosis via GSK3β-TCF21 Signaling Pathway

Baicalin—Current Trends in Detection Methods and Health-Promoting Properties

Designing green and recyclable switchable supramolecular deep eutectic solvents for efficient extraction of flavonoids from Scutellariae Radix and mechanism exploration

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