Protective and pro-inflammatory roles of intestinal bacteria

Webb, Cynthia Reinoso; Koboziev, Iurii; Furr, Kathryn L.; Grisham, Matthew B.

doi:10.1016/j.pathophys.2016.02.002

Cited by 74 publications

(45 citation statements)

References 222 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Though the GSD diet is enriched in starch and fibers, usually considered good substrates promoting beneficial microbes' growth, Proteobacteria, in particular, the Enterobacteriaceae family, have been suggested to exert pro-inflammatory activity both locally, at the gastrointestinal mucosa level, and systemically [28]. In turn, an inflamed gut seems to constitute a commending environment for proliferation of Enterobacteriaceae bacteria [29], and it is also characterized by a depletion of obligate anaerobes, typically recognized as fiber-degrading bacteria [30].…”

Section: Discussionmentioning

confidence: 99%

Proteobacteria Overgrowth and Butyrate-Producing Taxa Depletion in the Gut Microbiota of Glycogen Storage Disease Type 1 Patients

et al. 2020

View full text Add to dashboard Cite

A life-long dietary intervention can affect the substrates’ availability for gut fermentation in metabolic diseases such as the glycogen-storage diseases (GSD). Besides drug consumption, the main treatment of types GSD-Ia and Ib to prevent metabolic complications is a specific diet with definite nutrient intakes. In order to evaluate how deeply this dietary treatment affects gut bacteria, we compared the gut microbiota of nine GSD-I subjects and 12 healthy controls (HC) through 16S rRNA gene sequencing; we assessed their dietary intake and nutrients, their microbial short chain fatty acids (SCFAs) via gas chromatography and their hematic values. Both alpha-diversity and phylogenetic analysis revealed a significant biodiversity reduction in the GSD group compared to the HC group, and highlighted profound differences of their gut microbiota. GSD subjects were characterized by an increase in the relative abundance of Enterobacteriaceae and Veillonellaceae families, while the beneficial genera Faecalibacterium and Oscillospira were significantly reduced. SCFA quantification revealed a significant increase of fecal acetate and propionate in GSD subjects, but with a beneficial role probably reduced due to unbalanced bacterial interactions; nutritional values correlated to bacterial genera were significantly different between experimental groups, with nearly opposite cohort trends.

show abstract

Section: Discussionmentioning

confidence: 99%

Proteobacteria Overgrowth and Butyrate-Producing Taxa Depletion in the Gut Microbiota of Glycogen Storage Disease Type 1 Patients

et al. 2020

View full text Add to dashboard Cite

show abstract

“…As in mammals, the intestinal microbiota can assist the digestion, immunity and reproduction of the fish (Reinoso, Koboziev, Furr, & Grisham, ; Zarkasi et al, ). However, the function of the microbiota is closely related to its composition (Bairagi, Ghosh, Sen, & Ray, ; Miao et al, ).…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary soybean meal associated with feeding time on the growth performance and intestinal microbiota composition of northern snakehead

et al. 2019

View full text Add to dashboard Cite

Fishmeal has placed increasing pressure on the cost of aquafeeds and wild fish stocks; therefore, plant-based protein sources have attracted more and more attention because of their relative competitive prices and availability. For example, using soybean meal to replace 27.3% fishmeal has been proven to be an effective way to reduce the cost of aquafeeds while maintaining the growth Abstract A 63-day growth trial was conducted with northern snakehead Channa argus to evaluate how rapidly its growth performance and how reproducibly its gut microbiota respond to different dietary protein sources. Four diets were formulated with different levels of soybean meal as a replacement for fishmeal (0%, 25%, 50% and 75%). Each diet was fed to three replicates of juvenile C. argus (30 juveniles per replicate, initial weight 8.65 ± 0.25 g) to produce groups G1, G2, G3 and G4 respectively. During this trial, survival rate, growth performance and intestinal microbiota composition were determined on days 9, 21 and 63. At day 9, there was no effect of the dietary soybean meal on the final weight (Wt), weight gain (WG) and specific growth rate (SGR) between the four groups (p > 0.05). However, at day 21 (p < 0.05), they were significantly lower in G4 fish than that in G1 and G2. The highest Wt, WG and SGR were found in G1 and G2 fish, the lowest growth was found in G4 fish at day 63 (p < 0.05). Furthermore, higher operational taxonomic units (OTUs) and alpha diversity were found in G4. With the dietary soybean level increased, the proportion of Firmicutes, Bacteroidetes and Verrucomicrobia, as well as some genera of bacteria (Carnobacterium, Cetobacterium, Planctomyces, Shewanella and Thermomonas) significantly increased in the G3 and G4 fish (p < 0.05). However, the OTUs, Chao index, and the proportion of Firmicutes and some genera (Acinetobacter, Bacillus and Geobacillus) in G4 fish were significantly higher at days 21 and 63 than that at day 9 (p < 0.05).Taken together, in response to dietary soybean meal levels, dynamic and significant changes in microbiota occurred, which then ultimately attained a new equilibrium. K E Y W O R D Sdynamic changes, feeding time, growth performance, microbiota composition, northern snakehead, soybean meal level

show abstract

“…Coexistence between the host and the gut microbiota helps to shape the mucosal and systemic immune systems. When the gut microbiota invades intestinal tissue and induces local or systemic inflammation, the mucosal immune system has a number of protective mechanisms that allow the host to mount an appropriate immune response to invading bacteria [ 6 ]. The intestinal microbiota is considered to be a significant factor in the aetiology of IBD [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota drives the attenuation of dextran sulphate sodium-induced colitis by Huangqin decoction

et al. 2017

View full text Add to dashboard Cite

The gut microbiota, including probiotics and pathogenic microorganisms, is involved in ulcerative colitis (UC) by regulating pathogenic microorganisms and the production of intestinal mucosal antibodies. Huangqin decoction (HQD), a traditional Chinese formula chronicled in the Shanghan lun, has been recognized as an effective drug for UC, owing to its anti-inflammatory and anti-oxidative properties. In the present study, we investigated whether HQD ameliorates dextran sulphate sodium (DSS)-induced colitis through alteration of the gut microbiota. We found that HQD significantly inhibited colitis, alleviating the loss of body weight, disease activity index, colon shortening, tissue injury, and inflammatory cytokine changes induced by DSS treatment. Principal component analysis and principal co-ordinate analysis showed an obvious difference among the groups, with increased diversity in the DSS and DSS+HQD groups. Linear discriminant analysis effect size was used to determine differences between the groups. The relative abundance of Lactococcus was higher in the DSS+HQD group than in the DSS group, whereas Desulfovibrio and Helicobacter were decreased. Furthermore, the protective effect of HQD was attenuated only in antibiotic-treated mice. In conclusion, our results suggest that HQD could ameliorate DSS-induced inflammation through alteration of the gut microbiota.

show abstract

Protective and pro-inflammatory roles of intestinal bacteria

Cited by 74 publications

References 222 publications

Proteobacteria Overgrowth and Butyrate-Producing Taxa Depletion in the Gut Microbiota of Glycogen Storage Disease Type 1 Patients

Proteobacteria Overgrowth and Butyrate-Producing Taxa Depletion in the Gut Microbiota of Glycogen Storage Disease Type 1 Patients

Effect of dietary soybean meal associated with feeding time on the growth performance and intestinal microbiota composition of northern snakehead

Gut microbiota drives the attenuation of dextran sulphate sodium-induced colitis by Huangqin decoction

Contact Info

Product

Resources

About