Protective and anticancer effects of orange peel extract and naringin in doxorubicin treated esophageal cancer stem cell xenograft tumor mouse model

Tajaldini, Mahboubeh; Samadi, F.; Khosravi, Ayyoob; Ghasemnejad, A.; Asadi, Jahanbakhsh

doi:10.1016/j.biopha.2019.109594

Cited by 65 publications

(38 citation statements)

References 26 publications

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“…Recent works demonstrated that the combination of herbal medicines and chemotherapy drugs have several advantages. One study showed that treatment with naringin alone or combined with DOX reduced cell viability and proliferation in YM1 esophageal cancer cell line, and reduced tumor size in xenograft mice tumor model (Tajaldini et al, 2020). An in vivo study indicated that naringin treatment markedly reduced tumor size and growth, and also significantly decreased tumor burden in the hamster cheek pouch oral cancer model (Miller et al, 2008).…”

Section: Esophageal/head and Neck Cancermentioning

confidence: 99%

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

et al. 2021

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Background: Natural product-based cancer preventive and therapeutic entities, such as flavonoids and their derivatives, are shown to have a noticeable capability to suppress tumor formation and cancer cell growth. Naringin, a natural flavanone glycoside present in various plant species, has been indicated to modulate different signaling pathways and interact with numerous cell signaling molecules, which allows for an extensive variety of pharmacological actions, such as amelioration of inflammation, oxidative stress, metabolic syndromes, bone disorders, and cancer. The purpose of this systematic review is to present a critical and comprehensive assessment of the antitumor ability of naringin and associated molecular targets in various cancers.Methods: Studies were identified through systematic searches of Science Direct, PubMed, and Scopus as well as eligibility checks according to predefined selection criteria.Results: Eighty-seven studies were included in this systematic review. There was strong evidence for the association between treatment with naringin alone, or combined with other drugs and antitumor activity. Additionally, studies showed that naringin-metal complexes have greater anticancer effects compared to free naringin. It has been demonstrated that naringin employs multitargeted mechanisms to hamper cancer initiation, promotion, and progression through modulation of several dysregulated signaling cascades implicated in cell proliferation, autophagy, apoptosis, inflammation, angiogenesis, metastasis, and invasion.Conclusion: The results of our work show that naringin is a promising candidate for cancer prevention and treatment, and might offer substantial support for the clinical application of this phytocompound in the future. Nevertheless, further preclinical and clinical studies as well as drug delivery approaches are needed for designing novel formulations of naringin to realize the full potential of this flavonoid in cancer prevention and intervention.

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Section: Esophageal/head and Neck Cancermentioning

confidence: 99%

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

et al. 2021

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“…Quercetin can synergize cisplatin-induced mitochondrial apoptosis via downregulating Cu/Zn SOD which leads to elevated ROS in larynx cancer Hep2 cells [216]. Naringin has a protective role in doxorubicin-induced toxicity towards normal tissues without sacrificing its anticancer effect by elevating SOD and total antioxidant capacity against the esophageal cancer stem cell YM1 in xenograft nude mice [217]. Alpinumisoflavone (AIF) could significantly increase the radiosensitivity of esophageal squamous cell carcinoma (ESCC) indicated by enhanced apoptosis, DNA damage, and cell cycle arrest which are mechanically achieved by ROS generation and Nrf2 antioxidant system inhibition both in vitro and in vivo [218].…”

Section: Oxidative Medicine and Cellular Longevitymentioning

confidence: 99%

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

Huang

Pan

2020

Oxidative Medicine and Cellular Longevity

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Head and neck cancer is a highly genetic and metabolic heterogeneous collection of malignancies of the lip, oral cavity, salivary glands, pharynx, esophagus, paranasal sinuses, and larynx with five-year survival rates ranging from 12% to 93%. Patients with head and neck cancer typically present with advanced stage III, IVa, or IVb disease and are treated with comprehensive modality including chemotherapy, radiotherapy, and surgery. Despite advancements in treatment modality and technique, noisome recurrence, invasiveness, and resistance as well as posttreatment complications severely influence survival rate and quality of life. Thus, new therapeutic strategies are urgently needed that offer enhanced efficacy with less toxicity. ROS in cancer cells plays a vital role in regulating cell death, DNA repair, stemness maintenance, metabolic reprogramming, and tumor microenvironment, all of which have been implicated in resistance to chemo-/radiotherapy of head and neck cancer. Adjusting ROS generation and elimination to reverse the resistance of cancer cells without impairing normal cells show great hope in improving the therapeutic efficacy of chemo-/radiotherapy of head and neck cancer. In the current review, we discuss the pivotal and targetable redox-regulating system including superoxide dismutases (SODs), tripeptide glutathione (GSH), thioredoxin (Trxs), peroxiredoxins (PRXs), nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/keap1), and mitochondria electron transporter chain (ETC) complexes and their roles in regulating ROS levels and their clinical significance implicated in chemo-/radiotherapy of head and neck cancer. We also summarize several old drugs (referred to as the non-anti-cancer drugs used in other diseases for a long time) and small molecular compounds as well as natural herbs which effectively modulate cellular ROS of head and neck cancer to synergize the efficacy of conventional chemo-/radiotherapy. Emerging interdisciplinary techniques including photodynamic, nanoparticle system, and Bio-Electro-Magnetic-Energy-Regulation (BEMER) therapy are promising measures to broaden the potency of ROS modulation for the benefit of chemo-/radiotherapy in head and neck cancer.

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“…Luteolin has also presented a synergetic effect in lung cancer treatment with tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) [67]. Moreover, the combined use of polyphenols with chemotherapy can be interesting to mitigate the side effects of treatment, such as reported in the work of Tajaldini et al [68], where they verified that the treatment against oesophageal cancer in mice using doxorubicin combined with naringin or orangepeel extract inhibited tumour growth, successfully increased apoptotic cell death, and in contrast to the chemotherapy used alone, resulted in lower systemic toxicity, decreased oxidative stress, and body weight maintenance.…”

Section: Cancermentioning

confidence: 99%

Food Bioactive Compounds and Emerging Techniques for Their Extraction: Polyphenols as a Case Study

Câmara

Albuquerque

Aguiar

et al. 2020

Foods

107

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Experimental studies have provided convincing evidence that food bioactive compounds (FBCs) have a positive biological impact on human health, exerting protective effects against non-communicable diseases (NCD) including cancer and cardiovascular (CVDs), metabolic, and neurodegenerative disorders (NDDs). These benefits have been associated with the presence of secondary metabolites, namely polyphenols, glucosinolates, carotenoids, terpenoids, alkaloids, saponins, vitamins, and fibres, among others, derived from their antioxidant, antiatherogenic, anti-inflammatory, antimicrobial, antithrombotic, cardioprotective, and vasodilator properties. Polyphenols as one of the most abundant classes of bioactive compounds present in plant-based foods emerge as a promising approach for the development of efficacious preventive agents against NCDs with reduced side effects. The aim of this review is to present comprehensive and deep insights into the potential of polyphenols, from their chemical structure classification and biosynthesis to preventive effects on NCDs, namely cancer, CVDs, and NDDS. The challenge of polyphenols bioavailability and bioaccessibility will be explored in addition to useful industrial and environmental applications. Advanced and emerging extraction techniques will be highlighted and the high-resolution analytical techniques used for FBCs characterization, identification, and quantification will be considered.

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Protective and anticancer effects of orange peel extract and naringin in doxorubicin treated esophageal cancer stem cell xenograft tumor mouse model

Cited by 65 publications

References 26 publications

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

Food Bioactive Compounds and Emerging Techniques for Their Extraction: Polyphenols as a Case Study

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