Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammation

Celastrus and Its Bioactive Celastrol Protect against Bone Damage in Autoimmune Arthritis by Modulating Osteoimmune Cross-talk

“…For example, green tea has been shown to synergize with ␣-calcidol in affording protection against inflammation-induced bone loss in rats, and this effect was attributable to a reduction in TNF-␣ production as well as oxidative stress damage and inflammation (50,51). Epigallocatechin gallate, a bioactive component of green tea, has been reported to inhibit IL-6, a critical proinflammatory cytokine involved in inflammation and bone damage in arthritis (52).…”

Green tea polyphenols and their potential role in health and disease

“…The anti-inflammatory activity of polyphenols in green tea extract (GTE) has been demonstrated in various models of acute inflammation (Singh et al 2010;Relja et al 2012;Shen et al 2011Shen et al , 2012, and numerous mechanisms have been suggested for their anticancer activities including suppression of NF-kappaB, inflammasome, and IL-1beta secretion (Lamoral-Theys et al 2010;Ellis et al 2011). Many malignancies are characterized by an activation of interleukin-associated kinases, and several drugs targeting specific kinases, both natural and synthetic, are being used for cancer treatment (Guo et al 2015;Kim et al 2015).…”

Green tea protects human osteoblasts from cigarette smoke-induced injury: possible clinical implication

“…Besides their function to directly scavenge ROS like the superoxide anion, oxygen singlet, and lipidic peroxyradicals, they can stabilize free ROS by means of hydrogenation or formation of complexes with oxidating species [23][24][25]. Based on that, polyphenols have been shown to have numerous biochemical and physiological benefits, including antioxidant, anti-microbial, anti-inflammatory, and cytoprotective activities [23,[26][27][28]. Clinical observations suggest that consuming green tea increases bone density and therefore reduces the risk of osteoporotic fractures [29,30].…”