Protective action of aqueous black tea (<i>Camellia sinensis</i>) extract (BTE) against ovariectomy‐induced oxidative stress of mononuclear cells and its associated progression of bone loss

Das, Asankur Sekhar; Mukherjee, Maitrayee; Das, Dolan; Mitra, Chandan

doi:10.1002/ptr.2719

Cited by 25 publications

(17 citation statements)

References 58 publications

(66 reference statements)

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“…Some reports have demonstrated that osteoclast differentiation is stimulated by oxidative stress [29]. These data indicate that oxidative stress plays a crucial role in osteoclast differentiation.…”

Section: Resultsmentioning

confidence: 67%

In-VivoEffect of Andrographolide on Alveolar Bone Resorption Induced byPorphyromonas gingivalisand Its Relation with Antioxidant Enzymes

Batran

Al-Bayaty

Al-Obaidi

2013

BioMed Research International

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Alveolar bone resorption is one of the most important facts in denture construction. Porphyromonas gingivalis (Pg) causes alveolar bone resorption, and morphologic measurements are the most frequent methods to identify bone resorption in periodontal studies. This study has aimed at evaluating the effect of Andrographolide (AND) on alveolar bone resorption in rats induced by Pg. 24 healthy male Sprague Dawley rats were divided into four groups as follows: normal control group and three experimental groups challenged orally with Pg ATCC 33277 five times a week supplemented with 20 mg/kg and 10 mg/kg of AND for twelve weeks. Alveolar bones of the left and right sides of the mandible were assessed by a morphometric method. The bone level, that is, the distance from the alveolar bone crest to cementumenamel junction (CEJ), was measured using 6.1 : 1 zoom stereomicroscope and software. AND reduced the effect of Pg on alveolar bone resorption and decreased the serum levels of Hexanoyl-Lysine (HEL); furthermore the reduced glutathione/oxidised glutathione (GSH/GSSG) ratio in AND treated groups (10 and 20 mg/kg) significantly increased when compared with the Pg group (P < 0.05). We can conclude that AND suppresses alveolar bone resorption caused by Pg in rats.

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Section: Resultsmentioning

confidence: 67%

In-VivoEffect of Andrographolide on Alveolar Bone Resorption Induced byPorphyromonas gingivalisand Its Relation with Antioxidant Enzymes

Batran

Al-Bayaty

Al-Obaidi

2013

BioMed Research International

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“…Moderate consumption of tea, which contains flavonoids closely related to soy isoflavones, has been reported to be associated with higher BMD in men and women [26, 27] and lower rates of fracture [32, 33]. Results of series of studies from our laboratory with aqueous black tea extract [34–36] further support the idea that phytocompounds have efficacy in preventing bone loss. This study aimed to examine the protective role of black tea extract (BTE) against nonalcoholic steatohepatitis- (NASH-) induced skeletal dysfunction.…”

Section: Introductionmentioning

confidence: 67%

Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction

Karmakar

Majumdar

Maiti

et al. 2011

Journal of Osteoporosis

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Aim. This paper aimed to examine the chemoprotective actions of aqueous black tea extract (BTE) against nonalcoholic steatohepatitis- (NASH-) induced skeletal changes in rats. Material. Wistar rats (body wt. 155–175 g) of both sexes, aged 4–5 months, were randomly assigned to 3 groups; Group A (control), Group B (60% high-fat diet; HFD), and Group C (HFD + 2.5% BTE). Methods. Several urinary (calcium, phosphate, creatinine, and calcium-to-creatinine ratio) serum (alkaline phosphatase and serum tartrate-resistant acid phosphatase), and molecular markers of bone turnover (receptor activator of NF-κB ligand (RANKL), osteoprotegerin (OPG), and estrogen) were tested. Also, several bone parameters (bone density, bone tensile strength, bone mineral content, and bone histology) and calcium homeostasis were checked. Results. Results indicated that HFD-induced alterations in urinary, serum, and bone parameters as well as calcium homeostasis, all could be significantly ameliorated by BTE supplementation. Conclusion. Results suggest a potential role of BTE as a protective agent against NASH-induced changes in bone metabolism in rats.

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“…Oxidative stress is regarded as a pivotal physiopathological process in the age-related bone loss [40]. Das AS et al showed that the black tea extract would protect the mononuclear cells from the oxidative stress and thus slowed the progression of bone loss [41]. Apart from the polyphenol, the other contents in tea, such as fluorine and caffeine, also play important roles in the bone health [37].…”

Section: Discussionmentioning

confidence: 99%

Tea consumption didn’t modify the risk of fracture: a dose–response meta-analysis of observational studies

Chen

Shi

2014

Diagn Pathol

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BackgroundFractures are important causes of healthy damage and economic loss nowadays. The conclusions of observational studies on tea consumption and fracture risk are still inconsistent. The objective of this meta-analysis is to determine the effect of tea drinking on the risk of fractures.MethodsA comprehensive literature search was conducted in PubMed, Embase and reference lists of the relevant articles. Observational studies that reported an estimate of the association between tea drinking and incidence of fractures were included. A meta-analysis was conducted by the STATA software.ResultsA total of 9 studies involving 147,950 individuals that examined the association between tea consumption and risk of fractures were included in this meta-analysis. The odds risks (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model. The pooled OR of 9 observational studies for the tea consumption on risk of fracture was 0.89 (95% CI, 0.78-1.04). In the subgroup analyses, no significant association was detected in neither cohort studies (n = 3; OR, 0.97; 95% CI, 0.89-1.06) nor case–control studies (n = 6; OR, 0.91; 95% CI, 0.70-1.19), respectively. No significant association was detected in the dose–response meta-analysis.ConclusionsTea consumption might not be associated with the risk of fractures. The following large-sample and well-designed studies are required to confirm the existing conclusions.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5309904231178427.

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Protective action of aqueous black tea (Camellia sinensis) extract (BTE) against ovariectomy‐induced oxidative stress of mononuclear cells and its associated progression of bone loss

Cited by 25 publications

References 58 publications

In-VivoEffect of Andrographolide on Alveolar Bone Resorption Induced byPorphyromonas gingivalisand Its Relation with Antioxidant Enzymes

In-VivoEffect of Andrographolide on Alveolar Bone Resorption Induced byPorphyromonas gingivalisand Its Relation with Antioxidant Enzymes

Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction

Tea consumption didn’t modify the risk of fracture: a dose–response meta-analysis of observational studies

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