Protection on Skin Aging Mediated by Antiapoptosis Effects of the Water Lily (&lt;b&gt;&lt;i&gt;Nymphaea Tetragona&lt;/i&gt;&lt;/b&gt; Georgi) via Reactive Oxygen Species Scavenging in Human Epidermal Keratinocytes

Park, Gunhyuk; Sim, Yeomoon; Lee, Wonil; Sung, Sang Hyun; Oh, Myung Sook

doi:10.1159/000444022

Cited by 12 publications

(9 citation statements)

References 27 publications

(43 reference statements)

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“…Furthermore, biliverdin can be converted by the enzyme biliverdin reductase into bilirubin, a potent antioxidant, capable of protecting cells from 10,000-fold higher concentrations of H 2 O 2 ( (Morse , Choi, 2005)). Activation of HO-1 was described already as a possible mechanism by which different natural compounds delay skin aging (Park et al, 2016).…”

Section: Ros Mitochondrial Dna and Agingmentioning

confidence: 99%

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi

Marchi

Simões

et al. 2018

International Review of Cell and Molecular Biology

269

162

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Aging has been linked to several degenerative processes that, through the accumulation of molecular and cellular damage, can progressively lead to cell dysfunction and organ failure. Human aging is linked with a higher risk for individuals to develop cancer, neurodegenerative, cardiovascular, and metabolic disorders. The understanding of the molecular basis of aging and associated diseases has been one major challenge of scientific research over the last decades. Mitochondria, the center of oxidative metabolism and principal site of reactive oxygen species (ROS) production, are crucial both in health and in pathogenesis of many diseases. Redox signaling is important for the modulation of cell functions and several studies indicate a dual role for ROS in cell physiology. In fact, high concentrations of ROS are pathogenic and can cause severe damage to cell and organelle membranes, DNA, and proteins. On the other hand, moderate amounts of ROS are essential for the maintenance of several biological processes, including gene expression. In this review, we provide an update regarding the key roles of ROS-mitochondria cross talk in different fundamental physiological or pathological situations accompanying aging and highlighting that mitochondrial ROS may be a decisive target in clinical practice.

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Section: Ros Mitochondrial Dna and Agingmentioning

confidence: 99%

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi

Marchi

Simões

et al. 2018

International Review of Cell and Molecular Biology

269

162

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“…Similarly, other natural extracts, such as those from Nymphaea tetragona Georgi and Schisandra chinensis (Turcz.) Baill (from which deoxyschisandrin was isolated), have been shown to possess ROS scavenging antioxidant properties (Park et al 2016;Hou et al 2015). When ROS generation and antioxidant capacity are in relative balance, the expression of specific nuclear genes can be modulated to maintain the energy metabolism necessary for the cell's survival.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, ROS generation is considered to be an additional critical mediator in triggering the apoptotic machinery (Ichihashi et al 2003). Recent studies demonstrated that ROS may cause oxidative damage to the DNA, RNA, proteins, and lipids of affected cells and induce apoptosis through the induction of mitochondrial membrane permeability transition and the release of pro-apoptotic proteins when ROS levels exceed a certain threshold (Park et al 2016;Ueda et al 2002;Maraldi et al 2009). In brief, excessive ROS levels downregulate anti-apoptotic proteins and upregulate pro-apoptotic proteins, resulting in interference with the normal release of cytochrome-c, which activates the caspase family proteins, and finally induces cell death (Ryu et al 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, an excessive accumulation of ROS can cause oxidative damage to cellular macromolecules, including DNA modification, lipid peroxidation, and apoptotic signal transduction, which alters cellular function (Fernando et al 2016;Tu and Tawata 2015;Briganti and Picardo 2003). These damages are usually accompanied by an increase in keratinocyte apoptosis and a decrease in epidermal cell proliferation, which may accelerate skin aging and increase the risk of some skin disorders, including skin cancer (Park et al 2016).…”

Section: Introductionmentioning

confidence: 99%

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Protective skin aging effects of cherry blossom extract (Prunus Yedoensis) on oxidative stress and apoptosis in UVB-irradiated HaCaT cells

Wang¹,

Xu³

et al. 2019

Cytotechnology

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Extracts of the cherry blossom plant have been reported to exert various biological effects on human cells. However, no previous investigations have examined the antioxidant and anti-apoptotic effects of these extracts on ultraviolet B (UVB) radiation-induced skin aging. This study explores the underlying mechanisms of the antioxidant and antiapoptotic effects of cherry blossom extract (CBE) in human keratinocyte (HaCaT) cells. HaCaT cells were treated with CBE at concentrations of 0.5, 1.0, and 2.0% for 24 h and then irradiated with UVB (40 mJ/ cm 2). CBE effectively and dose-dependently decreased the levels of reactive oxygen species and malondialdehyde, while increasing the activities of superoxide dismutase and glutathione peroxidase. Pretreatment with 1 and 2% CBE attenuated UVBinduced DNA damage by reducing the formation of cyclobutane pyrimidine dimers and 8-hydroxy-20deoxyguanosine. Furthermore, CBE also prevented UVB-induced apoptosis and significantly downregulated B cell lymphoma 2 (Bcl-2)-associated X, cytochrome-c, and caspase-3 expression, while upregulating Bcl-2 expression. Taken together, these results indicate that CBE protects HaCaT cells from UVBinduced oxidative stress and apoptosis and suggest that CBE could be a potent antioxidant against skin aging.

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“…The values indicate 50% decrease of ABTS radical. DPPH radical 소거능의 경우에는 유리라디칼이 소거되어지 는 것을 이용하는 반면, ABTS radical 소거능은 양이온인 라디 칼이 소거되어지는 것을 이용한다 [28]. 부평초의 용매별 추출 물의 ABTS radical 소거능을 비교한 결과는 Table 2와 같다.…”

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Total Phenols, Flavonoid Contents, and Antioxidant Activity of Spirodela polyrhiza Extracts

송원영¹,

최정화²

2017

Journal of Life Science

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We investigated the antioxidant activities of water and ethanol extracts from Spirodela polyrhiza (SP) through in vitro assays. The total phenolic contents of SP water and ethanol extracts were 52.75-293.4 and 60.12-398.4 mg/g, respectively. The total flavonoid content of SP ethanol extract (38.25-159.4 mg/g) was higher than that of SP water extract (38.25-67.75 mg/g). The water and ethanol extracts from SP scavenged the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 2,2'-azino-di-2-ethyl-benzothia-zoline sulfonate (ABTS) radical in a dose-dependent manner in the concentration range of 100-2,500 μg/ml. The DPPH radical scavenging activity of the SP ethanol extract (2.87%-59.5%) was higher than that of the water extract (4.12%-81.52%). The IC50s of the DPPH radical scavenging activity of water and ethanol extracts were 2,100 and 1,034 μg/ml respectively. The ABTS radical scavenging activities of SP water and ethanol extracts were 8.30%-83.16% and 13.11%-8.34% respectively. The IC50s of the ABTS radical scavenging activity of SP water and ethanol extracts were 798.7 and 457.1 μg/ml, respectively. The reducing power activities of SP water and ethanol extracts were 0.055-1.122 and 0.140-1.428, respectively (500-4,000 μg/ml). The soybean lipoxygenase (SLO) radical scavenging activities of SP water and ethanol extracts were 157.7%-168.0% and 148.0%-169.4%, respectively. These results suggest that the water and ethanol extracts of SP may be useful as a potential antioxidant.

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Protection on Skin Aging Mediated by Antiapoptosis Effects of the Water Lily (<b><i>Nymphaea Tetragona</i></b> Georgi) via Reactive Oxygen Species Scavenging in Human Epidermal Keratinocytes

Cited by 12 publications

References 27 publications

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Protective skin aging effects of cherry blossom extract (Prunus Yedoensis) on oxidative stress and apoptosis in UVB-irradiated HaCaT cells

Total Phenols, Flavonoid Contents, and Antioxidant Activity of Spirodela polyrhiza Extracts

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