Protection of thermochemotherapeutic-induced lethal acute hepatic necrosis in the rat by 16,16-dimethyl prostaglandin E2

Miyazaki, M.; Makowka, Leonard; Falk, R. E.; Falk, Judith A.; McDonell, Michele; Venturi, David

doi:10.1016/0022-4804(83)90090-2

Cited by 26 publications

(10 citation statements)

References 7 publications

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“…It has been previously shown that endogenous PGE 2 released mainly from activated Kupffer cells via the upregulation of COX‐2 expression protects hepatic I/R injury 18, 19. In addition, exogenous PGE 2 has been reported to have a beneficial effect on hepatic injury in a variety of experimental models, including liver failure induced by endotoxin and certain drugs 20–22. Although these studies suggest that PGE 2 plays an important role in hepatic injury, the underlying mechanisms for the protective effect of PGE 2 signal transduction in the liver have not been fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…In the liver, endogenous PGE 2 has been suggested to be produced mainly by activated Kupffer cells during hepatic injury 18, 19. Previous studies have demonstrated that both endogenous and exogenous PGE 2 are protective against liver injury caused by I/R as well as the other hepatic disorders 20–22. This effect may be associated with increased liver perfusion, inhibition of platelet aggregation, and direct cytoprotection by PGE 2 23.…”

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confidence: 99%

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Comparison of Actigraphic and Subjective Measures of Sleep in Implantable Cardioverter Defibrillator and Coronary Artery Disease Patients

Cross

McCrae

Smith

et al. 2010

Clinical Cardiology

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Background:Cardiac patients frequently have insomnia symptoms that may pose risk for future cardiac events. Poor sleep relates to hyperarousal, anxiety and depression, and the incidence of hypertension and myocardial infarction.Hypothesis:The authors hypothesized that implantable cardioverter defibrillator (ICD) patients would have poorer sleep than coronary artery disease (CAD) patients related to hypervigilance for device functioning and shock discharge.Methods:Authors investigated sleep efficiency and sleep latency in a sample of 60 patients (n = 30 CAD and n = 30 ICD) without obstructive sleep apnea at the University of Florida & Shands Hospital. For 14 days, participants completed a sleep diary. Additionally, half of the total sample also used actigraphy to objectively measure their sleep. Measures of somatic hypervigilance and psychosocial distress were administered.Results:Using actigraphy, mean sleep efficiency was poorer (69.76%) in CAD patients compared with ICD patients (82.80%). This difference was highly significant, F1,27 = 16.840, P < 0.001. CAD patients also had shorter mean total sleep times per sleep diaries compared with ICD patients (336.19 minutes or 5.60 hours, 430.65 minutes or 7.18 hours, respectively), F1,27 = 15.908, P < 0.001.Conclusions:The finding that ICD patients slept more efficiently than CAD patients is surprising given that CAD patients had higher ejection fractions and no concerns about ICD shocks. This difference cannot be accounted for by differences in hypervigilance, depression, anxiety, or physical activity. Results suggest that CAD patients may have more sleep problems and may warrant increased research attention. Copyright © 2010 Wiley Periodicals, Inc.Dr. Sears serves as a consultant to Medtronic, has or has had research grants from Medtronic and St. Jude Medical, and has received speaker honoraria from Medtronic, Boston Scientific, St. Jude Medical, and Biotronik. Dr. Conti serves as a consultant to Medtronic, has or has had research grants from Medtronic and St. Jude Medical, and has received speaker honoraria from Medtronic, Boston Scientific, and St. Jude Medical. The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Comparison of Actigraphic and Subjective Measures of Sleep in Implantable Cardioverter Defibrillator and Coronary Artery Disease Patients

Cross

McCrae

Smith

et al. 2010

Clinical Cardiology

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“…Hickman et al have found the thermochemotherapeutic rat model of Miyazaki et al [17] to be unreliable and not reproducible in the pig (unpublished obser vations) as has been the administration of galactosamine. Acetaminophen which pro duces hepatic necrosis in hamsters [3] was proved unreliable in pigs [15], Yellow phos phorus has a predictably lethal effect in dogs but remains dangerous to its users even after administration to the animal [2].…”

Section: Introductionmentioning

confidence: 99%

A Predictable Pathophysiological Model of Porcine Hepatic Failure

Hickman¹,

Alp²

1986

Eur Surg Res

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A technique is described in which acute hepatic failure may be uniformly induced in pigs using a combination of oral phenobarbitone pretreatment and 2-hour interruption of hepatic arterial blood supply followed by intragastric carbon tetrachloride. This results in deep hepatic coma over a narrowly predictable time span and death within 12–52 h. Amino acid levels in plasma and cerebrospinal fluid obtained 24 h after the induction of hepatic failure were similar to those reported in human and experimental encephalopathy.

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“…Experimentally, the degree of sensitivity of the dog or rat liver to hyperthermia is still imprecise as reflected by the conflicting data obtained from the literature [1,4,9,12,13,18,22], These variations are probably ex plained by variations in the technique of hy perthermia, in the duration of hyperthermia and by differences in the monitoring of intrahepatic temperatures during hyperthermia. Concerning the technique of hyperthermia, it is probable that, in addition to liver heating, whole body-hyperthermia and hyperthermic isolated liver perfusion have their own ad verse effects due to the extrahepatic conse quences of heating in the first case, and to the consequences of liver ischemia, portal and caval clamping in the second.…”

Section: Discussionmentioning

confidence: 92%

“…Hyperthermia has signif icant potential for the treatment of multifocal primary or secondary malignant liver tumors [23] for which standard therapies have been disappointing. However, little is known about the toxicity of hyperthermia to the liver: ex perimental studies [1,2,6,18,22] and clinical observations using total-body hyperthermia [14] have underlined the risk of injury to liver parenchymal cells, but the relation be tween the degree of hyperthermia and the extent of hepatocellular injury is not clear.In the rat, the thinness of the liver permits poorly penetrating infrared radiation to be used for the study of liver hyperthermia. The purpose of this experimental study in the rat was to precisely define the thermosensitivity of the normal liver and of the neoplastic liver to infrared hyperthermia and the conditions required for using hyperthermia as a treat ment for experimental malignant liver tu mors in the rat.…”

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confidence: 99%

Effects of Hyperthermia on Normal or Neoplastic Rat Liver

Adam¹,

Poggi²,

Houssin³

et al. 1985

Eur Surg Res

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An experimental study was conducted in rats to evaluate the sensitivity of the liver to infrared hyperthermia. A 15-min hyperthermia session treating only the liver was done in rats with a normal hepatic parenchyma and in rats with hepatocarcinoma induced by chronic 3’-diethylaminoazobenzene intoxication, at various ranges of intrahepatic temperature. In normal rats, 40–42 °C hyperthermia was well tolerated, but the mortality rate increased when the intrahepatic temperature exceeded 42 °C. In rats with tumors, a 40–42 °C hyperthermia session was well tolerated in case of small tumors, but resulted in a high mortality rate in case of large tumors. In all cases, death occurred as a consequence of liver injury. This study using a simple method of hyperthermia defines the thermosensitivity of the neoplastic or normal rat liver and provides a basis for further investigations on the effect of hyperthermia on experimental liver tumors.

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Protection of thermochemotherapeutic-induced lethal acute hepatic necrosis in the rat by 16,16-dimethyl prostaglandin E2

Cited by 26 publications

References 7 publications

Comparison of Actigraphic and Subjective Measures of Sleep in Implantable Cardioverter Defibrillator and Coronary Artery Disease Patients

Comparison of Actigraphic and Subjective Measures of Sleep in Implantable Cardioverter Defibrillator and Coronary Artery Disease Patients

A Predictable Pathophysiological Model of Porcine Hepatic Failure

Effects of Hyperthermia on Normal or Neoplastic Rat Liver

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