Protection of Saccharomyces cerevisiae against Oxidative and Radiation-Caused Damage by Alkylhydroxybenzenes

Stepanenko, I. Yu.; Strakhovskaya, M. G.; Belenikina, N. S.; Nikolaev, Yu. A.; Mulyukin, A. L.; Kozlova, A. N.; Ревина, А. А.; Эль-Регистан, Г. И.

doi:10.1023/b:mici.0000023984.42794.21

Cited by 16 publications

(14 citation statements)

References 9 publications

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“…In turn, reduction of AR concentrations down to 10 -5 M , o r a n i n c r e a s e u p t o 1 0 -3 M accompanied by a corresponding weakening or strengthening of such a UV-protective effect. These data are well corresponding with earlier findings, characterizing the alkylresorcinols as factors that protect the bacteria and yeast cells from the ultraviolet and ionizing radiation Il'inskaya et al, 2002;Stepanenko et al, 2004].…”

Section: Bacterial Cells Uv Protection By Arsupporting

confidence: 92%

“…These molecules are synthesized by bacteria, fungi and plants Kozubek & Tyman, 1999;Zarnowski et al, 1999] and had different functions , including the control of microorganisms transition in a dormant state [Mulyukin et al, 2003]. An important requirement for this process is the preservation and stabilization of a wide range of itracell biological macromolecules, including DNA [Solyanikova et al, 2011;Stepanenko et al, 2004]. This suggesting the role of AR in the protection of the biopolymer from UV exposure.…”

Section: Discussionmentioning

confidence: 99%

“…The effect of AR interaction with the enzyme proteins appears in change of the rate of catalysis [Martirosova et al, 2004] and the spectrum of substrate specificity [Petrovskii et al, 2009] with a synchronous significant increase of protein globules stability to various extreme factors [Solyanikova et al, 2011]. Results of AR interaction with biopolymers and supramolecular structures in the whole cell are the control of metabolic processes, including their inhibition and the formation of cyst-like forms of microorganisms , characterized by increased resistance to different stress factors [Stepanenko et al, 2004].…”

Section: Introductionmentioning

confidence: 99%

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Alkylresorcinols Protect the DNA from UV-Damage In Vitro and In Vivo Models

Deryabin¹,

Davydova²,

Gryazeva³

2012

Products and Applications of Biopolymers

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Section: Bacterial Cells Uv Protection By Arsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alkylresorcinols Protect the DNA from UV-Damage In Vitro and In Vivo Models

Deryabin¹,

Davydova²,

Gryazeva³

2012

Products and Applications of Biopolymers

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“…According to Stepanenko et al [60], resorcinols/ cardol can repair DNA damage. The later one is present in both iCNSL and tCNSL, thus the damage repair activity may linked with.…”

Section: Discussionmentioning

confidence: 99%

Net effects of cashew nuts in Saccharomyces cerevisiae front to damage induced by hydrogen peroxide

Leite¹,

Gomes²,

Oliveira³

et al. 2016

Int Arch Med

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Cellular injury associated with oxidative stress has been related in the etiology and progression of many diseases, including neurodegenerative diseases and cancer. Shell of cashew nut releases the alkylphenols oil, known as cashew nut shell liquid (CNSL), which can be characterized according to the method of production such as technical (tCNSL) and in natural (iCNSL) types. This study aimed to characterize the chemical constituents in both liquids by gas chromatography coupled to mass spectrometry (GC-MS), and to evaluate the net effect of them in proficient (SODWT) and deficient (Sod1∆, Sod2∆, Cat1∆, Sod1∆Sod2∆, Sod1∆Cat1∆) Saccharomyces cerevisiae oxidative damaged induced by hydrogen peroxide (H 2 O 2 (10 mM); stressor) at concentrations of 17.37, 34.7 and 69.5 µg/ml in pre-, co-and post-treatment. Both iCNSL and tCNSL produced no oxidizing effect to the tested yeast strains, otherwise they protected against damage induced by stressor (STR). However, tCNSL was found more prominent than the iCNSL in restorative activity. In conclusion, CNSLs (iCNSL/tCNSL) exhibited excellent protective, antioxidant and repair capabilities compared to the damage induced by STR in S. cerevisiae cells, thus may be a suggestion for its biotechnological production especially for pharmaceutical account.

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“…In addition, it can prevent and repair damage done to DNA (Stepanenko et al, 2004). A recent study indicated that a new resorcinolic lipid, 3-heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one (AMS35AA) alone produced neither genotoxic nor mutagenic effects in mice (Navarro et al, 2014).…”

Section: A Occidentale and Its Biological Rolesmentioning

confidence: 99%

Pharmacological properties of cashew (Anacardium occidentale)

Leite¹,

Islam²,

Junior³

et al. 2016

Afr. J. Biotechnol.

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Anacardium occidentale L. is a tree native to Brazil, which is rich in phenolic lipids. Nowadays, the cashew bark (Cashew Nut Shell Liquid) has received great attention in the pharmaceutical industry, due to its economy, abundance and important chemical compounds. Net of cashew nut shell is classified according to the method of production of: (1) net of the shell of natural cashew nut (60-65% anacardic acid; 15-20% cardol and 10% of cardanol) and (2) liquid from the technical cashew nut shell (60-65% of cardanol, 15-20% cardol and 10% of polymeric material). This work aims to report the pharmacological properties of liquids from cashew nut shells. Results suggest that both liquids have antifungal, antibacterial, antiparasitic, anti-tumor, antiulcerogenic, molluscicides, antimutagenic and antioxidant activities. Natural cashew nut liquid is non-genotoxic, whereas technical liquid is genotoxic in prokaryotes and eukaryotes, although there is no evidence of their mutagenic effects on eukaryotic cells. In conclusion, the excellent antioxidant and non-mutagenic activities of cashew nut shell liquid (CNSL) provide opportunities for CNSL in the cosmetic and/or pharmaceutical industries, but continuous study is needed to allow safe and efficacious preparations.

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Protection of Saccharomyces cerevisiae against Oxidative and Radiation-Caused Damage by Alkylhydroxybenzenes

Cited by 16 publications

References 9 publications

Alkylresorcinols Protect the DNA from UV-Damage In Vitro and In Vivo Models

Alkylresorcinols Protect the DNA from UV-Damage In Vitro and In Vivo Models

Net effects of cashew nuts in Saccharomyces cerevisiae front to damage induced by hydrogen peroxide

Pharmacological properties of cashew (Anacardium occidentale)

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