Protection of Resveratrol Against Nephrotoxicity in Rats Produced by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin

Abstract

E CONDUCTED A STUDY to examine the impact of Resveratrol (RES) on the renal tissues of Wistar rats that were exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and developed kidney damage. Applied on albino male rats (102), the age range ( 8-9 ) weeks and the weight range (80 -90) gms, (32) rats were used for acute stage of toxicity, while others (70 ) rats were involved as a chronic toxicity; the experiment design consists of 7 groups ; G1 (control -ve), G2 vehicle ( acetone + corn oil), G3 TCDD ( 4 µg/kg b. w.), G4 TCDD ( 2 µg/kg b. w.), G5 (RES), G6 (TCDD ( 4 µg/kg b. w.)+ RES),G (TCDD( 4 µg/kg b. w.) + RES). We found that malondialdehyde (MDA), urea and creatinine levels in the groups treated with TCDD showed significant increases compared to the other groups, despite a decrease in the levels of reduced glutathione (GSH) and catalase (CAT) in the TCDD groups. Comparing to the other groups, we observed a rise in GSH and CAT levels, as well as a decrease in MDA, urea, and creatinine levels in the RES treated group. The administration of RES improved the oxidative stress markers and histological alterations caused by TCDD.