Protection of mice against <i>Plasmodium berghei</i> infection by a tuftsin derivative

Gupta, C. M.; Puri, Anju; Jain, Rakesh; Bali, Anu; Anand, Nitya

doi:10.1016/0014-5793(86)80927-9

Cited by 32 publications

(14 citation statements)

References 8 publications

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“…Tuftsin potentiates the natural killer activity of the macrophages and other phagocytosing cells and has been shown to enhance the nonspecific resistance of the host against parasitic and fungal infections (4,6,12). However, in the present study the immunoprophylactic treatment with Tuft-Lip did not prove very effective against tuberculosis infections.…”

Section: Discussioncontrasting

confidence: 72%

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Tuftsin-bearing liposomes as rifampin vehicles in treatment of tuberculosis in mice

Agarwal

Kandpal

Gupta

et al. 1994

Antimicrob Agents Chemother

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The antitubercular activity of rifampin was considerably increased when it was encapsulated in egg phosphatidylcholine liposomes. A further increase in the activity was observed when the macrophage activator tetrapeptide tuftsin was grafted on the surface of the drug-loaded liposomes. Intermittent treatments (twice weekly) with these preparations were significantly more effective than the continuous treatments. Rifampin delivered twice weekly for 2 weeks in tuftsin-bearing liposomes was at least 2,000 times more effective than the free drug in lowering the load of lung bacilli in infected animals. However, pretreatment with drug-free tuftsin-bearing liposomes did not render the pretreated animals resistant to the Mycobacterium tuberculosis infections, neither did it appreciably increase the chemotherapeutic efficacy of the liposomized rifampin. These results clearly demonstrate that liposome targeting to macrophages could considerably increase the antitubercular activity of liposomized drugs such as rifampin. Also, it shows that immunoprophylactic treatment with macrophage activators such as tuftsin does not afford any advantage in treatment of tuberculosis infections,

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Section: Discussioncontrasting

confidence: 72%

“…The liposomes thus formed have been shown to be quite effective as drug vehicles in treatment of leishmaniasis (6) and aspergillosis (12). Also, pretreatment of animals with these liposomes has been found to render them resistant to a variety of infections (4,6,12 …”

mentioning

confidence: 99%

Tuftsin-bearing liposomes as rifampin vehicles in treatment of tuberculosis in mice

Agarwal

Kandpal

Gupta

et al. 1994

Antimicrob Agents Chemother

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“…Egg phosphatidylcholine (egg PC) was isolated and purified as described earlier [20]. Tuftsin modified at the C‐terminus was prepared as described earlier [21]. Nystatin and Amp B were purchased from Sigma Chemical Co. Fungizone was procured from Sarabhai Chemicals (Baroda, India).…”

Section: Methodsmentioning

confidence: 99%

Co-administration of immunomodulator tuftsin and liposomised nystatin can combat less susceptibleCandida albicansinfection in temporarily neutropenic mice

Khan¹,

Nasti²,

Khanam³

et al. 2004

FEMS Immunology &Amp; Medical Microbiology

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In order to develop a prospective chemotherapeutic agent against opportunistic infections, it is important to know that host factors such as degree of immunological debility as well as recovery of immune functions to normality may contribute significantly to a successful elimination of the pathogens. We demonstrated previously that concomitant delivery of antimicrobial agents and immunomodulators to the pathogen harbouring-host contributes to the complete elimination of the deep-seated fungal infections (aspergillosis and candidiasis) in animals with normal immune status. Considering that neutropenic hosts are the main targets of such infections, it can be argued about the potential of the immunomodulator-based therapy in subjects with non-functional immune system. To resolve the hypothesis, we studied the role of immunomodulator tuftsin against experimental murine candidiasis in temporarily neutropenic Balb/c mice. The neutropenic mice were challenged with an isolate of Candida albicans that was showing less susceptibility to both free and liposomised-amphotericin B. The co-administration of tuftsin increased the efficiency of liposomised-polyene antibiotics (nystatin and amphotericin B) against experimental murine candidiasis in immunocompromised Balb/c mice. Pretreatment with liposomised tuftsin prior to C. albicans infection clearly enhanced protection against candidiasis, suggesting a prophylactic role of tuftsin in normal and temporarily neutropenic animals.

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“…Treatment of macrophages with these liposomes considerably increases their respiratory burst activity (Singh et al 1992). Pretreatment of animals with tuftsin-bearing liposomes enables them to resist malaria (Gupta et al 1986); leishmania (Guru et al 1989); antifungal (Owais et al 1993), and antifilarial drugs in liposomes containing palmitoyl tuftsin is shown to increase the therapeutic efficacy of drugs against these infections. Gupta and Haq (2005) described procedures for preparation of I as well as the liposomes that contain I in their bilayers, entrapment of various drugs in these liposomes, and their delivery to experimental animals with infected L. donovani, M. tuberculosis, or Aspergillus.…”

Section: Tuftsin: a Highly Effective Immunomodulatormentioning

confidence: 99%