Protection of goats against rinderpest by vaccination with attenuated peste des petits ruminants virus

Couacy‐Hymann, Emmanuel; Kebkiba, Bidjeh; Angba, Assy; Doménech, Joseph; Diallo, Adama

doi:10.1016/0034-5288(95)90041-1

Cited by 43 publications

(26 citation statements)

References 12 publications

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“…The vaccinated animals did not develop any disease following challenge with virulent PPRV strains and thereby this vaccine was used worldwide (Africa, Middle East and Sothern Asia) for effective control of PPR. In a cross protection study, PPR vaccine was found to protect cattle effectively against RP [34]. It has been demonstrated that freeze-drying of this vaccine in an excipient containing trehalose makes it very thermostable and it resists temperature up to 45°C for a period of 14 days with minimal loss of potency [159].…”

Section: Prevention and Controlmentioning

confidence: 99%

Diagnosis and control of peste des petits ruminants: a comprehensive review

Balamurugan¹,

Hemadri²,

Gajendragad³

et al. 2013

VirusDis.

130

118

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Peste des petits ruminants (PPR) is an acute, highly contagious, world organization for animal health (OIE) notifiable and economically important transboundary viral disease of sheep and goats associated with high morbidity and mortality and caused by PPR virus. PPR is considered as one of the main constraints in augmenting the productivity of small ruminants in developing countries and particularly severely affects poor farmer's economy. The disease is clinically manifested by pyrexia, oculo-nasal discharges, necrotizing and erosive stomatitis, gastroenteritis, diarrhoea and bronchopneumonia. The disease can be diagnosed from its clinical signs, pathological lesions, and specific detection of virus antigen/antibodies/genome in the clinical samples by various serological tests and molecular assays. PPR is the one of the priority animal diseases whose control is considered important for poverty alleviation in enzootic countries. Availability of effective and safe live attenuated cell culture PPR vaccines and diagnostics have boosted the recently launched centrally sponsored control programme in India and also in other countries. This review article primarily focus on the current scenario of PPR diagnosis and its control programme with advancement of research areas that have taken place in the recent years with future perspectives.

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Section: Prevention and Controlmentioning

confidence: 99%

Diagnosis and control of peste des petits ruminants: a comprehensive review

Balamurugan¹,

Hemadri²,

Gajendragad³

et al. 2013

VirusDis.

130

118

View full text Add to dashboard Cite

show abstract

“…The disease affects both goats and sheep; however, goats are considered more susceptible than sheep (Gargadennac and Lalanne 1942). The disease is associated with high mortality and morbidity rates in naïve populations (Kaukarbayevich 2009), colossal economic losses (Couacy-Hymann et al 1995), reduced production, productivity as well as high control costs (FAO 2010). PPR negatively affects livelihoods through diminished and complete loss of incomes and increased vulnerability to shocks as reported during the PPR outbreak in Kenya (FAO 2009a, b).…”

Section: Introductionmentioning

confidence: 99%

Sero-prevalence study to determine the effectiveness of Peste de Petits Ruminants vaccination in Somalia

Njue

Saeed

Maloo³

et al. 2018

Pastoralism

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Peste de Petits Ruminants (PPR) is an acute or sub-acute highly contagious viral disease of small ruminants caused by morbillivirus and associated with high mortality and morbidity rates in naïve populations, colossal economic losses, reduced production and productivity as well as high control costs. Sero-surveys conducted in Somalia between 2006 and 2009 revealed sero-prevalence of 6.5% in north-western Somalia, 28.7% in north-eastern Somalia, 32.6% in central Somalia and 37.6% in southern Somalia. Somalia, like other countries in conflict, has limited capacity to control PPR. In this regard, Food and Agriculture Organisation of the United Nations (FAO) conducted country-wide PPR vaccination campaigns covering the five zones of Somalia, namely, Banadir, central, north-eastern, north-western and southern using a public-private partnership approach. Approximately 20 million sheep and goats constituting 60% of the estimated Somalia national small ruminant population were targeted for vaccination in entire Somalia in 2012. Data on vaccination was captured using FAO's Form Monitoring Tool (FMT) software. The overall unit cost of PPR vaccination was estimated to be USD 0.28 per animal. Two serological surveys were conducted before and after the vaccination campaigns where a two-stage cluster sampling methodology was used to collect sera samples for analysis. The results showed an overall increase in individual animal sero-prevalence from 62 to 76% after PPR vaccination campaign. This paper primarily focuses on practicality of PPR control in Somalia, a conflict-affected and fragile zone, which can be adopted by other countries.

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“…RP is currently the target of an international eradication campaign (20). Sheep and goats can be infected with RPV, but only the most virulent strains show any clinical disease in these species (7,16). Because of the cross-reactive and cross-protective antibodies generated by either of these two related viruses, the normal tissue cultureadapted vaccine strain of RPV (RBOK) (37) is commonly used to vaccinate against PPR, as it is known to be both safe and clinically effective (47).…”

mentioning

confidence: 99%

Recovery and Characterization of a Chimeric Rinderpest Virus with the Glycoproteins of Peste-des-Petits-Ruminants Virus: Homologous F and H Proteins Are Required for Virus Viability

Das

Baron

Barrett

2000

J Virol

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Rinderpest (RP) and peste-des-petits-ruminants (PPR) are two important diseases of domestic ruminants.To improve on currently available vaccines against PPR, we have created cDNA copies of the RP virus genome in which either the fusion (F) or hemagglutinin (H) gene, or both, was replaced with the corresponding gene from PPR virus. It was necessary to develop a modified rescue system in which the T7 RNA polymerase was provided by a recombinant fowlpox virus and the entire rescue procedure took place in Vero cells before we could obtain live virus from these chimeric constructs. No virus was recovered when only one of the glycoprotein genes was changed, but a chimeric virus containing both F and H genes from PPR virus was reproducibly rescued from cDNA, indicating that a virus-specific functional interaction takes place between the F and H proteins. The rescued virus expressing the PPR glycoproteins grew more slowly in tissue culture than either parental virus and formed abnormally large syncytia. Goats infected with the chimera showed no adverse reaction, as assessed by clinical signs, temperature, leukocyte count, virus isolation, and serology, and were protected from subsequent challenge with wild-type PPR virus.

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Protection of goats against rinderpest by vaccination with attenuated peste des petits ruminants virus

Cited by 43 publications

References 12 publications

Diagnosis and control of peste des petits ruminants: a comprehensive review

Diagnosis and control of peste des petits ruminants: a comprehensive review

Sero-prevalence study to determine the effectiveness of Peste de Petits Ruminants vaccination in Somalia

Recovery and Characterization of a Chimeric Rinderpest Virus with the Glycoproteins of Peste-des-Petits-Ruminants Virus: Homologous F and H Proteins Are Required for Virus Viability

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