Protection of force incentive on bone lose of tail-suspended rats

Abstract

7-week-old male Wistar rats were randomly divided into 3 groups. One group was suspended by tail for 21 days, one groups were suspended for 21 days and play 1 minutes/day of force incentive (2N, 10 Hz), one group served as control. bone mass, biomechanical properties, histomorphometry and biochemical marked were determined. Results Short-time force incentive not only can improve the metabolism of calcium and phosphorus as well as histomorphometry of tibia, but also can increase bone mineral, biomechanical properties and decrease the content of NO in femur. Conclusion Short-time force incentive can protect the bone lose in stimulated microgravity. Compare with the traditional methods such as using drug, the physical methods, for example, short-time force incentive are less vehement and more safety, which can maintain the normal structure of bone. So short-time force incentive maybe can develop to the primary protective method on osteoporosis.