Protection of Flos Lonicerae against acetaminophen-induced liver injury and its mechanism

Jiang, Ping; Sheng, Yuchen; Chen, Yuhao; Ji, Lili; Wang, Zhengtao

doi:10.1016/j.etap.2014.10.019

Cited by 25 publications

(13 citation statements)

References 37 publications

(38 reference statements)

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“…At the moment, N-acetylcysteine, the precursor of cellular GSH synthesis, is the only clinical antidote for APAP-induced hepatotoxicity [8,9] . There has been sustained interest in the antioxidant and health benefits of phytochemicals in plants due to increasing realization that herbs can influence the course of diseases and their treatment and that bioactive phytochemicals in plant might provide effective, safe, and cheap therapy [16] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of homopterocarpin, an isoflavonoid from Pterocarpus erinaceus, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity

Akinmoladun

Olaleye

Komolafe

et al. 2015

Journal of Basic and Clinical Physiology and Pharmacology

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Section: Introductionmentioning

confidence: 99%

“…It is a major cause of liver failure and causes death when taken in excess [8,9] . APAP is rapidly absorbed from the stomach and small intestine and metabolized by the conjugation in the liver to non-toxic agents.…”

Section: Introductionmentioning

confidence: 99%

Effect of homopterocarpin, an isoflavonoid from Pterocarpus erinaceus, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity

Akinmoladun

Olaleye

Komolafe

et al. 2015

Journal of Basic and Clinical Physiology and Pharmacology

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“…Because of their high contents and wide pharmacological efficacies, these compounds have been considered as chemical markers in the quality control. Anti‐inflammatory, antibacterial, antioxidant and many other pharmacological effects have been reported for these compounds (Han et al, ; Ji et al, ; Jiang, Sheng, Chen, Ji, & Wang, ; Wu et al, ). However, one critical concern is that the systemic bioavailability for most of these compounds is low.…”

Section: Introductionmentioning

confidence: 99%

Characterization of isochlorogenic acid A metabolites in rats using high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry

Wang

Cao

Wang

et al. 2017

Biomedical Chromatography

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Isochlorogenic acid A is widely present in fruits, vegetables and herbal medicines, and is characterized by anti-inflammatory, hepatoprotective and antiviral properties. However, little is known about its metabolic fate and pharmacokinetic properties. This study is thus designed to investigate the metabolic fate of isochlorogenic acid A. An analytical method based on high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF MS) was established to characterize the metabolites of isochlorogenic acid A in the plasma, urine and feces of rats. A total of 32 metabolites were identified. The metabolic pathways mainly include hydrolyzation, dehydroxylation, hydrogenation and conjugation with methyl, glucuronic acid, glycine, sulfate, glutathione and cysteine. Moreover, the pharmacokinetic profiles of all the circulating metabolites were investigated. M11 resulting from hydrolyzation, dehydroxylation and hydrogenation was the dominant circulating metabolite after the intragastric administration of isochlorogenic acid A. The results obtained will be useful for further study of elucidating potential bioactive metabolites which can provide better explanation of the pharmacological and/or toxicological effects of this compound.

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“…Use of LJF was first recorded in Shen-Nong's Herbals, one of the world's earliest pharmacopeias, and it has been widely used throughout China for disease prevention and treatment. Specifically, LJF has a variety of bioactive effects, including antibacterial, anti-inflammatory (Tae et al, 2003 ), and antiviral properties as well as liver protection activity (Jiang et al, 2014 ). LJF is officially listed in the 2015 version of the Chinese pharmacopeia, where it is listed simultaneously with Lonicerae Flos (LF, Shanyinhua in Chinese).…”

Section: Introductionmentioning

confidence: 99%

Spectrum-Effect Relationships Between Chemical Fingerprints and Antibacterial Effects of Lonicerae Japonicae Flos and Lonicerae Flos Base on UPLC and Microcalorimetry

Shi

Liu

et al. 2016

Front. Pharmacol.

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The traditional Chinese medicines Lonicerae Japonicae Flos (LJF, Jinyinhua in Chinese) and Lonicerae Flos (LF, Shanyinhua in Chinese) refer to the flower buds of five plants belonging to the Caprifoliaceae family. Until 2000, all of these were officially listed as a single item, LJF (Jinyinhua), in the Chinese Pharmacopoeia. However, there have recently been many academic controversies concerning the separation and combination of LJF and LF in administrative regulation. Till now there has been little work completed evaluating the relationships between biological activity and chemical properties among these drugs. Microcalorimetry and UPLC were used along with principal component analysis (PCA), hierarchical cluster analysis (HCA), and canonical correlation analysis (CCA) to investigate the relationships between the chemical ingredients and the antibacterial effects of LJF and LF. Using multivariate statistical analysis, LJF and LF could be initially separated according to their chemical fingerprints, and the antibacterial effects of the two herbal drugs were divided into two clusters. This result supports the disaggregation of LJF and LF by the Pharmacopoeia Committee. However, the sample of Lonicera fulvotomentosa Hsu et S. C. Cheng turned out to be an intermediate species, with similar antibacterial efficacy as LJF. The results of CCA indicated that chlorogenic acid and 3,4-Dicaffeoylquinic acid were the major components generating antibacterial effects. Furthermore, 3,4-Dicaffeoylquinic acid could be used as a new marker ingredient for quality control of LJF and LF.

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Protection of Flos Lonicerae against acetaminophen-induced liver injury and its mechanism

Cited by 25 publications

References 37 publications

Effect of homopterocarpin, an isoflavonoid from Pterocarpus erinaceus, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity

Effect of homopterocarpin, an isoflavonoid from Pterocarpus erinaceus, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity

Characterization of isochlorogenic acid A metabolites in rats using high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry

Spectrum-Effect Relationships Between Chemical Fingerprints and Antibacterial Effects of Lonicerae Japonicae Flos and Lonicerae Flos Base on UPLC and Microcalorimetry

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