Protection of chickens against renal damage caused by a nephropathogenic infectious bronchitis virus

Cook, Jane K.A.; Chesher, J.; Baxendale, W.; Greenwood, N.M.; Huggins, M. B.; Orbell, S. J.

doi:10.1080/03079450120066421

Cited by 78 publications

(75 citation statements)

References 17 publications

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“…Some IBV strains are intrinsically nephropathogenic i.e. they reproducibly cause nephritis when inoculated experimentally into specific pathogen free chickens, causing mortality [30,63,64,81]. IBV infects mainly the lower nephron down to the collecting duct epithelial cells [25,26].…”

Section: Pathogenesis Of Ibvmentioning

confidence: 99%

Coronavirus avian infectious bronchitis virus

2007

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-Infectious bronchitis virus (IBV), the coronavirus of the chicken (Gallus gallus), is one of the foremost causes of economic loss within the poultry industry, affecting the performance of both meat-type and egg-laying birds. The virus replicates not only in the epithelium of upper and lower respiratory tract tissues, but also in many tissues along the alimentary tract and elsewhere e.g. kidney, oviduct and testes. It can be detected in both respiratory and faecal material. There is increasing evidence that IBV can infect species of bird other than the chicken. Interestingly breeds of chicken vary with respect to the severity of infection with IBV, which may be related to the immune response. Probably the major reason for the high profile of IBV is the existence of a very large number of serotypes. Both live and inactivated IB vaccines are used extensively, the latter requiring priming by the former. Their effectiveness is diminished by poor cross-protection. The nature of the protective immune response to IBV is poorly understood. What is known is that the surface spike protein, indeed the amino-terminal S1 half, is sufficient to induce good protective immunity. There is increasing evidence that only a few amino acid differences amongst S proteins are sufficient to have a detrimental impact on cross-protection. Experimental vector IB vaccines and genetically manipulated IBVs -with heterologous spike protein genes -have produced promising results, including in the context of in ovo vaccination.

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Section: Pathogenesis Of Ibvmentioning

confidence: 99%

Coronavirus avian infectious bronchitis virus

2007

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“…Extensive clinical experience and laboratory studies have shown that vaccination with two or more different live attenuated IBV vaccines confers a broad protection against many important heterologous serotypes (Cook et al, 1999(Cook et al, , 2001Worthington et al, 2004). This has led to the ''protectotype'' concept, according to which significant cross-protection can be obtained by using strains that are dominant antigenically.…”

Section: Introductionmentioning

confidence: 99%

Pathogenicity of a QX strain of infectious bronchitis virus in specific pathogen free and commercial broiler chickens, and evaluation of protection induced by a vaccination programme based on the Ma5 and 4/91 serotypes

et al. 2008

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The aims of this study were firstly to evaluate the pathogenicity of an Italian isolate of the QX strain of infectious bronchitis (IB) virus using 1-day-old female specific pathogen free chicks (layer type) and 1-dayold female commercial broiler type chickens, and secondly to assess the level of protection induced in these birds by a vaccination programme including the IB Massachusetts and 4/91 serotype live attenuated vaccines. Unvaccinated birds showed clinical signs of varying severity, predominantly affecting the upper respiratory tract. Vaccinated birds appeared healthy, with the exception of a very mild conjunctivitis affecting a limited number of the broilers. Vaccination fully protected specific pathogen free birds, since no histopathological lesions were observed, nor was virus detected following challenge. In broilers, replication of the challenge virus was not prevented but was significantly reduced. This study confirms that vaccination at 1 day old and at 14 days of age using the Ma5 and 4/91 IB vaccines may be instrumental in reducing the economic impact of QX IB virus infections in layer and broiler farms.

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“…Although these recent papers give us a valuable insight into the genetic epidemiology of IBV in Brazil, they lack data concerning serotyping, pathotyping and protection provided by vaccination against the recent Brazilian IBV strains. It has been shown in several papers reporting the level of homology of the S1 gene (or a part of it) and the level of cross-protection that there is on average a higher chance of a good level of cross-protection between strains with a high level of homology than between strains with low homology (Cavanagh et al, 1997;Cook et al, 2001;Meir et al, 2004;Gelb et al, 2005;Ladman et al, 2006). However, all data together show that this relationship is rather weak (De Wit et al, 2011a).…”

Section: Introductionmentioning

confidence: 55%

Increased level of protection of respiratory tract and kidney by combining different infectious bronchitis virus vaccines against challenge with nephropathogenic Brazilian genotype subcluster 4 strains

et al. 2015

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Genotyping of seven infectious bronchitis virus (IBV) strains isolated in Brazil showed that all belonged to the common Brazilian genotype and that these strains were closest to the subcluster of strain IBV/Brazil/2007/USP-19. Pathotyping of four selected Brazilian strains showed that they all caused a considerable level of ciliostasis in the trachea but at a somewhat lower level than did M41 and Brazilian strains 50/96, 57/96, 62/96 and 64/96 representing four different serotypes that had been reported earlier. In contrast to the M41 challenge strain, all Brazilian isolates replicated in kidney tissue in a high percentage of non-vaccinated challenged birds, clearly showing that they are nephropathogenic. As for the tracheal protection, the results using Massachusetts (Mass) vaccination against the recent strains seemed to show protection higher on average than for the strains reported earlier. A single or twofold vaccination with a Mass vaccine resulted in a mean tracheal protection level against the four challenge strains of 92% and 90%, respectively, whereas a single and twofold vaccination with a Mass vaccine halved the percentage of infected kidneys (14% and 13%, respectively, P < .05) compared to that of the unvaccinated birds (27%). The combination of the Mass and the 793B vaccine provided on average a tracheal protection of 99% and a reduction of the percentage of infected kidneys to a mean of 2%. This was a significantly (P < .05) higher protection than that achieved by a single or twofold Mass vaccination, showing the added value of the 793B vaccination following priming with a vaccine of the Mass type.

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Protection of chickens against renal damage caused by a nephropathogenic infectious bronchitis virus

Cited by 78 publications

References 17 publications

Coronavirus avian infectious bronchitis virus

Coronavirus avian infectious bronchitis virus

Pathogenicity of a QX strain of infectious bronchitis virus in specific pathogen free and commercial broiler chickens, and evaluation of protection induced by a vaccination programme based on the Ma5 and 4/91 serotypes

Increased level of protection of respiratory tract and kidney by combining different infectious bronchitis virus vaccines against challenge with nephropathogenic Brazilian genotype subcluster 4 strains

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