Protection of Cattle Against Rinderpest with Vaccinia Virus Recombinants Expressing the HA or F Gene

Yilma, Tilahun; Hsu, David S.; Jones, Leslie A.; Owens, Sally; Grubman, Marvin J.; Mebus, Charles A.; Yamanaka, Miles; Dale, Beverly A.

doi:10.1126/science.3194758

Cited by 134 publications

(64 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the F protein can be the target of neutralizing antibodies (13), most of the protective immunity to MV is directed against the H protein (4). Similarly, the neutralizing antibodies have been induced with much higher titers in cattle by immunization with vaccinia virus recombinant encoding the H protein of RPV (RPV-H) than with that encoding the F protein (21). The B-cell epitopes on the H protein of MV (MV-H) have been analyzed by several groups by using monoclonal antibodies (MAbs) and synthetic peptides.…”

mentioning

confidence: 99%

Identification of Immunodominant Neutralizing Epitopes on the Hemagglutinin Protein of Rinderpest Virus

Sugiyama

Ito

Minamoto

et al. 2002

J Virol

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Identification of Immunodominant Neutralizing Epitopes on the Hemagglutinin Protein of Rinderpest Virus

Sugiyama

Ito

Minamoto

et al. 2002

J Virol

View full text Add to dashboard Cite

show abstract

“…Recombinant vaccinia viruses have been widely assessed for use as vaccine vectors in several species and have been shown to give rise to protective cytotoxic T cell responses (9). Indeed, a recent report has shown that recombinant vaccinia viruses incorporating the fusion protein or haemagglutinin genes of rinderpest virus induce serum neutralising antibody titres which protect cattle against challenge with the virus (82). Successful use of herpes viruses and adenoviruses as antigen delivery vehicles has also been reported in some species (35).…”

Section: Discussionmentioning

confidence: 99%

Theileria parva : the nature of the immune response and its significance for immunoprophylaxis

McKeever¹,

Morrison²

1990

Rev. Sci. Tech. OIE

View full text Add to dashboard Cite

Summary: Theileria parva is a tick-borne haemoprotozoan parasite of cattle and buffalo which is responsible for considerable economic losses to cattle farming in Eastern, Central and Southern Africa. Infection with the parasite results in an acute lymphoproliferative disorder with high mortality, but animals which survive infection are solidly immune to homologous challenge. Such immunity can be reproduced by infecting cattle with the parasite and treating them with tetracyclines or theilericidal drugs, but the widespread use of this technique as a method of control is hindered by its dependence on live parasites which require cryopreservation for maintenance and can give rise to carrier States. In addition, cross-protection between different strains of the parasite is not absolute. These problems have prompted a search for methods of immunisation based on the use of inactivated parasites or their derivatives. Such efforts have met with consistent failure, however, and in recent years scientists have adopted the more rational approach of defining the immune responses of cattle to the parasite with a view to identifying the parasite components which provoke them. These studies have revealed that protection is likely to be mediated by parasitespecific cytotoxic T cells which are restricted by class I major histocompatibility complex (MHC) products. The significance of this observation to the development of an effective subunit vaccine is discussed in the light of current knowledge of the inductive requirements of cytotoxic T cells.KEYWORDS: Antibody -Antigen -Antigen delivery -Antigen processingCell-mediated immunity -Cross-protection -Immunisation -Immunity -MHCrestriction -Parasite -Pathology -Theileria -Vaccine. THE PARASITE AND ITS LIFE CYCLETheileria parva is a haemoprotozoan parasite which infects cattle and buffalo in large areas of Eastern, Central and Southern Africa. The sporozoite stage of the parasite is transmitted by the three-host tick Rhipicephalus appendiculatus and invades lymphocytes, where its development to the schizont stage is associated with uncontrolled proliferation of the cell. The capacity of the parasite to associate with the mitotic spindle (78) ensures that schizonts are passed on to successive generations of daughter cells, giving rise to a clonal expansion of the initially parasitised population. A proportion of parasitised cells undergo merogony, resulting in disruption of the lymphocyte and release of merozoites into the blood. Merozoites then invade erythrocytes and differentiate into piroplasms which constitute the infective stage for the tick. PATHOGENESISInfection of cattle with T. parva gives rise to an acute lymphoproliferative disorder known as East Coast fever (ECF), and the course of this disease has been well characterised in experimentally-infected animals (47). At approximately 8 days after infection, schizont-infected cells are detectable in the lymph node which drains the site of inoculation. Parasitised cells can be detected in other lymphoid tissues throughout th...

show abstract

“…However, only two have been used in large-scale field trials. One is a recombinant rinderpest vaccine which has been tested in Africa and India [14]. The other is the recombinant rabies vaccine used for oral immunization of wild foxes, the major reservoir of rabies in Western Europe.…”

Section: Poxvirus Recombinant Vaccinesmentioning

confidence: 99%

The Jenner bicentenary; still uses for smallpox vaccine

Baxby

1996

Epidemiol. Infect.

View full text Add to dashboard Cite

show abstract

Protection of Cattle Against Rinderpest with Vaccinia Virus Recombinants Expressing the HA or F Gene

Cited by 134 publications

References 17 publications

Identification of Immunodominant Neutralizing Epitopes on the Hemagglutinin Protein of Rinderpest Virus

Identification of Immunodominant Neutralizing Epitopes on the Hemagglutinin Protein of Rinderpest Virus

Theileria parva : the nature of the immune response and its significance for immunoprophylaxis

The Jenner bicentenary; still uses for smallpox vaccine

Contact Info

Product

Resources

About