Protection of Acid–Base Balance by pH Regulation of Acid Production

Hood, Virginia L.; Tannen, Richard L.

doi:10.1056/nejm199809173391207

Cited by 146 publications

(72 citation statements)

References 53 publications

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“…Lactate infusion can disturb the acid-base balance (Hood and Tannen, 1998) and cerebral blood flow (CBF). High lactate may initially cause a low blood pH, followed by an alkalization (Gladden and Yates, 1983).…”

Section: Some Methodologic Aspectsmentioning

confidence: 99%

Modeling Cerebral Arteriovenous Lactate Kinetics after Intravenous Lactate Infusion in the Rat

Leegsma-Vogt

Werf

Venema

et al. 2004

J Cereb Blood Flow Metab

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Summary: Venous-arterial lactate differences across the brain during lactate infusion in rats were studied, and the fate of lactate was described with a mathematical model that includes both cerebral and extracerebral kinetics. Ultrafiltration was used to sample continuously and simultaneously arterial and venous blood. Subsequent application of flow injection analysis and biosensors allowed the measurement of glucose and lactate concentrations every minute. Because of the high temporal resolution, arteriovenous lactate kinetics could be modeled in individual experiments. The existence of both a cerebral lactate sink and a lactate exchangeable compartment, representing approximately 24% of brain volume, was thus modeled.

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Section: Some Methodologic Aspectsmentioning

confidence: 99%

Modeling Cerebral Arteriovenous Lactate Kinetics after Intravenous Lactate Infusion in the Rat

Leegsma-Vogt

Werf

Venema

et al. 2004

J Cereb Blood Flow Metab

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“…254 tabolism in mammals (Székely, 2000), adaptive daytime hypothermia in nocturnal mammals (Kanizsai et al, 2009), or nutrition-dependent nocturnal hypothermia in birds (Geran and Rashotte, 1997). By activating TRPV1 channels, the luminal pH, which fluctuates through the feeding cycle (McConnell et al, 2008) and decreases during prolonged fasting (Hood and Tannen, 1998), may contribute to the hypothermic response to fasting. Indeed, fasting-induced hypothermia was found to be attenuated in Trpv1 KO mice (Kanizsai et al, 2009).…”

Section: Physiological and Pathological Significancementioning

confidence: 99%

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

et al. 2009

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“…An alkaline shift in intracellular pH is known to have a powerful disinhibiting effect on phosphofructokinase, a key, rate-limiting enzyme of glycolysis (Trivedi and Danforth, 1966). Alkalosis leads to increased lactate production both systemically and in the brain (Dager et al, 1995;Hood and Tannen, 1998;Maddock, 2001). Both human and animal studies have shown that the increase in serum lactate during respiratory alkalosis is significantly greater during mild hyperglycemia than during a normoglycemic, fasting state (Brautbar et al, 1983;Maddock and Mateo-Bermudez, 1990).…”

Section: Introductionmentioning

confidence: 99%

Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: A proton magnetic resonance spectroscopy study at 1.5 Tesla

Maddock¹,

Buonocore²,

Lavoie³

et al. 2006

Psychiatry Research: Neuroimaging

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Proton magnetic resonance spectroscopy (1H-MRS) studies showing increased lactate during neural activation support a broader role for lactate in brain energy metabolism than was traditionally recognized. 1H-MRS measures of brain lactate responses have been used to study regional brain metabolism in clinical populations. This study examined whether variations in blood glucose influence the lactate response to visual stimulation in the visual cortex. Six subjects were scanned twice, receiving either saline or 21% glucose intravenously. Using 1H-MRS at 1.5 Tesla with a long echo time (TE=288 msec), the lactate doublet was visible at 1.32 ppm in the visual cortex of all subjects. Lactate increased significantly from resting to visual stimulation. Hyperglycemia had no effect on this increase. The order of the slice-selective gradients for defining the spectroscopy voxel had a pronounced effect on the extent of contamination by signal originating outside the voxel. The results of this preliminary study demonstrate a method for observing a consistent activity-stimulated increase in brain lactate at 1.5 Tesla and show that variations in blood glucose across the normal range have little effect on this response.

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Protection of Acid–Base Balance by pH Regulation of Acid Production

Cited by 146 publications

References 53 publications

Modeling Cerebral Arteriovenous Lactate Kinetics after Intravenous Lactate Infusion in the Rat

Modeling Cerebral Arteriovenous Lactate Kinetics after Intravenous Lactate Infusion in the Rat

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: A proton magnetic resonance spectroscopy study at 1.5 Tesla

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