Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells

Trinh, Mai Duy Luu; Dinh, Minh-Hiep; Ngo, Dai‐Hung; Tran, Dang-Khoa; Tran, Quoc-Tuan; Vo, Thanh‐Sang

doi:10.1016/j.ijbiomac.2014.01.064

Cited by 13 publications

(5 citation statements)

References 28 publications

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“…From the 1 H-NMR spectra, 4-hydroxybenzyl-CHOS showed peaks at 8-6.9 ppm belonging to the protons of the aromatic ring of 4-hydroxybenzaldehyde along with characteristic peaks of CHOS. Thus, the spectroscopic results elucidated the successful link between 4-hydroxybenzaldehyde and CHOS [63].…”

Section: N-aryl Chosmentioning

confidence: 88%

“…To eliminate the free aldehyde, the dialysate was precipitated in acetone and rinsed with diethyl ether. The final step was to dry the product at room temperature to produce 4-hydroxybenzyl-CHOS [63].…”

Section: N-aryl Chosmentioning

confidence: 99%

“…However, the CHOS-gallic acid conjugate had a more profound anti-inflammatory effect (Table 3) [65]. In Chang liver cells, 4-hydroxybenzyl-CHOS suppressed the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) to diminish NO and prostaglandin E2 (PGE2) synthesis [63]. Additionally, in a dose-dependent manner, 4-hydroxybenzyl-CHOS reduced the activation of mitogen-activated protein kinases (MAPKs), the translocation of nuclear factor-κβ (NF-κβ), and the degradation of inhibitory κβα (Iκβα).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…Delay β-cell apoptosis 3. Improve β-cell function and promote insulin secretion [107] 4-hydroxybenzyl-CHOS Suppress iNOS, COX-2, and MAPK activation and NF-κβ and Iκβα degradation [63] Apple polyphenols-CHOS microcapsule…”

Section: Chos-caffeic Acidmentioning

confidence: 99%

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Chitooligosaccharide and Its Derivatives: Potential Candidates as Food Additives and Bioactive Components

Mittal,

Singh,

Buatong

et al. 2023

Foods

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Chitooligosaccharide (CHOS), a depolymerized chitosan, can be prepared via physical, chemical, and enzymatic hydrolysis, or a combination of these techniques. The superior properties of CHOS have attracted attention as alternative additives or bioactive compounds for various food and biomedical applications. To increase the bioactivities of a CHOS, its derivatives have been prepared via different methods and were characterized using various analytical methods including FTIR and NMR spectroscopy. CHOS derivatives such as carboxylated CHOS, quaternized CHOS, and others showed their potential as potent anti-inflammatory, anti-obesity, neuroprotective, and anti-cancer agents, which could further be used for human health benefits. Moreover, enhanced antibacterial and antioxidant bioactivities, especially for a CHOS-polyphenol conjugate, could play a profound role in shelf-life extension and the safety assurance of perishable foods via the inhibition of spoilage microorganisms and pathogens and lipid oxidation. Also, the effectiveness of CHOS derivatives for shelf-life extension can be augmented when used in combination with other preservative technologies. Therefore, this review provides an overview of the production of a CHOS and its derivatives, as well as their potential applications in food as either additives or nutraceuticals. Furthermore, it revisits recent advancements in translational research and in vivo studies on CHOS and its derivatives in the medical-related field.

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Section: N-aryl Chosmentioning

confidence: 88%

Section: N-aryl Chosmentioning

confidence: 99%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Section: Chos-caffeic Acidmentioning

confidence: 99%

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Chitooligosaccharide and Its Derivatives: Potential Candidates as Food Additives and Bioactive Components

Mittal,

Singh,

Buatong

et al. 2023

Foods

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“…The RAW264.7 cells were incubated with COS or CA‐COS (10–100 μg/mL) for 1 h and added LPS (1 μg/mL) for 24 h while a blank sample was not incubated with both sample and LPS. The NO content in the growth medium for 24 h was determined by the Griess method (Trinh et al., 2014). After 24 h, 50 μL of Griess reagent (1% sulfanilamide and 0.1% naphthyl ethylenediamine dihydrochloride in 2.5% phosphoric acid) was mixed with 50 μL of the culture medium and incubated for 20 min at the room temperature.…”

Section: Methodsmentioning

confidence: 99%

Caffeic acid‐grafted chitooligosaccharides downregulate MAPK and NF‐kB in RAW264.7 cells

Bui,

Vo,

Kim

et al. 2024

Chem Biol Drug Des

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Chitooligosaccharide (COS) is a derivative of chitosan, which is a natural macromolecular compound. COS has been shown effects in an inflammatory response. Recent reports show that COS derivatives have enhanced anti‐inflammatory activity by inhibiting intracellular signals. Evaluation of the anti‐inflammatory effect of caffeic acid conjugated COS chain (CA‐COS) was performed in this study. The effects of CA‐COS on the inflammatory response were demonstrated in lipopolysaccharide‐stimulated RAW264.7 macrophages. The results showed that CA‐COS inhibited nitric oxide (NO) production and downregulated the gene expression of nitric oxide synthase (iNOS), and cytokines such as tumor necrosis factor‐alpha (TNF‐α), IL‐1β, and IL‐6 without cytotoxic effect. In addition, western blot analysis showed that CA‐COS inhibits the protein expression of iNOS and nuclear factor kappa B (NF‐kB), including p50 and p65, and mitogen‐activated protein kinase (MAPK) signaling pathways. Collectively, these results provide clear evidence for the anti‐inflammatory mechanism of CA‐COS that show great potential as a novel agent for the prevention and therapy of inflammatory diseases.

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Chitosan and its Derivatives as Potential Biomaterials

Ngo¹,

Thuong³

et al. 2020

Encyclopedia of Marine Biotechnology

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Protection of 4-hydroxybenzyl-chitooligomers against inflammatory responses in Chang liver cells

Cited by 13 publications

References 28 publications

Chitooligosaccharide and Its Derivatives: Potential Candidates as Food Additives and Bioactive Components

Chitooligosaccharide and Its Derivatives: Potential Candidates as Food Additives and Bioactive Components

Caffeic acid‐grafted chitooligosaccharides downregulate MAPK and NF‐kB in RAW264.7 cells

Chitosan and its Derivatives as Potential Biomaterials

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