Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on 1H NMR metabonomics technology

Yang, Tao; Zhou, Jing; Lei, Fang; Wang, Minmin; Maimaitiyiming, Dilinuer; Aikemu, Ainiwaer

doi:10.1016/j.ab.2021.114342

Cited by 11 publications

(7 citation statements)

References 20 publications

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“…Further, we have identified several different metabolites associated with amino acids altered in this study, which is consistent with a metabolomics study conducted by Yang et al . on rats with hypoxia and high-altitude pulmonary hypertension found significant changes in amino acid metabolism 25 . A study showed that hypoxia is associated with reduced l-arginine transport in normal cells 26 , which can explain our findings that L-arginine metabolism was downregulated in the STR group due to a sudden decrease of oxygen in asphyxial death.…”

Section: Discussionmentioning

confidence: 91%

The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models

Wang,

Liu,

Zhang

et al. 2023

Sci Rep

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This study differentiates myocardial infarction (MI) and strangulation death (STR) from the perspective of amino acid metabolism. In this study, MI mice model via subcutaneous injection of isoproterenol and STR mice model by neck strangulation were constructed, and were randomly divided into control (CON), STR, mild MI (MMI), and severe MI (SMI) groups. The metabolomics profiles were obtained by liquid chromatography-mass spectrometry (LC–MS)-based untargeted metabolomics. Principal component analysis, partial least squares-discriminant analysis, volcano plots, and heatmap were used for discrepancy metabolomics analysis. Pathway enrichment analysis was performed and the expression of proteins related to metabolomics was detected using immunohistochemical and western blot methods. Differential metabolites and metabolite pathways were screened. In addition, we found the expression of PPM1K was significantly reduced in the MI group, but the expression of p-mTOR and p-S6K1 were significantly increased (all P < 0.05), especially in the SMI group (P < 0.01). The expression of Cyt-C was significantly increased in each group compared with the CON group, especially in the STR group (all P < 0.01), and the expression of AMPKα1 was significantly increased in the STR group (all P < 0.01). Our study for the first time revealed significant differences in amino acid metabolism between STR and MI.

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Section: Discussionmentioning

confidence: 91%

The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models

Wang,

Liu,

Zhang

et al. 2023

Sci Rep

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“…Elevated levels of ROS lead to oxidative damage to lipids, proteins, and DNA (Stewart et al, 2018). Recent studies have shown that phytomedicine extracts, such as glycyrrhetinic acid and salidroside, can protect the heart by improving oxidative stress caused by high‐altitude hypoxia (Han et al, 2022; Yang et al, 2021). Previous research has confirmed that excessive oxidative stress occurs at high‐altitude conditions, generating excessive free radicals, resulting in the generation of lipid decomposition products (Bakonyi & Radak, 2004; Chiş et al, 2018; Lüneburg et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Pretreatment with Notoginsenoside R1 attenuates high‐altitude hypoxia‐induced cardiac injury via activation of the ERK1/2‐P90RSK‐Bad signaling pathway in rats

Zhao

Jia

Shen

et al. 2023

Phytotherapy Research

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High‐altitude cardiac injury (HACI) is one of the common tissue injuries caused by high‐altitude hypoxia that may be life threatening. Notoginsenoside R1 (NG‐R1), a major saponin of Panax notoginseng, exerts anti‐oxidative, anti‐inflammatory, and anti‐apoptosis effects, protecting the myocardium from hypoxic injury. This study aimed to investigate the protective effect and molecular mechanism of NG‐R1 against HACI. We simulated a 6000 m environment for 48 h in a hypobaric chamber to create a HACI rat model. Rats were pretreated with NG‐R1 (50, 100 mg/kg) or dexamethasone (4 mg/kg) for 3 days and then placed in the chamber for 48 h. The effect of NG‐R1 was evaluated by changes in Electrocardiogram parameters, histopathology, cardiac biomarkers, oxidative stress and inflammatory indicators, key protein expression, and immunofluorescence. U0126 was used to verify whether the anti‐apoptotic effect of NG‐R1 was related to the activation of ERK pathway. Pretreatment with NG‐R1 can improve abnormal cardiac electrical conduction and alleviate high‐altitude‐induced tachycardia. Similar to dexamethasone, NG‐R1 can improve pathological damage, reduce the levels of cardiac injury biomarkers, oxidative stress, and inflammatory indicators, and down‐regulate the expression of hypoxia‐related proteins HIF‐1α and VEGF. In addition, NG‐R1 reduced cardiomyocyte apoptosis by down‐regulating the expression of apoptotic proteins Bax, cleaved caspase 3, cleaved caspase 9, and cleaved PARP1 and up‐regulating the expression of anti‐apoptotic protein Bcl‐2 through activating the ERK1/2‐P90RSK‐Bad pathway. In conclusion, NG‐R1 prevented HACI and suppressed apoptosis via activation of the ERK1/2‐P90RSK‐Bad pathway, indicating that NG‐R1 has therapeutic potential to treat HACI.

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“…A plateau is an area with an altitude >2500 m, such as the Qinghai-Tibet Plateau, Pamirs, and Bolivian Plateau in South America. [1] With the gradual development of transportation,…”

Section: Introductionmentioning

confidence: 99%

“…A plateau is an area with an altitude >2500 m, such as the Qinghai‐Tibet Plateau, Pamirs, and Bolivian Plateau in South America. [ 1 ] With the gradual development of transportation, international, adventure, and wilderness travelers going to highland areas have increased. [ 2 ] In addition, medical and other industrial staff go to the plateau to work.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Modified Hemoglobin on Rabbits and Goats in High‐Altitude Sickness

Zhu

et al. 2023

Advanced Biology

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The prevalence and severity of high‐altitude sickness increases with increasing altitude. Prevention of hypoxia caused by high‐altitude sickness is an urgent problem. As a novel oxygen‐carrying fluid, modified hemoglobin can carry oxygen in a full oxygen partial pressure environment and release oxygen in a low oxygen partial pressure environment. It is unclear whether modified hemoglobin can improve hypoxic injury on a plateau. Using hypobaric chamber rabbit (5000 m) and plateau goat (3600 m) models, general behavioral scores and vital signs, hemodynamic, vital organ functions, and blood gas are measured. The results show that the general behavioral scores and vital signs decrease significantly in the hypobaric chamber or plateau, and the modified hemoglobin can effectively improve the general behavioral scores and vital signs in rabbits and goats, and reduce the degree of damage to vital organs. Further studies reveal that arterial partial pressure of oxygen (PaO2) and arterial oxygen saturation (SaO2) on the plateau decrease rapidly, and the modified hemoglobin could increase PaO2 and SaO2; thus, increasing the oxygen‐carrying capacity. Moreover, modified hemoglobin has few side effects on hemodynamics and kidney injury. These results indicate that modified hemoglobin has a protective effect against high‐altitude sickness.

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Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on 1H NMR metabonomics technology

Cited by 11 publications

References 20 publications

The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models

The amino acid metabolomics signature of differentiating myocardial infarction from strangulation death in mice models

Pretreatment with Notoginsenoside R1 attenuates high‐altitude hypoxia‐induced cardiac injury via activation of the ERK1/2‐P90RSK‐Bad signaling pathway in rats

Protective Effect of Modified Hemoglobin on Rabbits and Goats in High‐Altitude Sickness

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