Protection from Plasmodium berghei infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human use

Plebanski, Magdalena; Gilbert, Sarah C.; Schneider, Jörg; Hannan, Carolyn M.; Layton, Guy T.; Blanchard, Tom; Becker, Marion; Smith, Geoffrey R.; Butcher, G. A.; Sinden, Robert E.; Hill, Adrian V. S.

doi:10.1002/(sici)1521-4141(199812)28:12<4345::aid-immu4345>3.3.co;2-g

Cited by 37 publications

(54 citation statements)

References 13 publications

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“…[52][53][54] Indeed, MVA, the host restricted modified vaccinia virus Ankara, induced in dendritic cells effects comparable with our VV strain (L Jenne and AW Hü gin, unpublished results).…”

Section: Discussionsupporting

confidence: 64%

Poxvirus as a vector to transduce human dendritic cells for immunotherapy: abortive infection but reduced APC function

et al. 2000

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Section: Discussionsupporting

confidence: 64%

Poxvirus as a vector to transduce human dendritic cells for immunotherapy: abortive infection but reduced APC function

et al. 2000

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“…Several reports have demonstrated that during the hepatic stage of P. berghei infection, responses of CD8 ϩ and of CD4 ϩ T cells conferred protective immunity (33)(34)(35)(36). The role of CD4 ϩ T cells during the blood stage of infection is not completely clear, but many examples demonstrate the importance of CD4 ϩ T cells in the control of blood-stage malaria (1).…”

Section: Discussionmentioning

confidence: 99%

Murine Malaria Is Exacerbated by CTLA-4 Blockade

Jacobs

Graefe

Niknafs

et al. 2002

The Journal of Immunology

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Cytolytic T lymphocyte-associated Ag-4 (CD152) is a negatively regulating molecule, which is primarily expressed on T cells following their activation. In this study, we have examined the role of CTLA-4 expression in experimental blood-stage malaria. Similar to human malaria, CTLA-4 is expressed on CD4+ T cells of C57BL/6 mice after infection with Plasmodium berghei. A kinetic analysis revealed that CTLA-4 expression was increased on day 5 postinfection and reached a peak on day 9 postinfection, when almost 10% of splenic CD4+ T cells expressed CTLA-4. Blockade of CTLA-4 in vivo by a specific mAb and subsequent challenge with P. berghei caused neurological signs reminiscent of murine cerebral malaria and earlier death. Histologic examination of brain sections from anti-CTLA-4-treated mice revealed pathologic changes such as hemorrhages and edema, which were absent in control mice. Furthermore, treatment with anti-CTLA-4 also reversed the extensive loss of CD4+ T cells and the suppressed T cell response occurring during blood-stage malaria. Our data suggest that CTLA-4 expression prevents immune pathology by restricting T cell activation during malaria. They also indicate that the development of cerebral malaria is mediated by a failure to down-regulate T cell activation.

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“…Also using murine malaria as a vaccination model, it has been shown that priming with recombinant virus-like particles derived from a yeast retrotransposon (TyVLPs) containing the P. berghei or P. yoelii CS CD8 epitope could only induce strong CD8 T cell responses and protective immunity to malaria when followed by a booster injection with the recombinant vaccinia virus expressing the P. berghei or P. yoelii CS protein (Table VI and Plebanski et al 1998, Oliveira-Ferreira et al 2000.…”

Section: Malaria Liver Stagesmentioning

confidence: 99%

Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines

Rodrigues

Boscardin

Vasconcelos

et al. 2003

An. Acad. Bras. Ciênc.

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Obligatory intracellular parasites such as Plasmodium sp, Trypanosoma cruzi, Toxoplasma gondii and Leishmania sp are responsible for the infection of hundreds of millions of individuals every year. These parasites can deliver antigens to the host cell cytoplasm that are presented through MHC class I molecules to protective CD8 T cells. The in vivo priming conditions of specific CD8 T cells during natural infection are largely unknown and remain as an area that has been poorly explored. The antiparasitic mechanisms mediated by CD8 T cells include both interferon-γ -dependent and -independent pathways. The fact that CD8 T cells are potent inhibitors of parasitic development prompted many investigators to explore whether induction of these T cells can be a feasible strategy for the development of effective subunit vaccines against these parasitic diseases. Studies performed on experimental models supported the hypothesis that CD8 T cells induced by recombinant viral vectors or DNA vaccines could serve as the basis for human vaccination. Regimens of immunization consisting of two different vectors (heterologous prime-boost) are much more efficient in terms of expansion of protective CD8 T lymphocytes than immunization with a single vector. The results obtained using experimental models have led to clinical vaccination trials that are currently underway.

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Protection from Plasmodium berghei infection by priming and boosting T cells to a single class I-restricted epitope with recombinant carriers suitable for human use

Cited by 37 publications

References 13 publications

Poxvirus as a vector to transduce human dendritic cells for immunotherapy: abortive infection but reduced APC function

Poxvirus as a vector to transduce human dendritic cells for immunotherapy: abortive infection but reduced APC function

Murine Malaria Is Exacerbated by CTLA-4 Blockade

Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines

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