Protection From Ischemic Cell Death by the Induction of Cytoglobin

Stagner, John I.; Parthasarathy, Sairam; Wyler, Karen; Parthasarathy, R.

doi:10.1016/j.transproceed.2005.10.001

Cited by 22 publications

(17 citation statements)

References 5 publications

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“…5, A and B), and both the Vegf mRNA and protein expression levels were regulated by CYGB (Fig. 6), which is consistent with previous findings that CYGB may induce the induction and synthesis of Vegf in vitro (16). We also show that Cygb overexpression increased both the density and diameter of microvessels in brain tissue under HI conditions, due at least in part to the Vegf up-regulation.…”

Section: Discussionsupporting

confidence: 91%

“…Although several previous studies have demonstrated that Cygb is affected by hypoxia in vitro (16,21,42) and in vivo (17,18,20,42,43), the detailed expression patterns of Cygb mRNA and protein in neonatal rats brain suffering from HI have not been reported until now. The present study is the first to undertake a comprehensive analysis of CYGB expression in response to neonatal rat brain HI injury at the acute stage.…”

Section: Discussionmentioning

confidence: 94%

“…The most recently discovered heme protein, androglobin, the fifth member of globin family, is preferentially expressed in the testis and is insensitive to experimental hypoxia (12). The physiological function of CYGB remains unknown, but it is believed to have various roles due to its family homology, such as storing O 2 , facilitating O 2 diffusion, detoxifying reactive oxygen species, acting as an O 2 sensor, and functioning as an NO dioxygenase (5,(13)(14)(15)(16). Thus, CYGB may play a cytoprotective role under hypoxic and/or ischemic conditions.…”

mentioning

confidence: 99%

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Mechanisms of Neuroprotection from Hypoxia-Ischemia (HI) Brain Injury by Up-regulation of Cytoglobin (CYGB) in a Neonatal Rat Model

Tian

Yang

Xiao

et al. 2013

Journal of Biological Chemistry

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Background: Potential functions of cytoglobin (CYGB) in neonatal hypoxia-ischemia (HI) brain injury have not been reported. Results: Up-regulation of CYGB reduces HI injury and improves long term cognitive impairment after neonatal HI. Conclusion: CYGB exhibits neuroprotective effects, possibly through antioxidant and antiapoptotic functions as well as by stimulating angiogenesis. Significance: These results provide a novel target for developing a clinically relevant strategy for future studies.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 99%

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Mechanisms of Neuroprotection from Hypoxia-Ischemia (HI) Brain Injury by Up-regulation of Cytoglobin (CYGB) in a Neonatal Rat Model

Tian

Yang

Xiao

et al. 2013

Journal of Biological Chemistry

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“…Interestingly, Cygb has been shown to have a cytoprotective effect upon exposure to hypoxia or ischaemia. In transplanted b-islet cells undergoing ischaemic injury, Cygb overexpression afforded higher survival, function maintenance and reduced immunorejection [90]. In another study, exogenous overexpression of Cygb supported cell survival, while Cygb silencing augmented cell death in ischaemic conditions [75].…”

Section: Engagement In Cellular Response To Hypoxic Stressmentioning

confidence: 94%

Cytoglobin: biochemical, functional and clinical perspective of the newest member of the globin family

Oleksiewicz

Liloglou

Field

et al. 2011

Cell. Mol. Life Sci.

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Since the discovery of cytoglobin (Cygb) a decade ago, growing amounts of data have been gathered to characterise Cygb biochemistry, functioning and implication in human pathologies. Its molecular roles remain under investigation, but nitric oxide dioxygenase and lipid peroxidase activities have been demonstrated. Cygb expression increases in response to various stress conditions including hypoxia, oxidative stress and fibrotic stimulation. When exogenously overexpressed, Cygb revealed cytoprotection against these factors. Cygb was shown to be upregulated in fibrosis and neurodegenerative disorders and downregulated in multiple cancer types. CYGB was also found within the minimal region of a hereditary tylosis with oesophageal cancer syndrome, and its expression was reduced in tylotic samples. Recently, Cygb has been shown to inhibit cancer cell growth in vitro, thus confirming its suggested tumour suppressor role. This article aims to review the biochemical and functional aspects of Cygb, its involvement in various pathological conditions and potential clinical utility.

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“…Various strategies such as modifications in enzymatic digestion [13] , purification with iodixanol instead of ficoll [14] , incubation of purified islets in culture medium, genetic manipulation for overexpression [15,16] or silencing [17] of specific genes, employment of different anti-inflammator y or other supplements such as small intestinal submucosa [18] and serecin [19] have been considered in an attempt to increase islet quality and yield. In a previous publication we hypothesized that using phototherapy could improve islet function before transplantation [20] .…”

Section: Islet Isolation and Role Of Oxidative Stressmentioning

confidence: 99%

Islet transplantation and antioxidant management: A comprehensive review

Monfared¹,

Larijani

Abdollahi

2009

WJG

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Islet transplantation as a promising treatment for type 1 diabetes has received widespread attention. Oxidative stress plays an essential role in cell injury during islet isolation and transplantation procedures. Antioxidants have been used in various studies to improve islet transplantation procedures. The present study reviews the role of oxidative stress and the benefits of antioxidants in islet transplantation procedures. The bibliographical databases Pubmed and Scopus were searched up to November 2008.All relevant human and animal in-vivo and in-vitro studies, which investigated antioxidants on islets, were included. Almost all the tested antioxidants used in the in-vitro studies enhanced islet viability and insulin secretion. Better control of blood glucose after transplantation was the major outcome of antioxidant therapy in all in-vivo studies. The data also indicated that antioxidants improved islet transplantation procedures. Although there is still insufficient evidence to draw definitive conclusions about the efficacy of individual supplements, the benefits of antioxidants in islet isolation procedures cannot be ignored.

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Protection From Ischemic Cell Death by the Induction of Cytoglobin

Cited by 22 publications

References 5 publications

Mechanisms of Neuroprotection from Hypoxia-Ischemia (HI) Brain Injury by Up-regulation of Cytoglobin (CYGB) in a Neonatal Rat Model

Mechanisms of Neuroprotection from Hypoxia-Ischemia (HI) Brain Injury by Up-regulation of Cytoglobin (CYGB) in a Neonatal Rat Model

Cytoglobin: biochemical, functional and clinical perspective of the newest member of the globin family

Islet transplantation and antioxidant management: A comprehensive review

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