Protection from H1N1 Influenza Virus Infections in Mice by Supplementation with Selenium: A Comparison with Selenium-Deficient Mice

Yu, Long-Chuan; Sun, Lei; Nan, Yi; Zhu, Ling

doi:10.1007/s12011-010-8726-x

Cited by 74 publications

(56 citation statements)

References 25 publications

(24 reference statements)

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“…In our study, the serum level of TNF-α in the Se yeast group is significantly lower than the controls. Likewise, previous study also found that Se supplementation lowers the production of TNF-α in other diseases or infectious models [50,51]. Indeed, TNF-α production in mice alveolar macrophages, which experimentally infected with PCV2, is reported to be higher than the control group [52].…”

Section: Discussionmentioning

confidence: 71%

Effect of Dietary Selenium Yeast Supplementation on Porcine Circovirus Type 2 (PCV2) Infections in Mice

et al. 2015

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The present study was performed to determine the protective role of dietary selenium (Se) yeast supplementation in porcine circovirus type 2 (PCV2) infected mice. Forty-eight Kun Ming female mice were randomly assigned to Se yeast group (0.3%Se +basal diet, n = 24) and control group (basal diet, n = 24). After 3 days of adaptive feeding and 15 days treatment with the experimental feed, mice were challenged by intraperitioneal injection of PCV2 at the dosage of 2000 TCID50 (50% tissue culture infection dose, TCID50). Serum total superoxide dismutase (SOD) activity, malondialdehyde (MDA) level, tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP) and interleukin-1 beta (IL-1β) levels were measured at 5, 10, 15, 20 days post infection (dpi). The PCV2 virus load in the liver, spleen and lung, and the microscopic lesions in the liver, spleen and lung also were determined on 5, 10, 15, and 20 dpi. Dietary Se yeast supplementation decreased (Pμ0.05) the serum levels of TNF-α, but had no significant effect on the activity of SOD and the levels of MDA, CRP and IL-1β between experimental and control groups. Dietary Se yeast supplementation had little effect on the PCV2 virus load in the liver, spleen and lung. However, mice in the selenium yeast group showed a significant decrease in microscopic lesion scores in the lung and spleen compared with those in the control group (Pμ0.05). These data indicate Se yeast attenuated the PCV2 infection through altering the systemic inflammation and maintaining the normal organ morphology.

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Section: Discussionmentioning

confidence: 71%

Effect of Dietary Selenium Yeast Supplementation on Porcine Circovirus Type 2 (PCV2) Infections in Mice

et al. 2015

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“…In other cases, selenium deficiency impaired the innate immune response against Listera monocytogenes (Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection.) and increased mortality with a marked reduction in body weight and reduction of levels of TNF-and INF-in mice infected with the H1N1 influenza virus [48].…”

Section: Effects Of Selenium Supplementation On Trypanosomiasismentioning

confidence: 99%

Biological Implications of Selenium and its Role in Trypanosomiasis Treatment

Silva¹,

Silva²,

Thiemann³

2014

CMC

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Selenium (Se) is an essential trace element for several organisms and is present in proteins as selenocysteine (Sec or U), an amino acid that is chemically distinct from serine and cysteine by a single atom (Se instead of O or S, respectively). Sec is incorporated into selenoproteins at an in-frame UGA codon specified by an mRNA stem-loop structure called the selenocysteine incorporating sequence (SECIS) presented in selenoprotein mRNA and specific selenocysteine synthesis and incorporation machinery. Selenoproteins are presented in all domains but are not found in all organisms. Although several functions have been attributed to this class, the majority of the proteins are involved in oxidative stress defense. Here, we discuss the kinetoplastid selenocysteine pathway and how selenium supplementation is able to alter the infection course of trypanosomatids in detail. These organisms possess the canonical elements required for selenoprotein production such as phosphoseryl tRNA kinase (PSTK), selenocysteine synthase (SepSecS), selenophosphase synthase (SelD or SPS), and elongation factor EFSec (SelB), whereas other important factors presented in mammal cells, such as SECIS binding protein 2 (SBP) and SecP 43, are absent. The selenoproteome of trypanosomatids is small, as is the selenoproteome of others parasites, which is in contrast to the large number of selenoproteins found in bacteria, aquatic organisms and higher eukaryotes. Trypanosoma and Leishmania are sensitive to auranofin, a potent selenoprotein inhibitor; however, the probable drug mechanism is not related to selenoproteins in kinetoplastids. Selenium supplementation decreases the parasitemia of various Trypanosome infections and reduces important parameters associated with diseases such as anemia and parasite-induced organ damage. New experiments are necessary to determine how selenium acts, but evidence suggests that immune response modulation and increased host defense against oxidative stress contribute to control of the parasite infection.

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“…Interestingly, Se status had no affect on antibody production, suggesting that Se deficiency affects cell-mediated immunity to a greater extent than humoral immunity in this model. Se supplementation was found to be protective against H1N1 influenza infection (Yu et al, 2010). In this study, mice were fed deficient (0 ppm), adequate (0.2 ppm) and supplemented (0.3-0.5 ppm) levels of Se in their diets and infected with H1N1 at a dose that resulted in 41% survival in mice fed adequate Se diets.…”

Section: Selenium and Influenza Virusesmentioning

confidence: 99%