Protection From Cardiac Ischemia-Reperfusion Injury by Epigenetic Regulation of NADPH Oxidase

Au nanoflower film-based stretchable biosensors for in situ monitoring of superoxide anion release in cell mechanotransduction

“…Many researchers reported that cyclical and sustained stretches can trigger O 2 ˙ − release in both cultured endothelial and vascular cells, 52 which involves specific enzymes such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX family) catalyzing the following reaction as shown in Fig. 4D.…”

Injectable Nanocomposite Implants Reduce ROS Accumulation and Improve Heart Function after Infarction

“…Second, the potential of the composite hydrogel to absorb ROS in an ischemia‐reperfusion model was demonstrated. As the presence of ROS within the LV expands the injury, leading to extensive cell death, [ 6 , 39 , 40 , 41 , 42 ] inflammation [ 41 , 64 , 65 ] and, overall, to progressive damage, the ability to eliminate ROS may be extremely beneficial for treating MI and other heart diseases, as well as other injuries in different organs. Our results indicate that injection of the composite complex leads to cardioprotection within the LV, which, in turn, leads to the preservation of heart structure and function.…”

“…The damage from these factors is progressive, affecting the implanted tissue and jeopardizing the success of the treatment. [ 6 , 39 , 40 , 41 , 42 , 43 , 44 ]…”

“…The damage from these factors is progressive, affecting the implanted tissue and jeopardizing the success of the treatment. [6,[39][40][41][42][43][44] Here, we developed a new regenerative approach to promote the efficient transfer of the electrical signal between cells, reduce ROS levels and regenerate the diseased heart. Gold nanoparticles (AuNPs) were incorporated into an ECM-based hydrogel (composite hydrogel), which served as a scaffolding material for cardiac cells, and which together formed microcardiac implants with fast conduction velocity.…”