Protection contre l’allergie par l’environnement de la ferme : en 15 ans, qu’avons-nous appris de la cohorte européenne « PASTURE » ?

Vuitton, Dominique A.; Divaret‐Chauveau, Amandine; Dalphin, Marie‐Laure; Laplante, Jean‐Jacques; Mutius, Erika von; Dalphin, Jean‐Charles

doi:10.1016/j.banm.2019.05.020

Cited by 3 publications

(1 citation statement)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the past 20 years, traditional dairy farms have been studied in European cohorts to understand the specific factors of dairy farm environment involved in the protection of asthma and allergic diseases [5,8,9]. In addition to the exposure to a high endotoxin level, those studies have shown a protective effect of the consumption of raw cow's milk during pregnancy and in the first year of life [8] and also a protective effect of a diversity of early exposures [51], such as high food diversity [15] and exposure to different animal species [14]. Together with our results, these studies suggest that the protective effect of farm environment is not only due to the exposure to dairy farm's dust but also to several other factors.…”

Section: Plos Onementioning

confidence: 99%

Early exposure to farm dust in an allergic airway inflammation rabbit model: Does it affect bronchial and cough hyperresponsiveness?

et al. 2023

View full text Add to dashboard Cite

Introduction Over the past 50 years, the prevalence of allergic respiratory diseases has been increasing. The Hygiene hypothesis explains this progression by the decrease in the bio-diversity of early microbial exposure. This study aims to evaluate the effect of early-life farm exposure on airway hyperresponsiveness and cough hypersensitivity in an allergic airway inflammation rabbit model. Method A specific environment was applied to pregnant rabbits and their offspring until six weeks after birth. Rabbits were housed in a pathogen-free zone for the control group and a calf barn for the farm group. At the end of the specific environmental exposure, both groups were then housed in a conventional zone and then sensitized to ovalbumin. Ten days after sensitization, the rabbit pups received ovalbumin aerosols to provoke airway inflammation. Sensitization to ovalbumin was assessed by specific IgE assay. Cough sensitivity was assessed by mechanical stimulation of the trachea, and bronchial reactivity was assessed by methacholine challenge. The farm environment was characterized by endotoxin measurement. Results A total of 38 rabbit pups were included (18 in the farm group). Endotoxin levels in the farm environment varied from 30 to 1854 EU.m-3. There was no significant difference in specific IgE values to ovalbumin (p = 0.826) between the two groups. The mechanical threshold to elicit a cough did not differ between the two groups (p = 0.492). There was no difference in the number of cough (p = 0.270) or the intensity of ventilatory responses (p = 0.735). After adjusting for age and weight, there was no difference in respiratory resistance before and after methacholine challenge. Conclusion Early exposure to the calf barn did not affect cough sensitivity or bronchial reactivity in ovalbumin-sensitized rabbits. These results suggest that not all farm environments protect against asthma and atopy. Continuous exposure to several sources of microbial diversity is probably needed.

show abstract

Section: Plos Onementioning

confidence: 99%

Early exposure to farm dust in an allergic airway inflammation rabbit model: Does it affect bronchial and cough hyperresponsiveness?

et al. 2023

View full text Add to dashboard Cite

show abstract

Farm Environment, Raw Milk and Immunity: A “Field” Study of Tolerance Learning

Vuitton¹,

Laplante²,

Divaret‐Chauveau³

2022

Socioecosystems

View full text Add to dashboard Cite

Can raw milk cheese and pasteurised milk cheese coexist? Unthinkable or never really considered?

Marie

Mariani

Millet

et al. 2020

Rev Agric Food Environ Stud

View full text Add to dashboard Cite

This article examines the contentious issue of the coexistence of cheese made from raw milk and cheese made from pasteurised milk in areas of protected designation of origin (PDOs). The French PDO system is held to be the benchmark of the international system of geographical indications (GIs). Drawing on the multi-level perspective framework of socio-technical transitions, we conceptualise PDO cheeses as a "niche" nested within a dominant regime that promotes pasteurisation as the standard technology to control pathogens in milk. Careful examination of statistical data and the specifications for PDO cheeses shows that raw milk is experiencing an upturn in domestic production, which we relate to the reinforcement of the regulatory frameworks governing protection of GIs. We investigate more fully the steady increase in raw milk use by studying two contrasting cases of PDO cheeses (Saint-Nectaire and Ossau-Iraty), in which the confrontation between technologies is internalised. Analysis of local innovation pathways highlights a series of key decisions that strengthen the position of raw milk from the farm to the marketplace, namely grass-feeding, limiting herd productivity, technology-specific identification marks, and redistribution of decision-making power among stakeholders. Regulatory mechanisms that counterbalance the pressures of the regime by strategic management of the "terroir" niche are identified and discussed. We argue that shifting the focus from niche/regime interaction towards the internal dynamics of niches sheds light on the conditions of a coexistence of apparently antagonistic models of production in agri-food networks.

show abstract

Protection contre l’allergie par l’environnement de la ferme : en 15 ans, qu’avons-nous appris de la cohorte européenne « PASTURE » ?

Cited by 3 publications

References 80 publications

Early exposure to farm dust in an allergic airway inflammation rabbit model: Does it affect bronchial and cough hyperresponsiveness?

Early exposure to farm dust in an allergic airway inflammation rabbit model: Does it affect bronchial and cough hyperresponsiveness?

Farm Environment, Raw Milk and Immunity: A “Field” Study of Tolerance Learning

Can raw milk cheese and pasteurised milk cheese coexist? Unthinkable or never really considered?

Contact Info

Product

Resources

About