Protection by paracetamol against various gastric irritants in the rat

Kolfschoten, A. A. van; Zandberg, P.; Jager, L. P.; Noordwijk, J. van

doi:10.1016/0041-008x(83)90116-3

Cited by 23 publications

(19 citation statements)

References 8 publications

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“…Though there are no much reports regarding gastro protective effect of paracetamol when co administered with aceclofenac, Nimesulide and lornoxicam, there are several reports regarding such an activity of paracetamol when co administered with other agents like ethanol, inorganic acids and alkalies and indomethacin, aspirin. 4,15 In contrast to these earlier reports , the other studies have shown that paracetamol when coadministered failed to reduce the gastric toxicity of ethanol, aspirin, ibuprofen, phenylbutazone and glafenine in rats. 4,8,16,17 These could be attributed to higher doses used (3900mg and 2600mg) and shorter duration of treatment compared to that of present study.…”

Section: Discussioncontrasting

confidence: 51%

“…Gastric toxicity of aspirin, indomethacin and ibuprofen was deceased, when co administered with paracetamol in rats, but that of phenylbutazone and glafenine was not altered. 4,6 Paracetamol showed gastro protective activity with aspirin and ethanol in humans in one study, while in another study paracetamol showed no such protection with aspirin, and ibuprofen. [7][8][9] Yet another experimental study showed enhanced gastric toxicity of ibuprofen, when co administered with paracetamol, contrary to its protective role.…”

Section: Introductionmentioning

confidence: 99%

“…Studies indicate that paracetamol when administered concomitantly with various gastric irritants like absolute alcohol, inorganic acids and alkalies, reduces their gastric toxicity. 4 The minimal gastric toxicity of paracetamol and its protective role is said to be due to increase in prostaglandins production in gastric mucosa. 4,5 However, this gasto protective property of paracetamol appears to be not uniform with different NSAIDs and moreover there are controversial reports regarding gastro protective propertyof paracetamol with some NSAIDs.…”

Section: Introductionmentioning

confidence: 99%

“…4 The minimal gastric toxicity of paracetamol and its protective role is said to be due to increase in prostaglandins production in gastric mucosa. 4,5 However, this gasto protective property of paracetamol appears to be not uniform with different NSAIDs and moreover there are controversial reports regarding gastro protective propertyof paracetamol with some NSAIDs. Gastric toxicity of aspirin, indomethacin and ibuprofen was deceased, when co administered with paracetamol in rats, but that of phenylbutazone and glafenine was not altered.…”

Section: Introductionmentioning

confidence: 99%

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An experimental evaluation of gastro protective activity of paracetamol on ulcerogenicity of some NSAIDs in albino rats

Rajashekar

Shobha

2017

Int J Basic Clin Pharmacol

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Background: Fixed dose combinations (FDCs) of NSAIDs are commonly prescribed and extensively sold over the counter. An indiscriminate usage of them leads to toxicity, mainly involving gastrointestinal system. Paracetamol appears to have controversial reputation regarding its gastro protective action. In this background, the study was planned to evaluate gastro protective effect of paracetamol on the ulcerogenicity of some relatively new NSAIDs in their therapeutic and sub therapeutic doses. Methods: Gatric toxicity and gastric juice analysis-Pyloric ligation method was adopted for assessing the ulcer index of 3 NSAIDs namely aceclofenac, nimesulide and lornoxicam individually and in combination with paracetamol. Gastric juice collected was subjected for total juice volume, free acidity, combined acidity and total acid output. Results: Paracetamol produced non significant gastric damage similar to that of control. When co administered with therapeutic doses of aceclofenac, nimesulide and lornoxicam, there was significant decrease in their gastric toxicity in a uniform manner and the ulcerogenicity of these NSAIDs in sub therapeutic doses was not affected by paracetamol. This upholds the uniform gastro protective activity of paracetamol in this study and this could be explained by its anti acid secretory action on gastric juice. Conclusions: Paracetamol, itself has least gastric damaging property. When co administered with other NSAIDs, their toxicity is rather reduced than enhancing the mucosal damage by them. Thus FDCs of various NSAIDs available in market are partially justifiable.

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An experimental evaluation of gastro protective activity of paracetamol on ulcerogenicity of some NSAIDs in albino rats

Rajashekar

Shobha

2017

Int J Basic Clin Pharmacol

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“…Increased prostaglandin synthesis in the gastric mucosa by paracetamol could be responsible for its minimal gastric toxicity. 1,2 Since the gastric damage depends upon the suppression of prostaglandin E 2 biosynthesis which controls the mucosal blood flow and mucosal integrity.…”

Section: Introductionmentioning

confidence: 99%

An experimental evaluation of anti-inflammatory activities of some combined NSAID preparations in albino rats

Rajashekar

Shobha

2017

Int J Basic Clin Pharmacol

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Background: Non-steroidal anti-inflammatory drugs are among the most commonly used drugs across the globe and they are also available over the counter for minor symptoms of pain and inflammation. Their toxicity profile limits their continued usage and search is continuing for the better effective and safer agent.Methods: Interaction of paracetamol with diclofenac, ibuprofen and mefenamic acid were studied on carrageenan induced rat paw edema and cotton pellet induced granuloma models. Potentiation of these NSAIDs by paracetamol was also studied on same models.Results: Addition of paracetamol did not increase anti-inflammatory activity of diclofenac, ibuprofen and mefenamic acid in both acute and subacute models of inflammation. Paracetamol found to potentiate the ibuprofen action in anti-inflammatory model where as in subacute inflammatory model diclofenac action was potentited.Conclusions: Our study does not support the rationality of various fixed dose combination of NSAIDs with paracetamol available in market. Either NSAIDs to be used individually or their dose need to be decreased in fixed dose combination.

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Gastric cytoprotection: a critical appraisal of the concept, methodology, implications, mechanisms and future research prospects

1987

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Gastric cytoprotection is the property of certain substances, particularly prostaglandins, when used in non-antisecretory doses, to protect the gastric mucosa from becoming inflamed and necrotic on being exposed to noxious agents. An association between alterations in endogenous prostaglandins and gastric mucosal damage induced by a number of drugs has also been observed. The process of adaptive cytoprotection in which mild irritants protect the gastric mucosa against the damaging effects of various necrotizing agents has been shown to be prostaglandin mediated. However, the exact mechanisms underlying this cytoprotective activity have still not been elucidated although a number of hypotheses have been proposed. Recently, thromboxanes, leukotrienes and endogenous sulfhydryls have also been suggested to be involved in the pathogenesis of gastric mucosal damage induced by various necrotizing agents. This review attempts to provide an up-to-date appraisal of the concept, methodology, mechanisms and implications of this phenomenon and suggests that prostaglandins and endogenous sulfhydryls may play a significant role in the pathogenesis of gastric ulceration and may serve an important function in maintaining normal gastric mucosal integrity.

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Protection by paracetamol against various gastric irritants in the rat

Cited by 23 publications

References 8 publications

An experimental evaluation of gastro protective activity of paracetamol on ulcerogenicity of some NSAIDs in albino rats

An experimental evaluation of gastro protective activity of paracetamol on ulcerogenicity of some NSAIDs in albino rats

An experimental evaluation of anti-inflammatory activities of some combined NSAID preparations in albino rats

Gastric cytoprotection: a critical appraisal of the concept, methodology, implications, mechanisms and future research prospects

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